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Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

Tissues and Organs · Quantitative Biology 2023-03-08 Nen Saito , Shuji Ishihara

One of the defining features of active nematics is that above a critical activity the quiescent state becomes unstable to a distorted, flowing one. We show that spatial variations in activity can fundamentally change the nature of this…

Soft Condensed Matter · Physics 2025-12-15 Alexander J. H. Houston , Michael Grinfeld , Geoff McKay , Nigel J. Mottram

We numerically investigate the morphology and disclination line dynamics of active nematic droplets in three dimensions. Although our model only incorporates the simplest possible form of achiral active stress, active nematic droplets…

Soft Condensed Matter · Physics 2021-04-07 Liam J. Ruske , Julia M. Yeomans

We study how confinement transforms the chaotic dynamics of bulk microtubule-based active nematics into regular spatiotemporal patterns. For weak confinements, multiple continuously nucleating and annihilating topological defects…

A nematic membrane is a sheet with embedded orientational order, which can occur in biological cells, liquid crystal films, manufactured materials, and other soft matter systems. By formulating the free energy of nematic films using tensor…

Soft Condensed Matter · Physics 2009-11-13 John R. Frank , Mehran Kardar

Active nematics are out-of-equilibrium systems in which energy injection at the microscale drives emergent collective behaviors, from spontaneous flows to active turbulence. While the dynamics of these systems have been extensively studied,…

Soft Condensed Matter · Physics 2025-04-15 Ahmet Umut Akduman , Yusuf Sariyar , Giuseppe Negro , Livio Nicola Carenza

The growing interest in active nematics and the emerging evidence of the relevance of topological defects in biology asks for reliable data analysis tools to identify, classify and track such defects in simulation and microscopy data. We…

Soft Condensed Matter · Physics 2020-02-10 Dennis Wenzel , Michael Nestler , Sebastian Reuther , Maximilian Simon , Axel Voigt

The study of liquid crystals at equilibrium has led to fundamental insights into the nature of ordered materials, as well as to practical applications such as display technologies. Active nematics are a fundamentally different class of…

Soft Condensed Matter · Physics 2015-08-19 Stephen J. DeCamp , Gabriel S. Redner , Aparna Baskaran , Michael F. Hagan , Zvonimir Dogic

Topological defects play a key role in two-dimensional active nematics, and a transient role in two-dimensional active polar fluids. In this paper, we study both the transient and long-time behavior of defects in two-dimensional active…

Soft Condensed Matter · Physics 2020-09-24 Farzan Vafa

We study the equilibrium shapes of vesicles, with an in-plane nematic order, using a Monte-Carlo scheme and show that highly curved shapes, like tubes and discs, with a striking similarity to the structures engendered by certain curvature…

Biological Physics · Physics 2012-02-16 N. Ramakrishnan , John H. Ipsen , P. B. Sunil Kumar

We investigate the dynamics of elastic capsules suspended in two-dimensional active nematic fluids using lattice Boltzmann simulations. The capsules, modeled as flexible membranes enclosing active internal regions, exhibit a rich variety of…

Soft Condensed Matter · Physics 2026-04-13 Júlio P. A. Santos , Margarida M. Telo da Gama , Rodrigo C. V. Coelho

A surface in contact with the isotropic phase of a passive liquid crystal can induce nematic order over distances that range from microscopic to macroscopic when the nematic-isotropic interface undergoes an orientational-wetting transition.…

Soft Condensed Matter · Physics 2024-03-18 Rodrigo C. V. Coelho , José A. Moreira , Duarte M. C. Pedro , Margarida M. Telo da Gama

The emergence of nematic order on deformable closed surfaces plays a pivotal role in the morphogenesis of active biological matter, such as the regeneration of Hydra. In this work, we present a continuum model that couples the…

Soft Condensed Matter · Physics 2026-03-10 Gaetano Napoli , Silvia Paparini

Active turbulence in dense active systems is characterized by high vorticity on a length scale that is large compared to that of individual entities. We describe the properties of active turbulence as momentum propagation is screened by…

Soft Condensed Matter · Physics 2014-12-24 Sumesh P. Thampi , Ramin Golestanian , Julia M. Yeomans

Active fluids, such as cytoskeletal filaments, bacterial colonies and epithelial cell layers, exhibit distinctive orientational coherence, often characterized by nematic order and topological defects. By contrast, little is known about…

Soft Condensed Matter · Physics 2021-04-07 Mattia Serra , Linnea Lemma , Luca Giomi , Zvonimir Dogic , L. Mahadevan

Topological defects, which are singular points in a director field, play a major role in shaping active systems. Here, we experimentally study topological defects and the flow patterns around them, that are formed during the highly rapid…

Soft Condensed Matter · Physics 2024-03-20 Victor Yashunsky , Daniel J. G. Pearce , Gil Ariel , Avraham Be'er

We use continuum simulations to study the impact of anisotropic hydrodynamic friction on the emergent flows of active nematics. We show that, depending on whether the active particles align with or tumble in their collectively self-induced…

Soft Condensed Matter · Physics 2020-03-16 Kristian Thijssen , Luuk Metselaar , Julia M. Yeomans , Amin Doostmohammadi

Cell shape changes are largely controlled by the actin cytoskeleton, a dynamic filament network beneath the plasma membrane. Several cell types can form extended free-standing protrusions not supported by an extracellular substrate or…

Soft Condensed Matter · Physics 2025-10-21 Kristiana Mihali , Dennis Wörthmüller , Pierre Sens

We use linear stability analysis and hybrid lattice Boltzmann simulations to study the dynamical behaviour of an active nematic confined in a channel made of viscoelastic material. We find that the quiescent, ordered active nematic is…

Soft Condensed Matter · Physics 2023-12-20 Francesco Mori , Saraswat Bhattacharyya , Julia M. Yeomans , Sumesh P. Thampi

Using a minimal continuum model, we investigate the interplay between circular confinement and substrate friction in active nematics. Upon increasing the friction from low to high, we observe a dynamical phase transition from a circulating…

Soft Condensed Matter · Physics 2023-10-27 Cody D. Schimming , C. J. O. Reichhardt , C. Reichhardt