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Functional magnetic resonance imaging (fMRI) is a powerful tool for probing brain function, yet reliable clinical diagnosis is hampered by low signal-to-noise ratios, inter-subject variability, and the limited frequency awareness of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Junhao Jia , Yifei Sun , Yunyou Liu , Cheng Yang , Changmiao Wang , Feiwei Qin , Yong Peng , Wenwen Min

Data scarcity is a notable problem, especially in the medical domain, due to patient data laws. Therefore, efficient Pre-Training techniques could help in combating this problem. In this paper, we demonstrate that a model trained on the…

Machine Learning · Computer Science 2022-12-01 Zafar Iqbal , Usman Mahmood , Zening Fu , Sergey Plis

Brain decoding, aiming to identify the brain states using neural activity, is important for cognitive neuroscience and neural engineering. However, existing machine learning methods for fMRI-based brain decoding either suffer from low…

Neurons and Cognition · Quantitative Biology 2022-10-13 Ziyuan Ye , Youzhi Qu , Zhichao Liang , Mo Wang , Quanying Liu

Edge time series are increasingly used in brain functional imaging to study the node functional connectivity (nFC) dynamics at the finest temporal resolution while avoiding sliding windows. Here, we lay the mathematical foundations for the…

Neurons and Cognition · Quantitative Biology 2022-07-15 Leonardo Novelli , Adeel Razi

Resting-state functional magnetic resonance imaging (fMRI) has emerged as a pivotal tool for revealing intrinsic brain network connectivity and identifying neural biomarkers of neuropsychiatric conditions. However, classical self-attention…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Junghoon Justin Park , Jungwoo Seo , Sangyoon Bae , Samuel Yen-Chi Chen , Huan-Hsin Tseng , Jiook Cha , Shinjae Yoo

Under the framework of network-based neurodegeneration, brain functional connectome (FC)-based Graph Neural Networks (GNN) have emerged as a valuable tool for the diagnosis and prognosis of neurodegenerative diseases such as Alzheimer's…

Neurons and Cognition · Quantitative Biology 2023-07-14 Zijian Dong , Yilei Wu , Yu Xiao , Joanna Su Xian Chong , Yueming Jin , Juan Helen Zhou

Functional magnetic resonance imaging or functional MRI (fMRI) is a non-invasive way to assess brain activity by detecting changes associated with blood flow. In this work, we propose a full Bayesian procedure to analyze fMRI data for…

Mild cognitive impairment (MCI) is characterized by subtle changes in cognitive functions, often associated with disruptions in brain connectivity. The present study introduces a novel fine-grained analysis to examine topological…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Ninad Aithal , Debanjali Bhattacharya , Neelam Sinha , Thomas Gregor Issac

The extraction of brain functioning features is a crucial step in the definition of brain-computer interfaces (BCIs). In the last decade, functional connectivity (FC) estimators have been increasingly explored based on their ability to…

Neurons and Cognition · Quantitative Biology 2019-12-06 Tiziana Cattai , Stefania Colonnese , Marie-Constance Corsi , Danielle S. Bassett , Gaetano Scarano , Fabrizio De Vico Fallani

Large, open-source consortium datasets have spurred the development of new and increasingly powerful machine learning approaches in brain connectomics. However, one key question remains: are we capturing biologically relevant and…

Dynamic Causal Modelling (DCM) is the predominant method for inferring effective connectivity from neuroimaging data. In the 15 years since its introduction, the neural models and statistical routines in DCM have developed in parallel,…

Quantitative Methods · Quantitative Biology 2019-07-15 Peter Zeidman , Amirhossein Jafarian , Nadège Corbin , Mohamed L. Seghier , Adeel Razi , Cathy J. Price , Karl J. Friston

Dynamic functional connectivity (dFC) is ubiquitously observed in the brain, but why functional networks should remain dynamic even at rest is unclear. We asked whether temporal reconfiguration becomes advantageous when keeping a functional…

Biological Physics · Physics 2026-04-14 Simachew Abebe Mengiste , Demian Battaglia

For neurological disorders and diseases, functional and anatomical connectomes of the human brain can be used to better inform targeted interventions and treatment strategies. Functional magnetic resonance imaging (fMRI) is a non-invasive…

Methodology · Statistics 2023-07-03 Matt Ryan , Gary Glonek , Jono Tuke , Melissa Humphries

Alzheimer's disease (AD) is a neurodegenerative disorder marked by memory loss and cognitive decline, making early detection vital for timely intervention. However, early diagnosis is challenging due to the heterogeneous presentation of…

Neurons and Cognition · Quantitative Biology 2025-09-24 Ali Khazaee , Abdolreza Mohammadi , Ruairi O'Reilly

Functional MRI is a neuroimaging technique that analyzes the functional activity of the brain by measuring blood-oxygen-level-dependent signals throughout the brain. The derived functional features can be used for investigating brain…

Neurons and Cognition · Quantitative Biology 2026-02-16 Giorgio Dolci , Silvia Saglia , Lorenza Brusini , Vince D. Calhoun , Ilaria Boscolo Galazzo , Gloria Menegaz

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

Dynamic functional connectivity (dFC) derived from resting-state functional magnetic resonance imaging (fMRI) has been extensively utilized in brain science research. The sliding window correlation (SWC) method is a widely used approach for…

Neurons and Cognition · Quantitative Biology 2026-03-27 Jinlong Hu , Jiatong Huang , Zijian Cai

Integrating the brain structural and functional connectivity features is of great significance in both exploring brain science and analyzing cognitive impairment clinically. However, it remains a challenge to effectively fuse structural and…

Neurons and Cognition · Quantitative Biology 2023-05-25 Qiankun Zuo , Baiying Lei , Ning Zhong , Yi Pan , Shuqiang Wang

Combining Functional MRI (fMRI) data across different subjects and datasets is crucial for many neuroscience tasks. Relying solely on shared anatomy for brain-to-brain mapping is inadequate. Existing functional transformation methods thus…

Neurons and Cognition · Quantitative Biology 2025-03-18 Navve Wasserman , Roman Beliy , Roy Urbach , Michal Irani

Time Varying Functional Connectivity (TVFC) investigates how the interactions among brain regions vary over the course of an fMRI experiment. The transitions between different individual connectivity states can be modulated by changes in…