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Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Drug synergy prediction (DSP) aims to identify efficacious drug combinations under various cellular contexts with different targets. However, the continual emergence of novel compounds results in variations in molecular scaffolds and sizes,…

Machine Learning · Computer Science 2026-05-29 Xin Wang , Linxin Xiao , Yang Yao , Wenwu Zhu

Knowledge Graph-based Retrieval-Augmented Generation (KG-RAG) significantly enhances the reasoning capabilities of LargeLanguage Models by leveraging structured knowledge. However, existing KG-RAG frameworks typically operate as open-loop…

Information Retrieval · Computer Science 2025-08-14 Xujie Yuan , Shimin Di , Jielong Tang , Libin Zheng , Jian Yin

Constructing domain-specific knowledge graphs from unstructured text remains challenging due to heterogeneous entity mentions, long-tail relation distributions, and the absence of standardized schemas. We present LEC-KG, a bidirectional…

Computation and Language · Computer Science 2026-03-02 Yikai Zeng , Yingchao Piao , Changhua Pei , Jianhui Li

Personalizing language models by effectively incorporating user interaction history remains a central challenge in the development of adaptive AI systems. While large language models (LLMs), combined with Retrieval-Augmented Generation…

Computation and Language · Computer Science 2026-04-14 Mikhail Menschikov , Dmitry Evseev , Victoria Dochkina , Ruslan Kostoev , Ilia Perepechkin , Petr Anokhin , Nikita Semenov , Evgeny Burnaev

Despite the remarkable progress of Large Language Models (LLMs), their performance in question answering (QA) remains limited by the lack of domain-specific and up-to-date knowledge. Retrieval-Augmented Generation (RAG) addresses this…

Information Retrieval · Computer Science 2025-09-17 Yaodong Su , Yixiang Fang , Yingli Zhou , Quanqing Xu , Chuanhui Yang

Biomedical knowledge graphs (KGs) encode vast, heterogeneous information spanning literature, genes, pathways, drugs, diseases, and clinical trials, but leveraging them collectively for scientific discovery remains difficult. Their…

Information Retrieval · Computer Science 2026-01-21 Zifeng Wang , Zheng Chen , Ziwei Yang , Xuan Wang , Qiao Jin , Yifan Peng , Zhiyong Lu , Jimeng Sun

Knowledge graphs, a powerful tool for structuring information through relational triplets, have recently become the new front-runner in enhancing question-answering systems. While traditional Retrieval Augmented Generation (RAG) approaches…

Artificial Intelligence · Computer Science 2025-09-12 Vaibhav Chaudhary , Neha Soni , Narotam Singh , Amita Kapoor

Multi-step agentic retrieval systems based on large language models (LLMs) have demonstrated remarkable performance in complex information search tasks. However, these systems still face significant challenges in practical applications,…

Machine Learning · Computer Science 2025-10-16 Chuzhan Hao , Wenfeng Feng , Yuewei Zhang , Hao Wang

Retrieval-Augmented Generation (RAG) is one of the leading and most widely used techniques for enhancing LLM retrieval capabilities, but it still faces significant limitations in commercial use cases. RAG primarily relies on the query-chunk…

Knowledge graphs (KGs) offer a rich representation for relational knowledge, but their irregular structure makes retrieval challenging: ego-graph expansion grows rapidly, and dense embedding methods struggle with multi-hop compositional…

Machine Learning · Computer Science 2026-05-25 Hamed Shirzad , Frederik Wenkel , Dominique Beaini , Danica J. Sutherland , Emmanuel Noutahi

In the current development of large language models (LLMs), it is important to ensure the accuracy and reliability of the underlying data sources. LLMs are critical for various applications, but they often suffer from hallucinations and…

Artificial Intelligence · Computer Science 2025-01-14 Jiayang Wu , Wensheng Gan , Jiahao Zhang , Philip S. Yu

Large language models (LLMs) struggle with the factual error during inference due to the lack of sufficient training data and the most updated knowledge, leading to the hallucination problem. Retrieval-Augmented Generation (RAG) has gained…

Information Retrieval · Computer Science 2026-01-22 Zulun Zhu , Tiancheng Huang , Kai Wang , Junda Ye , Xinghe Chen , Siqiang Luo

Retrieval-augmented generation (RAG) is a powerful paradigm for improving large language models (LLMs) on knowledge-intensive question answering. Graph-based RAG (GraphRAG) leverages entity-relation graphs to support multi-hop reasoning,…

Artificial Intelligence · Computer Science 2025-10-01 Kai Guo , Xinnan Dai , Shenglai Zeng , Harry Shomer , Haoyu Han , Yu Wang , Jiliang Tang

Large language models (LLMs) have demonstrated impressive reasoning abilities yet remain unreliable on knowledge-intensive, multi-hop questions -- they miss long-tail facts, hallucinate when uncertain, and their internal knowledge lags…

Computation and Language · Computer Science 2025-10-13 Jia Ao Sun , Hao Yu , Fabrizio Gotti , Fengran Mo , Yihong Wu , Yuchen Hui , Jian-Yun Nie

Advancements in the capabilities of Large Language Models (LLMs) have created a promising foundation for developing autonomous agents. With the right tools, these agents could learn to solve tasks in new environments by accumulating and…

Artificial Intelligence · Computer Science 2025-05-16 Petr Anokhin , Nikita Semenov , Artyom Sorokin , Dmitry Evseev , Andrey Kravchenko , Mikhail Burtsev , Evgeny Burnaev

Large language models (LLMs) are transforming the way information is retrieved with vast amounts of knowledge being summarized and presented via natural language conversations. Yet, LLMs are prone to highlight the most frequently seen…

Computation and Language · Computer Science 2024-02-20 Julien Delile , Srayanta Mukherjee , Anton Van Pamel , Leonid Zhukov

Retrieval-Augmented Generation (RAG) enhances LLMs by grounding generation in query-relevant external evidence. Beyond unstructured text corpora, Graph RAG integrates knowledge graphs into the retrieval pipeline, enabling LLMs to access…

Cryptography and Security · Computer Science 2026-05-28 Jinze Gu , Qinghua Mao , Xi Lin , Jun Wu

Large language models suffer from knowledge staleness and lack of interpretability due to implicit knowledge storage across entangled network parameters, preventing targeted updates and reasoning transparency. We propose ExplicitLM, a novel…

Artificial Intelligence · Computer Science 2025-11-04 Chengzhang Yu , Zening Lu , Chenyang Zheng , Chiyue Wang , Yiming Zhang , Zhanpeng Jin

Despite the advances in large language models (LLMs), how they use their knowledge for reasoning is not yet well understood. In this study, we propose a method that deconstructs complex real-world questions into a graph, representing each…

Computation and Language · Computer Science 2024-10-07 Miyoung Ko , Sue Hyun Park , Joonsuk Park , Minjoon Seo