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We launch EVA, a vision-centric foundation model to explore the limits of visual representation at scale using only publicly accessible data. EVA is a vanilla ViT pre-trained to reconstruct the masked out image-text aligned vision features…

Computer Vision and Pattern Recognition · Computer Science 2022-12-06 Yuxin Fang , Wen Wang , Binhui Xie , Quan Sun , Ledell Wu , Xinggang Wang , Tiejun Huang , Xinlong Wang , Yue Cao

Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper…

Machine Learning · Computer Science 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

Foundation models have emerged as a powerful approach for processing electronic health records (EHRs), offering flexibility to handle diverse medical data modalities. In this study, we present a comprehensive benchmark that evaluates the…

Machine Learning · Computer Science 2025-07-22 Kunyu Yu , Rui Yang , Jingchi Liao , Siqi Li , Huitao Li , Irene Li , Yifan Peng , Rishikesan Kamaleswaran , Nan Liu

Foundation models have emerged as a powerful paradigm in computational pathology (CPath), enabling scalable and generalizable analysis of histopathological images. While early developments centered on uni-modal models trained solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Xiaohui Chen , Yi He , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Building scalable vision-language models to learn from diverse, multimodal data remains an open challenge. In this paper, we introduce an Efficient Vision-languagE foundation model, namely EVE, which is one unified multimodal Transformer…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Junyi Chen , Longteng Guo , Jia Sun , Shuai Shao , Zehuan Yuan , Liang Lin , Dongyu Zhang

Biological sequences encode fundamental instructions for the building blocks of life, in the form of DNA, RNA, and proteins. Modeling these sequences is key to understand disease mechanisms and is an active research area in computational…

Understanding relationships across multiple imaging modalities is central to neuroimaging research. We introduce the Integrative Variational Autoencoder (InVA), the first hierarchical VAE framework for image-on-image regression in…

Image and Video Processing · Electrical Eng. & Systems 2025-09-15 Bowen Lei , Yeseul Jeon , Rajarshi Guhaniyogi , Aaron Scheffler , Bani Mallick , Alzheimer's Disease Neuroimaging Initiatives

Understanding the relationships among genes, compounds, and their interactions in living organisms remains limited due to technological constraints and the complexity of biological data. Deep learning has shown promise in exploring these…

The integration of AI-assisted biomedical image analysis into clinical practice demands AI-generated findings that are not only accurate but also interpretable to clinicians. However, existing biomedical AI models generally lack the ability…

Gene expression profiling provides critical insights into cellular heterogeneity, biological processes and disease mechanisms. There has been an increasing interest in computational approaches that can predict gene expression directly from…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Shi Pan , Jianan Chen , Maria Secrier

Artificial intelligence (AI) is vital in ophthalmology, tackling tasks like diagnosis, classification, and visual question answering (VQA). However, existing AI models in this domain often require extensive annotation and are task-specific,…

Computer Vision and Pattern Recognition · Computer Science 2024-05-24 Danli Shi , Weiyi Zhang , Xiaolan Chen , Yexin Liu , Jiancheng Yang , Siyu Huang , Yih Chung Tham , Yingfeng Zheng , Mingguang He

Current methods for multimodal medical imaging based disease recognition face two major challenges. First, the prevailing "fusion after unimodal image embedding" paradigm cannot fully leverage the complementary and correlated information in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Qijie Wei , Hailan Lin , Xirong Li

Foundation models are widely employed in medical image analysis, due to their high adaptability and generalizability for downstream tasks. With the increasing number of foundation models being released, model selection has become an…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Fuping Wu , Bartlomiej W. Papiez

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Evaluating foundation models under appropriate adaptation settings is essential for understanding the quality and transferability of the learned representations. Recent EEG foundation models have demonstrated promising transfer capabilities…

Machine Learning · Computer Science 2026-05-28 Aditya Kommineni , Emily Zhou , Kleanthis Avramidis , Tiantian Feng , Shrikanth Narayanan

Electroencephalography (EEG) foundation models have recently emerged as a promising paradigm for brain-computer interfaces (BCIs), aiming to learn transferable neural representations from large-scale heterogeneous recordings. Despite rapid…

Machine Learning · Computer Science 2026-02-06 Dingkun Liu , Yuheng Chen , Zhu Chen , Zhenyao Cui , Yaozhi Wen , Jiayu An , Jingwei Luo , Dongrui Wu

Cancer prognosis is a critical task that involves predicting patient outcomes and survival rates. To enhance prediction accuracy, previous studies have integrated diverse data modalities, such as clinical notes, medical images, and genomic…

Machine Learning · Computer Science 2025-02-04 Jie Peng , Shuang Zhou , Longwei Yang , Yiran Song , Mohan Zhang , Kaixiong Zhou , Feng Xie , Mingquan Lin , Rui Zhang , Tianlong Chen

Developing foundation models in medical imaging requires continuous monitoring of downstream performance. Researchers are burdened with tracking numerous experiments, design choices, and their effects on performance, often relying on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Jan Tagscherer , Sarah de Boer , Lena Philipp , Fennie van der Graaf , Dré Peeters , Joeran Bosma , Lars Leijten , Bogdan Obreja , Ewoud Smit , Alessa Hering

Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet patient responses remain highly variable, and the biological mechanisms underlying resistance are poorly understood. While machine learning models hold promise for…

Machine Learning · Computer Science 2025-08-27 Ifrah Tariq , Ernest Fraenkel

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

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