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Recent developments in synthetic biology, next-generation sequencing, and machine learning provide an unprecedented opportunity to rationally design new disease treatments based on measured responses to gene perturbations and drugs to…

Molecular Networks · Quantitative Biology 2024-03-12 Thomas P. Wytock , Adilson E. Motter

Sparse autoencoders (SAEs) operationalise the linear representation hypothesis: they reconstruct model activations as sparse linear combinations of interpretable dictionary atoms, on the implicit assumption that activation space is well…

Machine Learning · Computer Science 2026-05-12 Eslam Zaher , Maciej Trzaskowski , Quan Nguyen , Fred Roosta

We present a functional form (that we refer to as a Unified Neural Scaling Law (UNSL)) that accurately models and extrapolates the scaling behaviors of deep neural networks as multiple dimensions all vary simultaneously (i.e. how the…

Machine Learning · Computer Science 2026-05-27 Ethan Caballero , Priyank Jaini , David Krueger , Irina Rish

Scaling laws describe the relationship between the size of language models and their capabilities. Unlike prior studies that evaluate a model's capability via loss or benchmarks, we estimate the number of knowledge bits a model stores. We…

Computation and Language · Computer Science 2024-04-09 Zeyuan Allen-Zhu , Yuanzhi Li

Recent works have highlighted optimization difficulties faced by gradient descent in training the first and last layers of transformer-based language models, which are overcome by optimizers such as Adam. These works suggest that the…

Machine Learning · Computer Science 2025-05-27 Frederik Kunstner , Francis Bach

We study the asymptotic behavior of multiscale stochastic spatial gene networks. Multiscaling takes into account the difference of abundance between molecules , and captures the dynamic of rare species at a mesoscopic level. We introduce an…

Analysis of PDEs · Mathematics 2017-11-17 Arnaud Debussche , Mac Jugal Nguepedja Nankep

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

Genomics · Quantitative Biology 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

This paper explores the intricate behavior of deep neural networks (DNNs) through the lens of neuron activation dynamics. We propose a probabilistic framework that can analyze models' neuron activation patterns as a stochastic process,…

Artificial Intelligence · Computer Science 2024-12-25 Yizhou Zhang , Yang Sui

Motivation: Gene regulatory interactions are of fundamental importance to various biological functions and processes. However, only a few previous computational studies have claimed success in revealing genome-wide regulatory landscapes…

Molecular Networks · Quantitative Biology 2017-02-09 Shupeng Gui , Rui Chen , Liang Wu , Ji Liu , Hongyu Miao

Scaling laws aim to accurately predict model performance across different scales. Existing scaling-law studies almost exclusively rely on cross-entropy as the evaluation metric. However, cross-entropy provides only a partial view of…

Machine Learning · Computer Science 2025-10-24 Baoqing Yue , Jinyuan Zhou , Zixi Wei , Jingtao Zhan , Qingyao Ai , Yiqun Liu

We present a limited empirical study of scaling laws for transfer learning in transformer models. More specifically, we examine a scaling law that incorporates a "transfer gap" term, indicating the effectiveness of pre-training on one…

Machine Learning · Computer Science 2024-09-02 Matthew Barnett

Code large language models (Code LLMs) are powerful but costly to train, with scaling laws predicting performance from model size, data, and compute. However, different programming languages (PLs) have varying impacts during pre-training…

Computation and Language · Computer Science 2025-12-16 Jian Yang , Shawn Guo , Lin Jing , Wei Zhang , Aishan Liu , Chuan Hao , Zhoujun Li , Wayne Xin Zhao , Xianglong Liu , Weifeng Lv , Bryan Dai

The scaling exponent $\alpha$ in neural scaling laws $L(N) \propto N^{-\alpha}$ is commonly treated as a fixed constant set by architecture and data. We present evidence that $\alpha$ depends systematically on the optimizer. In controlled…

Machine Learning · Computer Science 2026-05-29 Vansh Ramani , Shourya Vir Jain

This paper investigates the information encoded in the embeddings of large language models (LLMs). We conduct simulations to analyze the representation entropy and discover a power law relationship with model sizes. Building upon this…

Machine Learning · Computer Science 2024-02-07 Zhiquan Tan , Chenghai Li , Weiran Huang

Experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We show that a theory based on a weakly…

Biological Physics · Physics 2018-01-03 E. Werner , G. K. Cheong , D. Gupta , K. D. Dorfman , B. Mehlig

While scaling laws govern aggregate large language model performance, no scaling law has linked factual recall to both model size and training-data composition. We evaluated 38 models on over 8,900 scholarly references evaluated by an…

Computation and Language · Computer Science 2026-05-19 Matthew L. Smith , Jonathan P. Shock , Samuel T. Segun , Iyiola E. Olatunji , Tegawendé F. Bissyandé

Scaling laws describe how learning performance improves with data, compute, or training time, and have become a central theme in modern deep learning. We study this phenomenon in a canonical nonlinear model: phase retrieval with anisotropic…

Machine Learning · Statistics 2025-11-25 Guillaume Braun , Bruno Loureiro , Ha Quang Minh , Masaaki Imaizumi

Empirical scaling laws prescribe how to allocate parameters, data, and compute, while maximal-update parameterization ($\mu$P) enables learning-rate transfer across widths by equalizing early-time update magnitudes. However, in modern…

Machine Learning · Computer Science 2025-10-20 Zhiyuan Fan , Yifeng Liu , Qingyue Zhao , Angela Yuan , Quanquan Gu

Despite recent advancements of large language models (LLMs), optimally predicting the model size for LLM pretraining or allocating optimal resources still remains a challenge. Several efforts have addressed the challenge by proposing…

Machine Learning · Computer Science 2026-02-11 Md Arafat Hossain , Xingfu Wu , Valerie Taylor , Ali Jannesari

The quality of Large Language Model (LLM) pretraining depends on multiple factors, including the compute budget and the choice of optimization algorithm. Empirical scaling laws are widely used to predict loss as model size and training data…

Machine Learning · Computer Science 2026-02-25 Alexandra Volkova , Mher Safaryan , Christoph H. Lampert , Dan Alistarh
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