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Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research…

Human-Computer Interaction · Computer Science 2025-06-18 Samuel Schmidgall , Yusheng Su , Ze Wang , Ximeng Sun , Jialian Wu , Xiaodong Yu , Jiang Liu , Michael Moor , Zicheng Liu , Emad Barsoum

Open-domain dialogue systems have seen remarkable advancements with the development of large language models (LLMs). Nonetheless, most existing dialogue systems predominantly focus on brief single-session interactions, neglecting the…

Computation and Language · Computer Science 2025-02-14 Hao Li , Chenghao Yang , An Zhang , Yang Deng , Xiang Wang , Tat-Seng Chua

LLM-based multi-agent systems have demonstrated remarkable performance on complex tasks through collaborative reasoning. However, these systems tend to rapidly accumulate extremely long conversation histories during interaction. As…

Artificial Intelligence · Computer Science 2026-05-29 Hongxiang Zhang , Yuan Tian , Tianyi Zhang

In this paper, we propose a novel factored agent architecture designed to overcome the limitations of traditional single-agent systems in agentic AI. Our approach decomposes the agent into two specialized components: (1) a large language…

Artificial Intelligence · Computer Science 2025-04-03 Nicholas Roth , Christopher Hidey , Lucas Spangher , William F. Arnold , Chang Ye , Nick Masiewicki , Jinoo Baek , Peter Grabowski , Eugene Ie

Large Language Models (LLMs) have demonstrated remarkable capabilities in solving various tasks, yet they often struggle with comprehensively addressing complex and vague problems. Existing approaches, including multi-agent LLM systems,…

Multiagent Systems · Computer Science 2024-07-11 Sumedh Rasal , E. J. Hauer

In this paper, we introduce a novel learning paradigm for Adaptive Large Language Model (LLM) agents that eliminates the need for fine-tuning the underlying LLMs. Existing approaches are often either rigid, relying on static, handcrafted…

Machine Learning · Computer Science 2025-08-26 Huichi Zhou , Yihang Chen , Siyuan Guo , Xue Yan , Kin Hei Lee , Zihan Wang , Ka Yiu Lee , Guchun Zhang , Kun Shao , Linyi Yang , Jun Wang

Background: The surge in single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and…

Genomics · Quantitative Biology 2026-03-17 Yang Liu , Lu Zhou , Xiawei Du , Ruikun He , Xuguang Zhang , Rongbo Shen , Yixue Li

LLM-based intelligent agents face significant deployment challenges, particularly related to resource management. Allowing unrestricted access to LLM or tool resources can lead to inefficient or even potentially harmful resource allocation…

Operating Systems · Computer Science 2025-08-13 Kai Mei , Xi Zhu , Wujiang Xu , Wenyue Hua , Mingyu Jin , Zelong Li , Shuyuan Xu , Ruosong Ye , Yingqiang Ge , Yongfeng Zhang

As LLMs are increasingly deployed as agents, agentic reasoning - the ability to combine tool use, especially search, and reasoning - becomes a critical skill. However, it is hard to disentangle agentic reasoning when evaluated in complex…

Artificial Intelligence · Computer Science 2025-10-03 Hanlin Zhu , Tianyu Guo , Song Mei , Stuart Russell , Nikhil Ghosh , Alberto Bietti , Jiantao Jiao

Existing LLM-enabled multi-agent frameworks are predominantly limited to digital or simulated environments and confined to narrowly focused knowledge domain, constraining their applicability to complex engineering tasks that require the…

Large Language Model (LLM) agents are increasingly used in real-world products, where personalized and context-aware user interactions are essential. A central enabler of such capabilities is the agent's long-term semantic memory system,…

Information Retrieval · Computer Science 2026-05-27 Zhentao Xu , Shangjin Zhang , Emir Poyraz , Yvonne Li , Ye Jin , Xie Lu , Xiaoyang Gu , Karthik Ramgopal , Praveen Kumar Bodigutla , Xiaofeng Wang

Open-sourced Large Language Models (LLMs) have achieved great success in various NLP tasks, however, they are still far inferior to API-based models when acting as agents. How to integrate agent ability into general LLMs becomes a crucial…

Computation and Language · Computer Science 2024-03-20 Zehui Chen , Kuikun Liu , Qiuchen Wang , Wenwei Zhang , Jiangning Liu , Dahua Lin , Kai Chen , Feng Zhao

Large Language Models (LLMs) have opened transformative possibilities for human-robot collaboration. However, enabling real-time collaboration requires both low latency and robust reasoning, and most LLMs suffer from high latency. To…

Artificial Intelligence · Computer Science 2026-01-27 Shipeng Liu , Boshen Zhang , Zhehui Huang

Large language model (LLM)-based agents that reason, plan, and act through tools, memory, and structured interaction are emerging as a promising paradigm for automating complex workflows. Recent systems such as OpenClaw and Claude Code…

Information Retrieval · Computer Science 2026-05-27 Yingli Zhou , Wang Shu , Yaodong Su , Wenchuan Du , Yixiang Fang , Xuemin Lin

Multi-agent systems (MAS) enable complex reasoning by coordinating multiple agents, but often incur high inference latency due to multi-step execution and repeated model invocations, severely limiting their scalability and usability in…

Multiagent Systems · Computer Science 2026-01-16 Xi Shi , Mengxin Zheng , Qian Lou

Current LLM agents are proficient at calling isolated APIs but struggle with the "last mile" of commercial software automation. In real-world scenarios, tools are not independent; they are atomic, interdependent, and prone to environmental…

Artificial Intelligence · Computer Science 2026-05-21 Yuanyang Li , Xue Yang , Longyue Wang , Weihua Luo , Hongyang Chen

Foundation models are becoming valuable tools in medicine. Yet despite their promise, the best way to leverage Large Language Models (LLMs) in complex medical tasks remains an open question. We introduce a novel multi-agent framework, named…

Computation and Language · Computer Science 2024-10-31 Yubin Kim , Chanwoo Park , Hyewon Jeong , Yik Siu Chan , Xuhai Xu , Daniel McDuff , Hyeonhoon Lee , Marzyeh Ghassemi , Cynthia Breazeal , Hae Won Park

Existing LLMs exhibit remarkable performance on various NLP tasks, but still struggle with complex real-world tasks, even equipped with advanced strategies like CoT and ReAct. In this work, we propose the CoAct framework, which transfers…

Computation and Language · Computer Science 2024-06-21 Xinming Hou , Mingming Yang , Wenxiang Jiao , Xing Wang , Zhaopeng Tu , Wayne Xin Zhao

The rise of AI-native Low-Code/No-Code (LCNC) platforms enables autonomous agents capable of executing complex, long-duration business processes. However, a fundamental challenge remains: memory management. As agents operate over extended…

Artificial Intelligence · Computer Science 2025-10-01 Jiexi Xu

Modern language agents must operate over long-horizon, multi-turn histories, yet deploying such agents with Small Language Models (SLMs) remains fundamentally difficult. Full-context prompting causes context overflow, flat retrieval exposes…

Multiagent Systems · Computer Science 2026-05-06 Jiayi Chen , Yingcong Li , Guiling Wang