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Diffusion models have recently enabled state-of-the-art reconstruction of positron emission tomography (PET) images while requiring only image training data. However, domain shift remains a key concern for clinical adoption: priors trained…

Medical Physics · Physics 2025-10-16 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Scaling by training on large datasets has been shown to enhance the quality and fidelity of image generation and manipulation with diffusion models; however, such large datasets are not always accessible in medical imaging due to cost and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-14 Yousef Yeganeh , Azade Farshad , Ioannis Charisiadis , Marta Hasny , Martin Hartenberger , Björn Ommer , Nassir Navab , Ehsan Adeli

Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions…

Image and Video Processing · Electrical Eng. & Systems 2024-12-24 Abdullah al Nomaan Nafi , Md. Alamgir Hossain , Rakib Hossain Rifat , Md Mahabub Uz Zaman , Md Manjurul Ahsan , Shivakumar Raman

We introduce Diffusion Active Learning, a novel approach that combines generative diffusion modeling with data-driven sequential experimental design to adaptively acquire data for inverse problems. Although broadly applicable, we focus on…

Machine Learning · Computer Science 2025-04-07 Luis Barba , Johannes Kirschner , Tomas Aidukas , Manuel Guizar-Sicairos , Benjamín Béjar

Magnetic resonance (MR) imaging, including cardiac MR, is prone to domain shift due to variations in imaging devices and acquisition protocols. This challenge limits the deployment of trained AI models in real-world scenarios, where…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xin Ci Wong , Duygu Sarikaya , Kieran Zucker , Marc De Kamps , Nishant Ravikumar

Diffusion models demonstrate state-of-the-art performance on image generation, and are gaining traction for sparse medical image reconstruction tasks. However, compared to classical reconstruction algorithms relying on simple analytical…

Diffusion models have been demonstrated as powerful deep learning tools for image generation in CT reconstruction and restoration. Recently, diffusion posterior sampling, where a score-based diffusion prior is combined with a likelihood…

Medical Physics · Physics 2024-09-02 Shudong Li , Xiao Jiang , Matthew Tivnan , Grace J. Gang , Yuan Shen , J. Webster Stayman

Generative foundation models like Stable Diffusion comprise a diverse spectrum of knowledge in computer vision with the potential for transfer learning, e.g., via generating data to train student models for downstream tasks. This could…

Computer Vision and Pattern Recognition · Computer Science 2024-05-07 Leonhard Hennicke , Christian Medeiros Adriano , Holger Giese , Jan Mathias Koehler , Lukas Schott

Diffusion models have achieved excellent success in solving inverse problems due to their ability to learn strong image priors, but existing approaches require a large training dataset of images that should come from the same distribution…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Jason Hu , Bowen Song , Jeffrey A. Fessler , Liyue Shen

Diffusion models have recently emerged as powerful generative models in medical imaging. However, it remains a major challenge to combine these data-driven models with domain knowledge to guide brain imaging problems. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Ana Lawry Aguila , Dina Zemlyanker , You Cheng , Sudeshna Das , Daniel C. Alexander , Oula Puonti , Annabel Sorby-Adams , W. Taylor Kimberly , Juan Eugenio Iglesias

The reconstruction of X-rays CT images from sparse or limited-angle geometries is a highly challenging task. The lack of data typically results in artifacts in the reconstructed image and may even lead to object distortions. For this…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Davide Evangelista , Pasquale Cascarano , Elena Loli Piccolomini

Diffusion models have emerged as powerful priors for solving inverse problems in computed tomography (CT). In certain applications, such as neutron CT, it can be expensive to collect large amounts of measurements even for a single scan,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Timofey Efimov , Singanallur Venkatakrishnan , Maliha Hossain , Haley Duba-Sullivan , Amirkoushyar Ziabari

Cross-modal image translation remains brittle and inefficient. Standard diffusion approaches often rely on a single, global linear transfer between domains. We find that this shortcut forces the sampler to traverse off-manifold, high-cost…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Zihao Wang , Yuzhou Chen , Shaogang Ren

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

The dose of X-ray radiation and the scanning time are crucial factors in computed tomography (CT) for clinical applications. In this work, we introduce a multi-source static CT imaging system designed to rapidly acquire sparse view and…

Medical Physics · Physics 2025-01-03 Ziju Shen , Haimiao Zhang , Bin Dong , Jun Qiu , Yunxiang Li , Zhili Cui

Blind face restoration methods have shown remarkable performance, particularly when trained on large-scale synthetic datasets with supervised learning. These datasets are often generated by simulating low-quality face images with a…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Tianshu Kuai , Sina Honari , Igor Gilitschenski , Alex Levinshtein

Medical imaging has revolutionized disease diagnosis, yet the potential is hampered by limited access to diverse and privacy-conscious datasets. Open-source medical datasets, while valuable, suffer from data quality and clinical information…

Image and Video Processing · Electrical Eng. & Systems 2023-12-13 Gauri Bhardwaj , Yuvaraj Govindarajulu , Sundaraparipurnan Narayanan , Pavan Kulkarni , Manojkumar Parmar

Sparse-view sampling in dual-energy computed tomography (DECT) significantly reduces radiation dose and increases imaging speed, yet is highly prone to artifacts. Although diffusion models have demonstrated potential in effectively handling…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Zini Chen , Yao Xiao , Junyan Zhang , Shaoyu Wang , Liu Shi , Qiegen Liu

While originally designed for image generation, diffusion models have recently shown to provide excellent pretrained feature representations for semantic segmentation. Intrigued by this result, we set out to explore how well…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Rui Gong , Martin Danelljan , Han Sun , Julio Delgado Mangas , Luc Van Gool

Using recent advances in generative artificial intelligence (AI) brought by diffusion models, this paper introduces a new synergistic method for spectral computed tomography (CT) reconstruction. Diffusion models define a neural network to…

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