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Related papers: Order Matters in Retrosynthesis: Structure-aware G…

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Single-step retrosynthesis aims to predict a set of reactions that lead to the creation of a target molecule, which is a crucial task in molecular discovery. Although a target molecule can often be synthesized with multiple different…

Machine Learning · Computer Science 2025-04-15 Piotr Gaiński , Michał Koziarski , Krzysztof Maziarz , Marwin Segler , Jacek Tabor , Marek Śmieja

Crystal structure prediction is a long-standing challenge in materials science, with most data-driven methods developed for inorganic systems. This leaves an important gap for organic crystals, which are central to pharmaceuticals,…

Materials Science · Physics 2026-02-25 Mohammadmahdi Vahediahmar , Matthew A. McDonald , Feng Liu

Reference-based object composition involves integrating foreground reference image with background scene to produce harmonious fused image. This task becomes particularly challenging in cross-domain scenarios, where models must balance…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Raghu Vamsi Chittersu , Yuvraj Singh Rathore , Pranav Adlinge , Kunal Swami

A range of generative machine learning models for the design of novel molecules and materials have been proposed in recent years. Models that can generate three-dimensional structures are particularly suitable for quantum chemistry…

A method for reconstructing the direction of a fast neutron source using a segmented organic scintillator-based detector and deep learning model is proposed and analyzed. The model is based on recurrent neural network, which can be trained…

Instrumentation and Detectors · Physics 2023-01-27 Jun Woo Bae , Tingshiuan C. Wu , Igor Jovanovic

Self-organization is ubiquitous in nature and mind. However, machine learning and theories of cognition still barely touch the subject. The hurdle is that general patterns are difficult to define in terms of dynamical equations and…

Artificial Intelligence · Computer Science 2023-02-07 Danilo Vasconcellos Vargas , Tham Yik Foong , Heng Zhang

Molecular building blocks interacting at the nanoscale organize spontaneously into stable mono- layers that display intriguing long-range ordering motifs on the surface of atomic substrates. The patterning process, if appropriately…

Mesoscale and Nanoscale Physics · Physics 2011-02-18 Marta Balbás Gambra , Carsten Rohr , Kathrin Gruber , Bianca Hermann , Thomas Franosch

Switching between different levels of resolution is essential for multiscale modeling, but restoring details at higher resolution remains challenging. In our previous study we have introduced deepBackmap: a deep neural-network-based…

Chemical Physics · Physics 2024-06-12 Marc Stieffenhofer , Tristan Bereau , Michael Wand

The objective of this paper is to design novel multi-layer neural network architectures for multiscale simulations of flows taking into account the observed data and physical modeling concepts. Our approaches use deep learning concepts…

Numerical Analysis · Mathematics 2018-06-14 Yating Wang , Siu Wun Cheung , Eric T. Chung , Yalchin Efendiev , Min Wang

While the ``deep reasoning'' paradigm has spurred significant advances in verifiable domains like mathematics, its application to open-ended, creative generation remains a critical challenge. The two dominant methods for instilling…

Artificial Intelligence · Computer Science 2025-09-09 Haozhe Wang , Haoran Que , Qixin Xu , Minghao Liu , Wangchunshu Zhou , Jiazhan Feng , Wanjun Zhong , Wei Ye , Tong Yang , Wenhao Huang , Ge Zhang , Fangzhen Lin

The disconnect between AI-generated molecules with desirable properties and their synthetic feasibility remains a critical bottleneck in computational discovery of drugs and materials. While generative AI has accelerated the proposal of…

Chemical Physics · Physics 2025-11-25 Shuan Chen , Gunwook Nam , Alan Aspuru-Guzik , Yousung Jung

We present an adaptive reduced-order model for the efficient time-resolved simulation of fluid-structure interaction problems with complex and non-linear deformations. The model is based on repeated linearizations of the structural balance…

Fluid Dynamics · Physics 2020-04-13 Ali Thari , Vito Pasquariello , Niels Aage , Stefan Hickel

Transition states (TSs) govern the rates and outcomes of chemical reactions, making their accurate prediction a central challenge in computational chemistry. Although recent machine-learning models achieve near chemical accuracy in the…

Machine learning is becoming a preferred method for the virtual screening of organic materials due to its cost-effectiveness over traditional computationally demanding techniques. However, the scarcity of labeled data for organic materials…

Chemical Physics · Physics 2024-03-06 Chengwei Zhang , Yushuang Zhai , Ziyang Gong , Hongliang Duan , Yuan-Bin She , Yun-Fang Yang , An Su

Reaction prediction is a fundamental problem in computational chemistry. Existing approaches typically generate a chemical reaction by sampling tokens or graph edits sequentially, conditioning on previously generated outputs. These…

Chemical Physics · Physics 2021-02-08 Hangrui Bi , Hengyi Wang , Chence Shi , Jian Tang

Retrosynthesis, which aims to find a route to synthesize a target molecule from commercially available starting materials, is a critical task in drug discovery and materials design. Recently, the combination of ML-based single-step reaction…

Artificial Intelligence · Computer Science 2024-03-05 Guoqing Liu , Di Xue , Shufang Xie , Yingce Xia , Austin Tripp , Krzysztof Maziarz , Marwin Segler , Tao Qin , Zongzhang Zhang , Tie-Yan Liu

Molecular structure generation is a fundamental problem that involves determining the 3D positions of molecules' constituents. It has crucial biological applications, such as molecular docking, protein folding, and molecular design. Recent…

Machine Learning · Computer Science 2025-08-27 Wenyin Zhou , Christopher Iliffe Sprague , Vsevolod Viliuga , Matteo Tadiello , Arne Elofsson , Hossein Azizpour

Manipulation in cluttered environments is challenging due to spatial dependencies among objects, where an improper manipulation order can cause collisions or blocked access. Existing approaches often overlook these spatial relationships,…

Robotics · Computer Science 2026-01-01 Yuxiang Yan , Zhiyuan Zhou , Xin Gao , Guanghao Li , Shenglin Li , Jiaqi Chen , Qunyan Pu , Jian Pu

Transformers can generate predictions in two approaches: 1. auto-regressively by conditioning each sequence element on the previous ones, or 2. directly produce an output sequences in parallel. While research has mostly explored upon this…

Computer Vision and Pattern Recognition · Computer Science 2021-08-18 Andrea Alfieri , Yancong Lin , Jan C. van Gemert

Sequence modeling has demonstrated state-of-the-art performance on natural language and document understanding tasks. However, it is challenging to correctly serialize tokens in form-like documents in practice due to their variety of layout…

Computation and Language · Computer Science 2022-03-25 Chen-Yu Lee , Chun-Liang Li , Timothy Dozat , Vincent Perot , Guolong Su , Nan Hua , Joshua Ainslie , Renshen Wang , Yasuhisa Fujii , Tomas Pfister