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Selective inference (post-selection inference) is a methodology that has attracted much attention in recent years in the fields of statistics and machine learning. Naive inference based on data that are also used for model selection tends…

Methodology · Statistics 2021-11-25 Yoshiyuki Ninomiya , Yuta Umezu , Ichiro Takeuchi

Computational protein-protein interaction (PPI) prediction techniques can contribute greatly in reducing time, cost and false-positive interactions compared to experimental approaches. Sequence is one of the key and primary information of…

Machine Learning · Computer Science 2022-03-29 Soumyadeep Debnath , Ayatullah Faruk Mollah

The Gini index is a popular inequality measure with many applications in social and economic studies. This paper studies semiparametric inference on the Gini indices of two semicontinuous populations. We characterize the distribution of…

Statistics Theory · Mathematics 2021-06-08 Meng Yuan , Pengfei Li , Changbao Wu

We propose and analyze estimators for statistical functionals of one or more distributions under nonparametric assumptions. Our estimators are based on the theory of influence functions, which appear in the semiparametric statistics…

A new formulation for the proportion of true null hypotheses $(\pi_0)$, based on the sum of all $p$-values and the average of expected $p$-value under the false null hypotheses has been proposed in the current work. This formulation of the…

Statistics Theory · Mathematics 2020-04-07 Aniket Biswas

Artificial intelligence (AI) and machine learning (ML) are increasingly used to generate data for downstream analyses, yet naively treating these predictions as true observations can lead to biased results and incorrect inference. Wang et…

We introduce a new method for estimating the mean of an outcome variable within groups when researchers only observe the average of the outcome and group indicators across a set of aggregation units, such as geographical areas. Existing…

Methodology · Statistics 2026-05-01 Cory McCartan , Shiro Kuriwaki

In this paper, we propose an empirical likelihood-based weighted estimator of regression parameter in quantile regression model with nonignorable missing covariates. The proposed estimator is computationally simple and achieves…

Methodology · Statistics 2017-10-10 Xiaohui Yuan , Xiaogang Dong

This paper describes three methods for carrying out non-asymptotic inference on partially identified parameters that are solutions to a class of optimization problems. Applications in which the optimization problems arise include estimation…

Methodology · Statistics 2022-12-02 Joel L. Horowitz , Sokbae Lee

Negative controls are increasingly used to evaluate the presence of potential unmeasured confounding in observational studies. Beyond the use of negative controls to detect the presence of residual confounding, proximal causal inference…

Methodology · Statistics 2024-06-06 Jiewen Liu , Chan Park , Kendrick Li , Eric J. Tchetgen Tchetgen

Vanilla variational inference finds an optimal approximation to the Bayesian posterior distribution, but even the exact Bayesian posterior is often not meaningful under model misspecification. We propose predictive variational inference…

Machine Learning · Statistics 2026-03-31 Jinlin Lai , Antonio Linero , Yuling Yao

We provide a novel characterization of semiparametric efficiency in a generic supervised learning setting where the outcome mean function -- defined as the conditional expectation of the outcome of interest given the other observed…

Methodology · Statistics 2025-04-22 Harrison H. Li

In this paper, we propose a new semiparametric regression estimator by using a hybrid technique of a parametric approach and a nonparametric penalized spline method. The overall shape of the true regression function is captured by the…

Statistics Theory · Mathematics 2012-02-17 Takuma Yoshida , Kanta Naito

Generalized linear models are flexible tools for the analysis of diverse datasets, but the classical formulation requires that the parametric component is correctly specified and the data contain no atypical observations. To address these…

Methodology · Statistics 2023-04-21 Ioannis Kalogridis , Gerda Claeskens , Stefan Van Aelst

A straightforward application of semi-supervised machine learning to the problem of treatment effect estimation would be to consider data as "unlabeled" if treatment assignment and covariates are observed but outcomes are unobserved.…

Methodology · Statistics 2020-09-15 Andrew Herren , P. Richard Hahn

As artificial intelligence and machine learning tools become more accessible, and scientists face new obstacles to data collection (e.g., rising costs, declining survey response rates), researchers increasingly use predictions from…

Machine Learning · Statistics 2025-12-08 Stephen Salerno , Kentaro Hoffman , Awan Afiaz , Anna Neufeld , Tyler H. McCormick , Jeffrey T. Leek

Quality statistical inference requires a sufficient amount of data, which can be missing or hard to obtain. To this end, prediction-powered inference has risen as a promising methodology, but existing approaches are largely limited to…

Machine Learning · Statistics 2025-05-27 Daniel Csillag , Claudio José Struchiner , Guilherme Tegoni Goedert

Zero-inflated outcomes, where responses are zero with positive probability and otherwise continuous, are common in biomedical, environmental, and social science studies. We propose a conformal prediction based framework that provides…

Despite the risk of misspecification they are tied to, parametric models continue to be used in statistical practice because they are accessible to all. In particular, efficient estimation procedures in parametric models are simple to…

Statistics Theory · Mathematics 2016-09-01 Marco Carone , Alexander R. Luedtke , Mark J. van der Laan

We study semiparametric efficiency bounds and efficient estimation of parameters defined through general moment restrictions with missing data. Identification relies on auxiliary data containing information about the distribution of the…

Statistics Theory · Mathematics 2008-04-04 Xiaohong Chen , Han Hong , Alessandro Tarozzi