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Medical data poses a daunting challenge for AI algorithms: it exists in many different modalities, experiences frequent distribution shifts, and suffers from a scarcity of examples and labels. Recent advances, including transformers and…

Fine-tuning of Large Language Models (LLMs) has become the default practice for improving model performance on a given task. However, performance improvement comes at the cost of training on vast amounts of annotated data which could be…

Computation and Language · Computer Science 2025-04-25 Jose G. Moreno , Jesus Lovon , M'Rick Robin-Charlet , Christine Damase-Michel , Lynda Tamine

Recent advances in medical vision-language models (VLMs) open up remarkable opportunities for clinical applications such as automated report generation, copilots for physicians, and uncertainty quantification. However, despite their…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Xiao Li , Yanfan Zhu , Ruining Deng , Wei-Qi Wei , Yu Wang , Shilin Zhao , Yaohong Wang , Haichun Yang , Yuankai Huo

The characterisation of biomarkers and endophenotypic measures has been a central goal of research in psychiatry over the last years. While most of this research has focused on the identification of biomarkers and endophenotypes, using…

Neurons and Cognition · Quantitative Biology 2017-12-19 Christoph Metzner , Tuomo Mäki-Marttunen , Bartosz Zurowski , Volker Steuber

Tool-use capability is a fundamental component of LLM agents, enabling them to interact with external systems through structured function calls. However, existing research exhibits inconsistent interaction representations, largely overlooks…

Artificial Intelligence · Computer Science 2026-05-26 Yijuan Liang , Xinghao Chen , Yifan Ge , Ziyi Wu , Hao Wu , Changyu Zeng , Wei Xing , Xiaoyu Shen

The large-scale deployment of personalized healthcare agents demands memory mechanisms that are exceptionally precise, safe, and capable of long-term clinical tracking. However, existing benchmarks primarily focus on daily open-domain…

Artificial Intelligence · Computer Science 2026-05-13 Yihao Wang , Haoran Xu , Renjie Gu , Yixuan Ye , Xinyi Chen , Xinyu Mu , Yuan Gao , Chunxiao Guo , Peng Wei , Jinjie Gu , Huan Li , Ke Chen , Lidan Shou

User simulation is important for developing and evaluating human-centered AI, yet current student simulation in educational applications has significant limitations. Existing approaches focus on single learning experiences and do not…

Computers and Society · Computer Science 2026-01-27 Zhengyuan Liu , Stella Xin Yin , Bryan Chen Zhengyu Tan , Roy Ka-Wei Lee , Guimei Liu , Dion Hoe-Lian Goh , Wenya Wang , Nancy F. Chen

Medical large language models (LLMs) achieve impressive performance on standardized benchmarks, yet these evaluations fail to capture the complexity of real clinical encounters where patients exhibit memory gaps, limited health literacy,…

Artificial Intelligence · Computer Science 2026-04-14 Sina Mansouri , Mohit Marvania , Vibhavari Ashok Shihorkar , Han Ngoc Tran , Kazhal Shafiei , Mehrdad Fazli , Yikuan Li , Ziwei Zhu

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Developing an integrated many-to-many framework leveraging multimodal data for multiple tasks is crucial to unifying healthcare applications ranging from diagnoses to operations. In resource-constrained hospital environments, a scalable and…

Machine Learning · Computer Science 2024-06-11 Dimitris Bertsimas , Yu Ma

Background: We present a Patient Simulator that leverages real world patient encounters which cover a broad range of conditions and symptoms to provide synthetic test subjects for development and testing of healthcare agentic models. The…

Computation and Language · Computer Science 2025-06-05 Sina Rashidian , Nan Li , Jonathan Amar , Jong Ha Lee , Sam Pugh , Eric Yang , Geoff Masterson , Myoung Cha , Yugang Jia , Akhil Vaid

Empowered by vast internal knowledge reservoir, the new generation of large language models (LLMs) demonstrate untapped potential to tackle medical tasks. However, there is insufficient effort made towards summoning up a synergic effect…

Computation and Language · Computer Science 2025-05-23 Kexin Shang , Chia-Hsuan Chang , Christopher C. Yang

We introduce Matched Machine Learning, a framework that combines the flexibility of machine learning black boxes with the interpretability of matching, a longstanding tool in observational causal inference. Interpretability is paramount in…

Methodology · Statistics 2023-04-05 Marco Morucci , Cynthia Rudin , Alexander Volfovsky

Since the COVID-19 pandemic, clinicians have seen a large and sustained influx in patient portal messages, significantly contributing to clinician burnout. To the best of our knowledge, there are no large-scale public patient portal…

Artificial Intelligence · Computer Science 2024-11-12 Joseph Gatto , Parker Seegmiller , Timothy E. Burdick , Sarah Masud Preum

Data for human-human spoken dialogues for research and development are currently very limited in quantity, variety, and sources; such data are even scarcer in healthcare. In this work, we investigate fast prototyping of a dialogue…

We present discrete-event simulation models of the operations of primary health centres (PHCs) in the Indian context. Our PHC simulation models incorporate four types of patients seeking medical care: outpatients, inpatients, childbirth…

Computers and Society · Computer Science 2021-09-03 Mohd Shoaib , Varun Ramamohan

Large Language Models (LLMs) have demonstrated considerable potential in general practice. However, existing benchmarks and evaluation frameworks primarily depend on exam-style or simplified question-answer formats, lacking a…

Medical care follows complex clinical pathways that extend beyond isolated physician-patient encounters, emphasizing decision-making and transitions between different stages. Current benchmarks focusing on static exams or isolated dialogues…

Artificial Intelligence · Computer Science 2025-12-15 Yakun Zhu , Zhongzhen Huang , Qianhan Feng , Linjie Mu , Yannian Gu , Shaoting Zhang , Qi Dou , Xiaofan Zhang

Despite substantial progress in healthcare applications driven by large language models (LLMs), growing concerns around data privacy, and limited resources; the small language models (SLMs) offer a scalable and clinically viable solution…

Computation and Language · Computer Science 2025-04-28 Muskan Garg , Shaina Raza , Shebuti Rayana , Xingyi Liu , Sunghwan Sohn

Summaries of medical text shall be faithful by being consistent and factual with source inputs, which is an important but understudied topic for safety and efficiency in healthcare. In this paper, we investigate and improve faithfulness in…

Computation and Language · Computer Science 2023-11-10 Nan Zhang , Yusen Zhang , Wu Guo , Prasenjit Mitra , Rui Zhang
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