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Variational quantum circuits have become a widely used tool for performing quantum machine learning (QML) tasks on labeled quantum states. In some specific tasks or for specific variational ans\"atze, one may perform measurements on a…

Quantum Physics · Physics 2026-01-14 Andrey Kardashin , Konstantin Antipin

The minimum accuracy heuristic evaluates quantum feature maps without requiring full quantum support vector machine (QSVM) training. However, the original formulation is computationally expensive, restricted to balanced datasets, and lacks…

In many practical parameter estimation problems, such as coefficient estimation of polynomial regression, the true model is unknown and thus, a model selection step is performed prior to estimation. The data-based model selection step…

Signal Processing · Electrical Eng. & Systems 2024-10-30 Elad Meir , Tirza Routtenberg

Objective: Magnetic Resonance Spectroscopy (MRS) is an important technique for biomedical detection. However, it is challenging to accurately quantify metabolites with proton MRS due to serious overlaps of metabolite signals, imperfections…

Quantum machine learning models have been gaining significant traction within atomistic simulation communities. Conventionally, relative model performances are being assessed and compared using learning curves (prediction error vs. training…

Data Analysis, Statistics and Probability · Physics 2020-09-29 Pascal Pernot , Bing Huang , Andreas Savin

Uncertainty Quantification aims to determine when the prediction from a Machine Learning model is likely to be wrong. Computer Vision research has explored methods for determining epistemic uncertainty (also known as model uncertainty),…

Machine Learning · Computer Science 2024-03-15 Prithviraj Manivannan , Ivo Pascal de Jong , Matias Valdenegro-Toro , Andreea Ioana Sburlea

Diffusion MRI (dMRI) is a valuable tool in the assessment of tissue microstructure. By fitting a model to the dMRI signal it is possible to derive various quantitative features. Several of the most popular dMRI signal models are expansions…

Linear Mixed Model (LMM) is a common statistical approach to model the relation between exposure and outcome while capturing individual variability through random effects. However, this model assumes the homogeneity of the error term's…

Methodology · Statistics 2026-01-27 Vincent Jeanselme , Marco Palma , Jessica K Barrett

Simulation-Based Inference (SBI) is an approach to statistical inference where simulations from an assumed model are used to construct estimators and confidence sets. SBI is often used when the likelihood is intractable and to construct…

Methodology · Statistics 2025-08-05 Lorenzo Tomaselli , Valérie Ventura , Larry Wasserman

We consider estimation of a single unknown parameter embedded in a quantum state. Quantum Cram\'er-Rao bound (QCRB) is the ultimate limit of the mean squared error for any unbiased estimator. While it can be achieved asymptotically for a…

Quantum Physics · Physics 2026-05-06 Zihao Gong , Boulat A. Bash

We investigate the problem of machine learning with mislabeled training data. We try to make the effects of mislabeled training better understood through analysis of the basic model and equations that characterize the problem. This includes…

Machine Learning · Computer Science 2019-09-23 Herbert Gish , Jan Silovsky , Man-Ling Sung , Man-Hung Siu , William Hartmann , Zhuolin Jiang

In some estimation problems, not all the parameters can be identified, which results in singularity of the Fisher Information Matrix (FIM). The Cram\'er-Rao Bound (CRB), which is the inverse of the FIM, is then not defined. To regularize…

Information Theory · Computer Science 2018-07-24 Elisabeth de Carvalho , Dirk Slock

Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects social and communicative behaviors. It emerges in early life and is generally associated with lifelong disabilities. Thus, accurate and early diagnosis…

Image and Video Processing · Electrical Eng. & Systems 2025-02-24 Peiyu Duan , Nicha C. Dvornek , Jiyao Wang , Lawrence H. Staib , James S. Duncan

Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that estimates magnetic susceptibility of tissue from Larmor frequency offset measurements. The generation of QSM requires solving a challenging…

Medical Physics · Physics 2020-08-18 Juan Liu , Kevin M. Koch

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

Artificial Intelligence · Computer Science 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

In quantum metrology, one of the major applications of quantum technologies, the ultimate precision of estimating an unknown parameter is often stated in terms of the Cram\'er-Rao bound. Yet, the latter is no longer guaranteed to carry an…

In machine learning, classification tasks serve as the cornerstone of a wide range of real-world applications. Reliable, trustworthy classification is particularly intricate in biomedical settings, where the ground truth is often inherently…

Machine Learning · Computer Science 2023-11-14 Aina Tersol Montserrat , Alexander R. Loftus , Yael Daihes

Deep learning (DL) is gaining popularity as a parameter estimation method for quantitative MRI. A range of competing implementations have been proposed, relying on either supervised or self-supervised learning. Self-supervised approaches,…

Medical Physics · Physics 2024-01-24 Sean C. Epstein , Timothy J. P. Bray , Margaret Hall-Craggs , Hui Zhang

This paper considers maximum likelihood (ML) estimation in a large class of models with hidden Markov regimes. We investigate consistency of the ML estimator and local asymptotic normality for the models under general conditions which allow…

Statistics Theory · Mathematics 2021-12-07 Demian Pouzo , Zacharias Psaradakis , Martin Sola

Bayesian regression determines model parameters by minimizing the expected loss, an upper bound to the true generalization error. However, the loss ignores misspecification, where models are imperfect. Parameter uncertainties from Bayesian…

Machine Learning · Statistics 2024-11-07 Thomas D Swinburne , Danny Perez