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Tumour heterogeneity in breast cancer poses challenges in predicting outcome and response to therapy. Spatial transcriptomics technologies may address these challenges, as they provide a wealth of information about gene expression at the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Md Mamunur Rahaman , Ewan K. A. Millar , Erik Meijering

Understanding 3D fundamental processes is crucial for academic and industrial applications. Nowadays, X-ray time-resolved tomography, or tomoscopy, is a leading technique for in-situ and operando 4D (3D+time) characterization. Despite its…

Super-resolution (SR) is an ill-posed inverse problem which consists in proposing high-resolution images consistent with a given low-resolution one. While most SR algorithms are deterministic, stochastic SR deals with designing a stochastic…

Image and Video Processing · Electrical Eng. & Systems 2023-03-06 Emile Pierret , Bruno Galerne

Spatial transcriptomics is a technology that captures gene expression levels at different spatial locations, widely used in tumor microenvironment analysis and molecular profiling of histopathology, providing valuable insights into…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Junzhuo Liu , Markus Eckstein , Zhixiang Wang , Friedrich Feuerhake , Dorit Merhof

Spatial transcriptomics (ST) maps gene expression within tissue at individual spots, making it a valuable resource for multimodal representation learning. Additionally, ST inherently contains rich hierarchical information both across and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xulin Chen , Junzhou Huang

Restoring low-resolution text images presents a significant challenge, as it requires maintaining both the fidelity and stylistic realism of the text in restored images. Existing text image restoration methods often fall short in hard…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Chenglu Pan , Xiaogang Xu , Ganggui Ding , Yunke Zhang , Wenbo Li , Jiarong Xu , Qingbiao Wu

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

A new statistical model designed for regression analysis with a sparse design matrix is proposed. This new model utilizes the positions of the limited non-zero elements in the design matrix to decompose the regression model into…

Applications · Statistics 2022-01-17 Hsien-Wei Chen

The rapid development of spatial transcriptomics(ST) enables the measurement of gene expression at spatial resolution, making it possible to simultaneously profile the gene expression, spatial locations of spots, and the matched…

Artificial Intelligence · Computer Science 2024-06-19 Changxi Chi , Hang Shi , Qi Zhu , Daoqiang Zhang , Wei Shao

Spatial transcriptomics (ST) enables mapping gene expression with spatial context but is severely affected by high sparsity and technical noise, which conceals true biological signals and hinders downstream analyses. To address these…

Machine Learning · Computer Science 2026-03-10 Sayeem Bin Zaman , Fahim Hafiz , Riasat Azim

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on sub-wavelength features is carried by evanescent waves, never reaching the camera,…

Optics · Physics 2018-12-13 Oren Solomon , Yonina C. Eldar , Maor Mutzafi , Mordechai Segev

Spatial transcriptomics (ST) bridges gene expression and tissue morphology but faces clinical adoption barriers due to technical complexity and prohibitive costs. While computational methods predict gene expression from H&E-stained…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Ziqiao Weng , Yaoyu Fang , Jiahe Qian , Xinkun Wang , Lee AD Cooper , Weidong Cai , Bo Zhou

The rich textual information of large vision-language models (VLMs) combined with the powerful generative prior of pre-trained text-to-image (T2I) diffusion models has achieved impressive performance in single-image super-resolution (SISR).…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Haodong He , Yancheng Bai , Rui Lan , Xu Duan , Lei Sun , Xiangxiang Chu , Gui-Song Xia

This paper addresses the problem of super-resolution: constructing a highly resolved (HR) image from a low resolved (LR) one. Recent unsupervised approaches search the latent space of a StyleGAN pre-trained on HR images, for the image that…

Computer Vision and Pattern Recognition · Computer Science 2023-11-29 Marzieh Gheisari , Auguste Genovesio

Spatial Transcriptomics is a groundbreaking technology that integrates histology images with spatially resolved gene expression profiles. Among the various Spatial Transcriptomics techniques available, Visium has emerged as the most widely…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Daniela Ruiz , Paula Cárdenas , Leonardo Manrique , Daniela Vega , Gabriel M. Mejia , Pablo Arbeláez

Super-resolution (SR) is a technique that allows increasing the resolution of a given image. Having applications in many areas, from medical imaging to consumer electronics, several SR methods have been proposed. Currently, the best…

Computer Vision and Pattern Recognition · Computer Science 2019-12-02 Marija Vella , João F. C. Mota

With the rapid advancement of Spatial Resolved Transcriptomics (SRT) technology, it is now possible to comprehensively measure gene transcription while preserving the spatial context of tissues. Spatial domain identification and gene…

Genomics · Quantitative Biology 2024-08-14 Donghai Fang , Fangfang Zhu , Dongting Xie , Wenwen Min

Single image superresolution has been a popular research topic in the last two decades and has recently received a new wave of interest due to deep neural networks. In this paper, we approach this problem from a different perspective. With…

Computer Vision and Pattern Recognition · Computer Science 2018-10-03 Weifeng Ge , Bingchen Gong , Yizhou Yu

Deep learning-based hyperspectral image super-resolution (SR) methods have achieved great success recently. However, most existing models can not effectively explore spatial information and spectral information between bands simultaneously,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-15 Qi Wang , Qiang Li , Xuelong Li

Single-cell RNA sequencing (scRNA-seq) profiles large numbers of cells but loses spatial context, whereas spatial transcriptomics (ST) preserves partial spatial structure at lower resolution. Most existing integration methods either…

Machine Learning · Computer Science 2026-05-28 Ehtesamul Azim , Muhtasim Noor Alif , Tae Hyun Hwang , Yanjie Fu , Wei Zhang