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We propose a data-efficient, physics-aware generative framework in function space for inverse PDE problems. Existing plug-and-play diffusion posterior samplers represent physics implicitly through joint coefficient-solution modeling,…

Machine Learning · Computer Science 2026-03-03 Thomas Y. L. Lin , Jiachen Yao , Lufang Chiang , Julius Berner , Anima Anandkumar

We propose a general framework for conditional sampling in PDE-based inverse problems, targeting the recovery of whole solutions from extremely sparse or noisy measurements. This is accomplished by a function-space diffusion model and…

Machine Learning · Computer Science 2026-02-06 Jiachen Yao , Abbas Mammadov , Julius Berner , Gavin Kerrigan , Jong Chul Ye , Kamyar Azizzadenesheli , Anima Anandkumar

Inverse problems, where the goal is to recover an unknown signal from noisy or incomplete measurements, are central to applications in medical imaging, remote sensing, and computational biology. Diffusion models have recently emerged as…

Machine Learning · Computer Science 2026-01-15 Shayan Mohajer Hamidi , En-Hui Yang , Ben Liang

Diffusion models have emerged as a powerful foundation model for visual generations. With an appropriate sampling process, it can effectively serve as a generative prior for solving general inverse problems. Current posterior sampling-based…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Shijie Zhou , Huaisheng Zhu , Rohan Sharma , Jiayi Chen , Ruiyi Zhang , Kaiyi Ji , Changyou Chen

Diffusion models have shown strong performances in solving inverse problems through posterior sampling while they suffer from errors during earlier steps. To mitigate this issue, several Decoupled Posterior Sampling methods have been…

Machine Learning · Computer Science 2025-04-15 Zhi Qi , Shihong Yuan , Yulin Yuan , Linling Kuang , Yoshiyuki Kabashima , Xiangming Meng

This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…

Many spectral CT applications require accurate material decomposition. Existing material decomposition algorithms are often susceptible to significant noise magnification or, in the case of one-step model-based approaches, hampered by slow…

Medical Physics · Physics 2025-07-22 Xiao Jiang , Grace J. Gang , J. Webster Stayman

We provide a framework for solving inverse problems with diffusion models learned from linearly corrupted data. Firstly, we extend the Ambient Diffusion framework to enable training directly from measurements corrupted in the Fourier…

Computer Vision and Pattern Recognition · Computer Science 2025-04-23 Asad Aali , Giannis Daras , Brett Levac , Sidharth Kumar , Alexandros G. Dimakis , Jonathan I. Tamir

In this work, we introduce a new deep learning approach based on diffusion posterior sampling (DPS) to perform material decomposition from spectral CT measurements. This approach combines sophisticated prior knowledge from unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2024-02-07 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Flow matching is a recent state-of-the-art framework for generative modeling based on ordinary differential equations (ODEs). While closely related to diffusion models, it provides a more general perspective on generative modeling. Although…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Jeongsol Kim , Bryan Sangwoo Kim , Jong Chul Ye

Diffusion Posterior Sampling (DPS) can be used in Computed Tomography (CT) reconstruction by leveraging diffusion-based generative models for unconditional image synthesis while matching the observations (data) of a CT scan. Of particular…

Inverse problems exist in many disciplines of science and engineering. In computer vision, for example, tasks such as inpainting, deblurring, and super resolution can be effectively modeled as inverse problems. Recently, denoising diffusion…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Shayan Mohajer Hamidi , En-Hui Yang

Diffusion Posterior Sampling(DPS) methodology is a novel framework that permits nonlinear CT reconstruction by integrating a diffusion prior and an analytic physical system model, allowing for one-time training for different applications.…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Xiao Jiang , Shudong Li , Peiqing Teng , Grace Gang , J. Webster Stayman

With the rapid development of diffusion models and flow-based generative models, there has been a surge of interests in solving noisy linear inverse problems, e.g., super-resolution, deblurring, denoising, colorization, etc, with generative…

Machine Learning · Computer Science 2024-10-22 Xiangming Meng , Yoshiyuki Kabashima

Accurately capturing the full-range response of structures is crucial in structural health monitoring (SHM) for ensuring safety and operational integrity. However, limited sensor deployment due to cost, accessibility, or scale often hinders…

Computational Engineering, Finance, and Science · Computer Science 2025-09-25 Wingho Feng , Quanwang Li , Chen Wang , Jian-sheng Fan

Deep generative models have emerged as state-of-the-art for solving inverse problems, but applying them to inverse problems for PDEs, like electrical impedance tomography (EIT) remains challenging. Because physical domains are naturally…

Image and Video Processing · Electrical Eng. & Systems 2026-05-20 Giovanni S. Alberti , Damiana Lazzaro , Serena Morigi , Matteo Santacesaria , Shibo Wang

Diffusion models have been used in cosmological applications as a generative model for fast simulations and to reconstruct underlying cosmological fields or astrophysical images from noisy data. These two tasks are often treated as…

Cosmology and Nongalactic Astrophysics · Physics 2025-02-07 Supranta S. Boruah , Michael Jacob , Bhuvnesh Jain

Diffusion-based posterior samplers use pretrained diffusion priors to sample from measurement- or reward-conditioned posteriors, and are widely used for inverse problems. Yet their theoretical behavior remains poorly understood: even with…

Machine Learning · Computer Science 2026-05-08 Matias G. Delgadino , Sebastien Motsch , Advait Parulekar , William Porteous , Sanjay Shakkottai

Inverse problems are fundamental to science and engineering, where the goal is to infer an underlying signal or state from incomplete or noisy measurements. Recent approaches employ diffusion models as powerful implicit priors for such…

Machine Learning · Computer Science 2025-11-27 Bilal Ahmed , Joseph G. Makin

Deconvolution of astronomical images is a key aspect of recovering the intrinsic properties of celestial objects, especially when considering ground-based observations. This paper explores the use of diffusion models (DMs) and the Diffusion…

Instrumentation and Methods for Astrophysics · Physics 2025-01-22 Alessio Spagnoletti , Alexandre Boucaud , Marc Huertas-Company , Wassim Kabalan , Biswajit Biswas
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