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Inferring dynamical models from low-resolution temporal data continues to be a significant challenge in biophysics, especially within transcriptomics, where separating molecular programs from noise remains an important open problem. We…

Machine Learning · Computer Science 2023-10-05 Victor Chardès , Suryanarayana Maddu , Michael J. Shelley

Deep learning methods for accelerated MRI achieve state-of-the-art results but largely ignore additional speedups possible with noncartesian sampling trajectories. To address this gap, we created a generative diffusion model-based…

Artificial Intelligence · Computer Science 2024-10-02 Trevor J. Chan , Chamith S. Rajapakse

This paper presents DDTracking, a novel deep generative framework for diffusion MRI tractography that formulates streamline propagation as a conditional denoising diffusion process. In DDTracking, we introduce a dual-pathway encoding…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Yijie Li , Wei Zhang , Xi Zhu , Ye Wu , Yogesh Rathi , Lauren J. O'Donnell , Fan Zhang

Functional differentiation in the brain emerges as distinct regions specialize and is key to understanding brain function as a complex system. Previous research has modeled this process using artificial neural networks with specific…

Neurons and Cognition · Quantitative Biology 2025-11-17 Yuki Tomoda , Ichiro Tsuda , Yutaka Yamaguti

Diffusion-weighted magnetic resonance imaging (dMRI) allows non-invasive investigation of whole-brain connectivity, which can potentially help to reveal the brain's global network architecture and abnormalities involved in neurological and…

Functional magnetic resonance imaging (fMRI) data provides information concerning activity in the brain and in particular the interactions between brain regions. Resting state fMRI data is widely used for inferring connectivities in the…

Applications · Statistics 2019-03-04 Christina Stoehr , John A D Aston , Claudia Kirch

This work introduces the generative fractional diffusion model for protein generation (ProT-GFDM), a novel generative framework that employs fractional stochastic dynamics for protein backbone structure modeling. This approach builds on the…

Quantitative Methods · Quantitative Biology 2025-05-01 Xiao Liang , Wentao Ma , Eric Paquet , Herna Lydia Viktor , Wojtek Michalowski

In a Networked Dynamical System (NDS), each node is a system whose dynamics are coupled with the dynamics of neighboring nodes. The global dynamics naturally builds on this network of couplings and it is often excited by a noise input with…

Machine Learning · Computer Science 2023-12-19 Augusto Santos , Diogo Rente , Rui Seabra , José M. F. Moura

Functional brain graphs are often characterized with separate graph-theoretic or spectral descriptors, overlooking how these properties covary and partially overlap across brains and conditions. We anticipate that dense, weighted functional…

Neurons and Cognition · Quantitative Biology 2025-11-07 Subati Abulikemu , Tiago Azevedo , Michail Mamalakis , John Suckling

In many systems we can describe emergent macroscopic behaviors, quantitatively, using models that are much simpler than the underlying microscopic interactions; we understand the success of this simplification through the renormalization…

Biological Physics · Physics 2019-01-01 Leenoy Meshulam , Jeffrey L. Gauthier , Carlos D. Brody , David W. Tank , William Bialek

Large-scale neural networks have demonstrated remarkable performance in different domains like vision and language processing, although at the cost of massive computation resources. As illustrated by compression literature, structural model…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Tianjin Huang , Fang Meng , Li Shen , Fan Liu , Yulong Pei , Mykola Pechenizkiy , Shiwei Liu , Tianlong Chen

Network renormalization has traditionally relied on spatial adjacency-grouping nearby nodes together, but this approach fails to capture the dynamical correlations that govern system-wide behavior in scale-free networks. We present a…

Physics and Society · Physics 2025-10-21 Cook Hyun Kim , B. Kahng

Removing the shape noise from the observed weak lensing field, i.e., denoising, enhances the potential of WL by accessing information at small scales where the shape noise dominates without denoising. We utilise two machine learning (ML)…

Cosmology and Nongalactic Astrophysics · Physics 2026-05-13 Shohei D. Aoyama , Ken Osato , Masato Shirasaki

We propose and illustrate an approach to coarse-graining the dynamics of evolving networks (networks whose connectivity changes dynamically). The approach is based on the equation-free framework: short bursts of detailed network evolution…

Social and Information Networks · Computer Science 2012-02-28 Katherine A. Bold , Karthikeyan Rajendran , Balázs Ráth , Ioannis G. Kevrekidis

While measurement advances now allow extensive surveys of gene activity (large numbers of genes across many samples), interpretation of these data is often confounded by noise -- expression counts can differ strongly across samples due to…

The CNNs have achieved a state-of-the-art performance in many applications. Recent studies illustrate that CNN's recognition accuracy drops drastically if images are noise corrupted. We focus on the problem of robust recognition accuracy of…

Computer Vision and Pattern Recognition · Computer Science 2020-04-10 Sergey Tarasenko , Fumihiko Takahashi

Real-space mutual information (RSMI) was shown to be an important quantity, formally and from a numerical standpoint, in finding coarse-grained descriptions of physical systems. It very generally quantifies spatial correlations, and can…

Statistical Mechanics · Physics 2021-12-09 Doruk Efe Gökmen , Zohar Ringel , Sebastian D. Huber , Maciej Koch-Janusz

We systematically derive an exact coarse-grained description for interacting particles with thermodynamically consistent stochastic dynamics, applicable across different observation scales, the mesoscopic and the macroscopic. We implement…

Statistical Mechanics · Physics 2026-03-05 Atul Tanaji Mohite , Heiko Rieger

The learning capability of a neural network improves with increasing depth at higher computational costs. Wider layers with dense kernel connectivity patterns furhter increase this cost and may hinder real-time inference. We propose feature…

Machine Learning · Computer Science 2016-11-01 Sajid Anwar , Wonyong Sung

We tackle the problem of sampling from intractable high-dimensional density functions, a fundamental task that often appears in machine learning and statistics. We extend recent sampling-based approaches that leverage controlled stochastic…

Machine Learning · Computer Science 2024-03-12 Dinghuai Zhang , Ricky T. Q. Chen , Cheng-Hao Liu , Aaron Courville , Yoshua Bengio