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Heart transplantation is a viable path for patients suffering from advanced heart failure, but this lifesaving option is severely limited due to donor shortage. Although the current allocation policy was recently revised in 2018, a major…

Machine Learning · Computer Science 2025-12-16 Ioannis Anagnostides , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

The allocation of scarce donor organs constitutes one of the most consequential algorithmic challenges in healthcare. While the field is rapidly transitioning from rigid, rule-based systems to machine learning and data-driven optimization,…

Machine Learning · Computer Science 2026-05-27 Ioannis Anagnostides , Itai Zilberstein , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

Organ transplantation is often the last resort for treating end-stage illness, but the probability of a successful transplantation depends greatly on compatibility between donors and recipients. Current medical practice relies on coarse…

Machine Learning · Statistics 2021-02-03 Can Xu , Ahmed M. Alaa , Ioana Bica , Brent D. Ershoff , Maxime Cannesson , Mihaela van der Schaar

Online matching has been a mainstay in domains such as Internet advertising and organ allocation, but practical algorithms often lack strong theoretical guarantees. We take an important step toward addressing this by developing new online…

Machine Learning · Computer Science 2026-02-09 Itai Zilberstein , Ioannis Anagnostides , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

Kidney transplantation is the preferred treatment for end-stage renal disease, yet the scarcity of donors and inefficiencies in allocation systems create major bottlenecks, resulting in prolonged wait times and alarming mortality rates.…

Computer Science and Game Theory · Computer Science 2024-10-15 Sean Berry , Berk Gorgulu , Sait Tunc , Mucahit Cevik , Matthew J Ellis

We propose a simulation-optimization-based methodology to improve the way that organ transplant offers are made to potential recipients. Our policy can be applied to all types of organs, is implemented starting at the local level, is…

Medical Physics · Physics 2022-12-01 Ignacio Erazo , David Goldsman , Pinar Keskinocak , Joel Sokol

The beneficial effects of treatments vary across individuals in most studies. Treatment heterogeneity motivates practitioners to search for the optimal policy based on personal characteristics. A long-standing common practice in policy…

Statistics Theory · Mathematics 2025-01-06 Xuqiao Li , Ying Yan

A kidney exchange program, also called a kidney paired donation program, can be viewed as a repeated, dynamic trading and allocation mechanism. This suggests that a dynamic algorithm for transplant exchange selection may have superior…

Optimization and Control · Mathematics 2023-09-26 Margarida Carvalho , Alison Caulfield , Yi Lin , Adrian Vetta

Organ transplants can improve the life expectancy and quality of life for the recipient but carries the risk of serious post-operative complications, such as septic shock and organ rejection. The probability of a successful transplant…

Machine Learning · Computer Science 2016-11-15 Jinsung Yoon , Ahmed M. Alaa , Martin Cadeiras , Mihaela van der Schaar

We study the problem of allocating scarce societal resources of different types (e.g., permanent housing, deceased donor kidneys for transplantation, ventilators) to heterogeneous allocatees on a waitlist (e.g., people experiencing…

Optimization and Control · Mathematics 2025-08-13 Bill Tang , Çağıl Koçyiğit , Eric Rice , Phebe Vayanos

Online matching problems arise in many complex systems, from cloud services and online marketplaces to organ exchange networks, where timely, principled decisions are critical for maintaining high system performance. Traditional heuristics…

Machine Learning · Statistics 2025-10-09 Chiara Mignacco , Matthieu Jonckheere , Gilles Stoltz

Currently in the United States, lung transplantations are allocated to candidates according to the candidates' Lung Allocation Score (LAS). The LAS is an ad-hoc ranking system for patients' priorities of transplantation. The goal of this…

Applications · Statistics 2020-04-20 Jingjing Zou , David J. Lederer , Daniel Rabinowitz

We study the allocation of deceased-donor lungs to patients in need of a transplant. Patients make sequential decisions in an order dictated by a priority policy. Using data from a prominent Organ Procurement Organization in the United…

General Economics · Economics 2024-11-19 Laura Doval , Federico Echenique Wanying Huang , Yi Xin

We study a continuous-time, infinite-horizon dynamic bipartite matching problem. Suppliers arrive according to a Poisson process; while waiting, they may abandon the queue at a uniform rate. Customers on the other hand must be matched upon…

Data Structures and Algorithms · Computer Science 2025-06-03 Alireza AmaniHamedani , Ali Aouad , Amin Saberi

Equipping current decision-making tools with notions of fairness, equitability, or other ethically motivated outcomes, is one of the top priorities in recent research efforts in machine learning, AI, and optimization. In this paper, we…

Optimization and Control · Mathematics 2022-06-27 Andrea Simonetto , Ivano Notarnicola

Imitation learning enables autonomous agents to learn from human examples, without the need for a reward signal. Still, if the provided dataset does not encapsulate the task correctly, or when the task is too complex to be modeled, such…

Artificial Intelligence · Computer Science 2024-06-10 Federico Malato , Ville Hautamaki

Kidney transplants are sharply overdemanded in the United States. A recent innovation to address organ shortages is a kidney exchange, in which willing but medically incompatible patient-donor pairs swap donors so that two successful…

Computer Science and Game Theory · Computer Science 2019-12-24 Irena Gao

AI algorithms increasingly make decisions that impact entire groups of humans. Since humans tend to hold varying and even conflicting preferences, AI algorithms responsible for making decisions on behalf of such groups encounter the problem…

Artificial Intelligence · Computer Science 2020-06-18 Rachel Freedman

Learning in a lifelong setting, where the dynamics continually evolve, is a hard challenge for current reinforcement learning algorithms. Yet this would be a much needed feature for practical applications. In this paper, we propose an…

Machine Learning · Computer Science 2021-12-14 Pierre Liotet , Francesco Vidaich , Alberto Maria Metelli , Marcello Restelli

We consider a model for repeated stochastic matching where compatibility is probabilistic, is realized the first time agents are matched, and persists in the future. Such a model has applications in the gig economy, kidney exchange, and…

Computer Science and Game Theory · Computer Science 2021-06-15 Mobin Y. Jeloudar , Irene Lo , Tristan Pollner , Amin Saberi
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