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The vast majority of semantic segmentation approaches rely on pixel-level annotations that are tedious and time consuming to obtain and suffer from significant inter and intra-expert variability. To address these issues, recent approaches…

Pathology computing has dramatically improved pathologists' workflow and diagnostic decision-making processes. Although computer-aided diagnostic systems have shown considerable value in whole slide image (WSI) analysis, the problem of…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Yonghuang Wu , Xuan Xie , Xinyuan Niu , Chengqian Zhao , Jinhua Yu

We address the problem of automated nuclear segmentation, classification, and quantification from Haematoxylin and Eosin stained histology images, which is of great relevance for several downstream computational pathology applications. In…

Computer Vision and Pattern Recognition · Computer Science 2022-04-19 Lihao Liu , Chenyang Hong , Angelica I. Aviles-Rivero , Carola-Bibiane Schönlieb

Weakly supervised instance segmentation using only bounding box annotations has recently attracted much research attention. Most of the current efforts leverage low-level image features as extra supervision without explicitly exploiting the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Ruihuang Li , Chenhang He , Yabin Zhang , Shuai Li , Liyi Chen , Lei Zhang

In digital pathology, Whole Slide Image (WSI) analysis is usually formulated as a Multiple Instance Learning (MIL) problem. Although transformer-based architectures have been used for WSI classification, these methods require modifications…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Juan I. Pisula , Katarzyna Bozek

Foundation models are increasingly applied to computational pathology, yet their behavior under cross-cancer and cross-species transfer remains unspecified. This study investigated how fine-tuning CPath-CLIP affects cancer detection under…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Ekansh Arora

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…

In this study, we propose a method that distils representations of word meaning in context from a pre-trained masked language model in both monolingual and crosslingual settings. Word representations are the basis for context-aware lexical…

Computation and Language · Computer Science 2024-09-16 Yuki Arase , Tomoyuki Kajiwara

Recent breakthroughs in object detection and image classification using Convolutional Neural Networks (CNNs) are revolutionizing the state of the art in medical imaging, and microscopy in particular presents abundant opportunities for…

Image and Video Processing · Electrical Eng. & Systems 2020-07-07 Rui Aguiar , Jon Braatz

Deep learning has become the mainstream methodological choice for analyzing and interpreting whole-slide digital pathology images (WSIs). It is commonly assumed that tumor regions carry most predictive information. In this paper, we…

Quantitative Methods · Quantitative Biology 2022-04-26 Zihan Chen , Xingyu Li , Miaomiao Yang , Hong Zhang , Xu Steven Xu

Medical image segmentation is a crucial task in medical image analysis, but it can be very challenging especially when there are less labeled data but with large unlabeled data. Contrastive learning has proven to be effective for medical…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Shihuan He , Zhihui Lai , Ruxin Wang , Heng Kong

Encoding whole slide images (WSI) as graphs is well motivated since it makes it possible for the gigapixel resolution WSI to be represented in its entirety for the purpose of graph learning. To this end, WSIs can be broken into smaller…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Milan Aryal , Nasim Yahyasoltani

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Multiple instance learning is an ideal mode of analysis for histopathology data, where vast whole slide images are typically annotated with a single global label. In such cases, a whole slide image is modelled as a collection of tissue…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Leo Fillioux , Joseph Boyd , Maria Vakalopoulou , Paul-Henry Cournède , Stergios Christodoulidis

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

In histopathology, tissue samples are often larger than a standard microscope slide, making stitching of multiple fragments necessary to process entire structures such as tumors. Automated stitching is a prerequisite for scaling analysis,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Stefan Brandstätter , Maximilian Köller , Philipp Seeböck , Alissa Blessing , Felicitas Oberndorfer , Svitlana Pochepnia , Helmut Prosch , Georg Langs

Unsupervised disentangled representation learning is a long-standing problem in computer vision. This work proposes a novel framework for performing image clustering from deep embeddings by combining instance-level contrastive learning with…

Machine Learning · Computer Science 2021-10-05 Ramakrishnan Sundareswaran , Jansel Herrera-Gerena , John Just , Ali Jannesari

Breast cancer is one of the factors that cause the increase of mortality of women. The most widely used method for diagnosing this geological disease i.e. breast cancer is the ultrasound scan. Several key features such as the smoothness and…

Artificial Intelligence · Computer Science 2021-08-10 Mohamed Mejri , Aymen Mejri , Oumayma Mejri , Chiraz Fekih

Sparse representation classification achieves good results by addressing recognition problem with sufficient training samples per subject. However, SRC performs not very well for small sample data. In this paper, an inverse-projection group…

Computer Vision and Pattern Recognition · Computer Science 2018-03-14 Xiaohui Yang , Xiaoying Jiang , Wenming Wu , Juan Zhang , Dan Long , Funa Zhou , Yiming Xu