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We present a joint Speech and Language Model (SLM), a multitask, multilingual, and dual-modal model that takes advantage of pretrained foundational speech and language models. SLM freezes the pretrained foundation models to maximally…

We report a flexible multi-modal mechanics language model, MeLM, applied to solve various nonlinear forward and inverse problems, that can deal with a set of instructions, numbers and microstructure data. The framework is applied to various…

Materials Science · Physics 2023-10-20 Markus J. Buehler

Pretrained language models have achieved state-of-the-art performance when adapted to a downstream NLP task. However, theoretical analysis of these models is scarce and challenging since the pretraining and downstream tasks can be very…

Machine Learning · Computer Science 2022-04-22 Colin Wei , Sang Michael Xie , Tengyu Ma

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Grammar plays a critical role in natural language processing and text/code generation by enabling the definition of syntax, the creation of parsers, and guiding structured outputs. Although large language models (LLMs) demonstrate…

Artificial Intelligence · Computer Science 2025-06-03 Weizhi Tang , Yixuan Li , Chris Sypherd , Elizabeth Polgreen , Vaishak Belle

We propose a novel convolutional architecture, named $gen$CNN, for word sequence prediction. Different from previous work on neural network-based language modeling and generation (e.g., RNN or LSTM), we choose not to greedily summarize the…

Computation and Language · Computer Science 2015-04-27 Mingxuan Wang , Zhengdong Lu , Hang Li , Wenbin Jiang , Qun Liu

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

The influenza virus hemagglutinin is an important part of the virus attachment to the host cells. The hemagglutinin proteins are one of the genetic regions of the virus with a high potential for mutations. Due to the importance of…

Infectious diseases are a significant public health concern globally, and extracting relevant information from scientific literature can facilitate the development of effective prevention and treatment strategies. However, the large amount…

Computation and Language · Computer Science 2023-03-24 Shaina Raza , Syed Raza Bashir

Diffusion language models (DLMs) have strong theoretical efficiency but are limited by fixed-length decoding and incompatibility with key-value (KV) caches. Block diffusion mitigates these issues, yet still enforces a fixed block size and…

Computation and Language · Computer Science 2025-09-30 Yangzhou Liu , Yue Cao , Hao Li , Gen Luo , Zhe Chen , Weiyun Wang , Xiaobo Liang , Biqing Qi , Lijun Wu , Changyao Tian , Yanting Zhang , Yuqiang Li , Tong Lu , Yu Qiao , Jifeng Dai , Wenhai Wang

Diffusion models have achieved great success in modeling continuous data modalities such as images, audio, and video, but have seen limited use in discrete domains such as language. Recent attempts to adapt diffusion to language have…

Computation and Language · Computer Science 2023-11-08 Justin Lovelace , Varsha Kishore , Chao Wan , Eliot Shekhtman , Kilian Q. Weinberger

Language models generate reasoning sequentially, preventing them from decoupling irrelevant exploration paths during search. We introduce Tree-Structured Language Modeling (TSLM), which uses special tokens to encode branching structure,…

Computation and Language · Computer Science 2026-02-02 Doyoung Kim , Jaehyeok Doo , Minjoon Seo

Given usefulness of protein language models (LMs) in structure and functional inference, RNA LMs have received increased attentions in the last few years. However, these RNA models are often not compared against the same standard. Here, we…

Biomolecules · Quantitative Biology 2025-05-15 He Wang , Yikun Zhang , Jie Chen , Jian Zhan , Yaoqi Zhou

Large Language Models (LLMs) have delivered impressive results in language understanding, generation, reasoning, and pushes the ability boundary of multimodal models. Transformer models, as the foundation of modern LLMs, offer a strong…

Computation and Language · Computer Science 2025-08-14 Weigao Sun , Jiaxi Hu , Yucheng Zhou , Jusen Du , Disen Lan , Kexin Wang , Tong Zhu , Xiaoye Qu , Yu Zhang , Xiaoyu Mo , Daizong Liu , Yuxuan Liang , Wenliang Chen , Guoqi Li , Yu Cheng

The high incidence and mortality rates associated with respiratory diseases underscores the importance of early screening. Machine learning models can automate clinical consultations and auscultation, offering vital support in this area.…

Machine Learning · Computer Science 2024-10-10 Yuwei Zhang , Tong Xia , Aaqib Saeed , Cecilia Mascolo

Embodied Vision-Language Models (VLMs) have demonstrated impressive performance and generalization in robotics, particularly within Vision-Language-Action frameworks. However, a significant gap remains between the high-level semantic focus…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Ruowen Zhao , Bangguo Li , Zuyan Liu , Yinan Liang , Junliang Ye , Fangfu Liu , Diankun Wu , Zhengyi Wang , Xumin Yu , Yongming Rao , Han Hu , Jun Zhu

Representation learning for text via pretraining a language model on a large corpus has become a standard starting point for building NLP systems. This approach stands in contrast to autoencoders, also trained on raw text, but with the…

Computation and Language · Computer Science 2021-09-14 Ivan Montero , Nikolaos Pappas , Noah A. Smith

The impact of Transformer-based language models has been unprecedented in Natural Language Processing (NLP). The success of such models has also led to their adoption in other fields including bioinformatics. Taking this into account, this…

Machine Learning · Computer Science 2025-07-21 Nimisha Ghosh , Daniele Santoni , Debaleena Nawn , Eleonora Ottaviani , Giovanni Felici

Antibody therapeutics are among the most successful modern medicines, yet computationally designing antibodies with desirable binding and developability properties remains challenging. While protein language models (pLMs) have emerged as…

Machine Learning · Computer Science 2026-05-11 Justin Sanders , Luca Giancardo , Lan Guo , Yue Zhao , Kemal Sonmez , Nina Cheng , Melih Yilmaz

Protein language models are a powerful tool for learning protein representations through pre-training on vast protein sequence datasets. However, traditional protein language models lack explicit structural supervision, despite its…

Biomolecules · Quantitative Biology 2024-02-09 Zuobai Zhang , Jiarui Lu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang
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