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Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

As LLMs are increasingly integrated into clinical workflows, their tendency for sycophancy, prioritizing user agreement over factual accuracy, poses significant risks to patient safety. While existing evaluations often rely on subjective…

Computation and Language · Computer Science 2026-01-27 Clément Christophe , Wadood Mohammed Abdul , Prateek Munjal , Tathagata Raha , Ronnie Rajan , Praveenkumar Kanithi

The deployment of Large Language Models (LLMs) in high-stakes medical settings poses a critical AI alignment challenge, as models can inherit and amplify societal biases, leading to significant disparities. Existing fairness evaluation…

Artificial Intelligence · Computer Science 2025-09-03 Shreyash Adappanavar , Krithi Shailya , Gokul S Krishnan , Sriraam Natarajan , Balaraman Ravindran

LLMs have demonstrated impressive performance in answering medical questions, such as achieving passing scores on medical licensing examinations. However, medical board exams or general clinical questions do not capture the complexity of…

Computation and Language · Computer Science 2026-02-19 Hanjie Chen , Zhouxiang Fang , Yash Singla , Mark Dredze

This position paper examines how large language models (LLMs) can support thematic analysis of unstructured clinical transcripts, a widely used but resource-intensive method for uncovering patterns in patient and provider narratives. We…

Computation and Language · Computer Science 2025-09-30 Seungjun Yi , Joakim Nguyen , Terence Lim , Andrew Well , Joseph Skrovan , Mehak Beri , YongGeon Lee , Kavita Radhakrishnan , Liu Leqi , Mia Markey , Ying Ding

Having a unified, coherent taxonomy is essential for effective knowledge representation in domain-specific applications as diverse terminologies need to be mapped to underlying concepts. Traditional manual approaches to taxonomy alignment…

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

Aligning large language models (LLMs) with human preferences has been recognized as the key to improving LLMs' interaction quality. However, in this pluralistic world, human preferences can be diversified due to annotators' different…

Artificial Intelligence · Computer Science 2024-10-08 Dun Zeng , Yong Dai , Pengyu Cheng , Longyue Wang , Tianhao Hu , Wanshun Chen , Nan Du , Zenglin Xu

Ethical frameworks for the use of natural language processing (NLP) are urgently needed to shape how large language models (LLMs) and similar tools are used for healthcare applications. Healthcare faces existing challenges including the…

Computation and Language · Computer Science 2024-01-25 Maria Antoniak , Aakanksha Naik , Carla S. Alvarado , Lucy Lu Wang , Irene Y. Chen

Large language models (LLMs) have exhibited impressive reasoning abilities on a wide range of complex tasks. However, enhancing these capabilities through post-training remains resource intensive, particularly in terms of data and…

Artificial Intelligence · Computer Science 2025-08-13 Shuo Cai , Su Lu , Qi Zhou , Kejing Yang , Zhijie Sang , Congkai Xie , Hongxia Yang

Large language models (LLMs) are increasingly used for medical consultation and health information support. In this high-stakes setting, safety depends not only on medical knowledge, but also on how models respond when patient inputs are…

Computation and Language · Computer Science 2026-04-01 Yahan Li , Xinyi Jie , Wanjia Ruan , Xubei Zhang , Huaijie Zhu , Yicheng Gao , Chaohao Du , Ruishan Liu

The need for robust and diverse data sets to train clinical large language models (cLLMs) is critical given that currently available public repositories often prove too limited in size or scope for comprehensive medical use. While resources…

Large language models (LLMs) have achieved expert-level performance on standardized examinations, yet multiple-choice accuracy poorly reflects real-world clinical utility and safety. As patients and clinicians increasingly use LLMs for…

Large language models (LLMs) have shown amazing capabilities in knowledge memorization and the present. However, when it comes to domain-specific knowledge and downstream tasks like medical, general LLMs are often unable to give precise…

Computation and Language · Computer Science 2024-06-06 Maojun Sun

As large language models (LLMs) develop increasingly sophisticated capabilities and find applications in medical settings, it becomes important to assess their medical safety due to their far-reaching implications for personal and public…

Artificial Intelligence · Computer Science 2024-10-11 Tessa Han , Aounon Kumar , Chirag Agarwal , Himabindu Lakkaraju

Summarizing consumer health questions (CHQs) can ease communication in healthcare, but unfaithful summaries that misrepresent medical details pose serious risks. We propose a framework that combines TextRank-based sentence extraction and…

Computation and Language · Computer Science 2025-11-17 Ajwad Abrar , Nafisa Tabassum Oeshy , Prianka Maheru , Farzana Tabassum , Tareque Mohmud Chowdhury

Current large language models (LLMs) generally show a significant performance gap in alignment between English and other languages. To bridge this gap, existing research typically leverages the model's responses in English as a reference to…

Computation and Language · Computer Science 2025-09-16 Xue Zhang , Yunlong Liang , Fandong Meng , Songming Zhang , Yufeng Chen , Jinan Xu , Jie Zhou

The explainability of recommendation systems is crucial for enhancing user trust and satisfaction. Leveraging large language models (LLMs) offers new opportunities for comprehensive recommendation logic generation. However, in existing…

Information Retrieval · Computer Science 2024-07-04 Hongke Zhao , Songming Zheng , Likang Wu , Bowen Yu , Jing Wang

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska
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