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One of the challenges of studying common neurological disorders is disease heterogeneity including differences in causes, neuroimaging characteristics, comorbidities, or genetic variation. Normative modelling has become a popular method for…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Ana Lawry Aguila , James Chapman , Andre Altmann

The number of samples in structural brain MRI studies is often too small to properly train deep learning models. Generative models show promise in addressing this issue by effectively learning the data distribution and generating…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Wei Peng , Tian Xia , Fabio De Sousa Ribeiro , Tomas Bosschieter , Ehsan Adeli , Qingyu Zhao , Ben Glocker , Kilian M. Pohl

Psychiatric disorders have historically been classified using symptom information alone. With the advent of new technologies that allowed researchers to investigate brain mechanisms more directly, interest in the mechanistic rationale…

Neurons and Cognition · Quantitative Biology 2020-07-02 Lucas Miranda , Riya Paul , Benno Pütz , Bertram Müller-Myhsok

Causal modeling has long been an attractive topic for many researchers and in recent decades there has seen a surge in theoretical development and discovery algorithms. Generally discovery algorithms can be divided into two approaches:…

Machine Learning · Statistics 2017-02-06 Ridho Rahmadi , Perry Groot , Marianne Heins , Hans Knoop , Tom Heskes

This paper introduces a new structural causal model tailored for representing threshold-based IT systems and presents a new algorithm designed to rapidly detect root causes of anomalies in such systems. When root causes are not causally…

Artificial Intelligence · Computer Science 2024-07-30 Lei Zan , Charles K. Assaad , Emilie Devijver , Eric Gaussier , Ali Aït-Bachir

Resting-state functional magnetic resonance imaging (rs-fMRI) can reflect spontaneous neural activities in brain and is widely used for brain disorder analysis.Previous studies propose to extract fMRI representations through diverse…

Quantitative Methods · Quantitative Biology 2023-06-27 Qianqian Wang , Wei Wang , Yuqi Fang , P. -T. Yap , Hongtu Zhu , Hong-Jun Li , Lishan Qiao , Mingxia Liu

Understanding how humans process visual information is one of the crucial steps for unraveling the underlying mechanism of brain activity. Recently, this curiosity has motivated the fMRI-to-image reconstruction task; given the fMRI data…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Jaehoon Joo , Taejin Jeong , Seongjae Hwang

Current machine learning approaches to medical diagnosis often rely on correlational patterns between symptoms and diseases, risking misdiagnoses when symptoms are ambiguous or common across multiple conditions. In this work, we move beyond…

Machine Learning · Computer Science 2025-03-26 Mehul Shetty , Connor Jordan

Searching for biomarkers has been a chief pursuit of the field of psychiatry. Toward this end, studies have catalogued candidate resting-state biomarkers in nearly all forms of mental disorder. However, it is becoming increasingly clear…

Neurons and Cognition · Quantitative Biology 2020-06-09 Linden Parkes , Theodore D. Satterthwaite , Danielle S. Bassett

We introduce a probabilistic generative model for disentangling spatio-temporal disease trajectories from series of high-dimensional brain images. The model is based on spatio-temporal matrix factorization, where inference on the sources is…

Machine Learning · Statistics 2019-10-11 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Extracting causal relationships from a medical case report is essential for comprehending the case, particularly its diagnostic process. Since the diagnostic process is regarded as a bottom-up inference, causal relationships in cases…

Computation and Language · Computer Science 2025-03-04 Sakiko Yahata , Zhen Wan , Fei Cheng , Sadao Kurohashi , Hisahiko Sato , Ryozo Nagai

Root Cause Analysis (RCA) is essential for pinpointing the root causes of failures in microservice systems. Traditional data-driven RCA methods are typically limited to offline applications due to high computational demands, and existing…

Machine Learning · Computer Science 2025-12-17 Lecheng Zheng , Zhengzhang Chen , Haifeng Chen

In the clinical treatment of mood disorders, the complex behavioral symptoms presented by patients and variability of patient response to particular medication classes can create difficulties in providing fast and reliable treatment when…

Machine Learning · Computer Science 2024-02-13 Bradley T. Baker , Mustafa S. Salman , Zening Fu , Armin Iraji , Elizabeth Osuch , Jeremy Bockholt , Vince D. Calhoun

Groove sensations arise from rhythmic structures that evoke an urge to move in response to music. While syncopation has been extensively studied in groove perception, the neural mechanisms underlying low-frequency groove remain…

Neurons and Cognition · Quantitative Biology 2025-03-05 Chen-Gia Tsai , Chia-Wei Li

On the promise that if human users know the cause of an output, it would enable them to grasp the process responsible for the output, and hence provide understanding, many explainable methods have been proposed to indicate the cause for the…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Armando Villegas-Jimenez , Daniel Flores-Araiza , Francisco Lopez-Tiro , Gilberto Ochoa-Ruiz andand Christian Daul

Detecting unsafe driving states, such as stress, drowsiness, and fatigue, is an important component of ensuring driving safety and an essential prerequisite for automatic intervention systems in vehicles. These concerning conditions are…

Signal Processing · Electrical Eng. & Systems 2022-10-31 Kleanthis Avramidis , Tiantian Feng , Digbalay Bose , Shrikanth Narayanan

Causal terminology is often introduced in the interpretation of encoding and decoding models trained on neuroimaging data. In this article, we investigate which causal statements are warranted and which ones are not supported by empirical…

Causal discovery algorithms aim at untangling complex causal relationships from data. Here, we study causal discovery and inference methods based on staged tree models, which can represent complex and asymmetric causal relationships between…

Methodology · Statistics 2023-03-02 Manuele Leonelli , Gherardo Varando

Structural causal models postulate noisy functional relations among a set of interacting variables. The causal structure underlying each such model is naturally represented by a directed graph whose edges indicate for each variable which…

Statistics Theory · Mathematics 2022-03-15 David Strieder , Tobias Freidling , Stefan Haffner , Mathias Drton

Brain metabolism is controlled by complex regulation mechanisms. As part of their nature many complex systems show scaling behavior in their timeseries data. Corresponding scaling exponents can sometimes be used to characterize these…

Condensed Matter · Physics 2007-05-23 Stefan Thurner , Christian Windischberger , Ewald Moser , Markus Barth