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Understanding symptom-image associations is crucial for clinical reasoning. However, existing medical multimodal models often rely on simple one-to-one hard labeling, oversimplifying clinical reality where symptoms relate to multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 You-Kyoung Na , Yeong-Jun Cho

Depression is a widespread mental disorder that affects millions worldwide. While automated depression assessment shows promise, most studies rely on limited or non-clinically validated data, and often prioritize complex model design over…

Computation and Language · Computer Science 2025-08-07 Zhuang Chen , Guanqun Bi , Wen Zhang , Jiawei Hu , Aoyun Wang , Xiyao Xiao , Kun Feng , Minlie Huang

Emotion is often described as something people 'feel' in their bodies. Embodied emotion theorists propose that this connection is not purely linguistic; perceiving an emotion may require somatosensory and motor re-experiencing. However, it…

Neurons and Cognition · Quantitative Biology 2024-11-15 Marianne C. Reddan , Luke Chang , Philip Kragel , Tor D. Wager

Identifying the underlying reason for a failing dynamic process or otherwise anomalous observation is a fundamental challenge, yet has numerous industrial applications. Identifying the failure-causing sub-system using causal inference, one…

Machine Learning · Computer Science 2024-06-13 Juliane Weilbach , Sebastian Gerwinn , Karim Barsim , Martin Fränzle

In daily life, we encounter diverse external stimuli, such as images, sounds, and videos. As research in multimodal stimuli and neuroscience advances, fMRI-based brain decoding has become a key tool for understanding brain perception and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Pengyu Liu , Guohua Dong , Dan Guo , Kun Li , Fengling Li , Xun Yang , Meng Wang , Xiaomin Ying

The Causal Roadmap outlines a systematic approach to asking and answering questions of cause-and-effect: define the quantity of interest, evaluate needed assumptions, conduct statistical estimation, and carefully interpret results. To…

Methodology · Statistics 2024-05-30 Nerissa Nance , Maya L. Petersen , Mark van der Laan , Laura B. Balzer

We present a domain-general account of causation that applies to settings in which macro-level causal relations between two systems are of interest, but the relevant causal features are poorly understood and have to be aggregated from vast…

Machine Learning · Statistics 2015-12-29 Krzysztof Chalupka , Pietro Perona , Frederick Eberhardt

Causal inference methods for observational data are increasingly recognized as a valuable complement to randomized clinical trials (RCTs). They can, under strong assumptions, emulate RCTs or help refine their focus. Our approach to causal…

Methodology · Statistics 2024-08-14 Carlo Berzuini , Davide Luciani , Hiren C. Patel

Separation of the sources and analysis of their connectivity have been an important topic in EEG/MEG analysis. To solve this problem in an automatic manner, we propose a two-layer model, in which the sources are conditionally uncorrelated…

Machine Learning · Computer Science 2012-03-19 Kun Zhang , Aapo Hyvarinen

Bidirectional causal relationships arising from mutual interactions between variables are commonly observed within biomedical, econometrical, and social science contexts. When such relationships are further complicated by unobserved…

Methodology · Statistics 2026-01-27 Yafang Deng , Kang Shuai , Shanshan Luo

Performance monitoring, anomaly detection, and root-cause analysis in complex cyber-physical systems (CPSs) are often highly intractable due to widely diverse operational modes, disparate data types, and complex fault propagation…

Machine Learning · Statistics 2018-06-01 Chao Liu , Kin Gwn Lore , Zhanhong Jiang , Soumik Sarkar

Many fMRI analyses examine functional connectivity, or statistical dependencies among remote brain regions. Yet popular methods for studying whole-brain functional connectivity often yield results that are difficult to interpret. Factor…

Methodology · Statistics 2024-09-24 Kyle Stanley , Nicole Lazar , Matthew Reimherr

We localize the sources of brain activity of children with epilepsy based on EEG recordings acquired during a visual discrimination working memory task. For the numerical solution of the inverse problem, with the aid of age-specific MRI…

Neurons and Cognition · Quantitative Biology 2023-03-16 Evangelos Galaris , Ioannis Gallos , Ivan Myatchin , Lieven Lagae , Constantinos Siettos

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

Normative modeling enables individualized characterization of structural brain deviations by evaluating subjects against a reference population rather than a group average. Most existing implementations treat brain regions independently and…

Methodology · Statistics 2026-05-19 J. T. Korley

A structural vector autoregressive (SVAR) process is a linear causal model for variables that evolve over a discrete set of time points and between which there may be lagged and instantaneous effects. The qualitative causal structure of an…

Statistics Theory · Mathematics 2024-08-19 Nicolas-Domenic Reiter , Jonas Wahl , Andreas Gerhardus , Jakob Runge

Bivariate structural causal models (SCM) are often used to infer causal direction by examining their goodness-of-fit under restricted model classes. In this paper, we describe a parametrization of bivariate SCMs in terms of a causal…

Machine Learning · Statistics 2025-06-11 Johnny Xi , Hugh Dance , Peter Orbanz , Benjamin Bloem-Reddy

We consider the challenges in extracting stimulus-related neural dynamics from other intrinsic processes and noise in naturalistic functional magnetic resonance imaging (fMRI). Most studies rely on inter-subject correlations (ISC) of…

Neurons and Cognition · Quantitative Biology 2021-02-23 Chee-Ming Ting , Jeremy I. Skipper , Steven L. Small , Hernando Ombao

Naturalistic fMRI characterizes the brain as a dynamic predictive engine driven by continuous sensory streams. However, modeling the causal forward evolution in realistic neural simulation is impeded by the timescale mismatch between…

Neurons and Cognition · Quantitative Biology 2026-02-05 Xuanhua Yin , Runkai Zhao , Lina Yao , Weidong Cai

Functional Magnetic Resonance Images acquired during resting-state provide information about the functional organization of the brain through measuring correlations between brain areas. Independent components analysis is the reference…

Neurons and Cognition · Quantitative Biology 2014-12-15 Alexandre Abraham , Elvis Dohmatob , Bertrand Thirion , Dimitris Samaras , Gael Varoquaux