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In application domains such as healthcare, we want accurate predictive models that are also causally interpretable. In pursuit of such models, we propose a causal regularizer to steer predictive models towards causally-interpretable…

Machine Learning · Computer Science 2017-02-24 Mohammad Taha Bahadori , Krzysztof Chalupka , Edward Choi , Robert Chen , Walter F. Stewart , Jimeng Sun

Most of previous machine learning algorithms are proposed based on the i.i.d. hypothesis. However, this ideal assumption is often violated in real applications, where selection bias may arise between training and testing process. Moreover,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-24 Zheyan Shen , Peng Cui , Kun Kuang , Bo Li , Peixuan Chen

Reinforcement Learning (RL) agents in the real world must satisfy safety constraints in addition to maximizing a reward objective. Model-based RL algorithms hold promise for reducing unsafe real-world actions: they may synthesize policies…

Machine Learning · Computer Science 2021-12-16 Yecheng Jason Ma , Andrew Shen , Osbert Bastani , Dinesh Jayaraman

Recent work has raised concerns on the risk of spurious correlations and unintended biases in statistical machine learning models that threaten model robustness and fairness. In this paper, we propose a simple and intuitive regularization…

Machine Learning · Computer Science 2021-10-05 Zhao Wang , Kai Shu , Aron Culotta

Regularization improves generalization of supervised models to out-of-sample data. Prior works have shown that prediction in the causal direction (effect from cause) results in lower testing error than the anti-causal direction. However,…

Machine Learning · Computer Science 2020-09-29 Trent Kyono , Yao Zhang , Mihaela van der Schaar

A predictive model makes outcome predictions based on some given features, i.e., it estimates the conditional probability of the outcome given a feature vector. In general, a predictive model cannot estimate the causal effect of a feature…

Machine Learning · Computer Science 2023-04-11 Jiuyong Li , Lin Liu , Ziqi Xu , Ha Xuan Tran , Thuc Duy Le , Jixue Liu

Prediction models need reliable predictive performance as they inform clinical decisions, aiding in diagnosis, prognosis, and treatment planning. The predictive performance of these models is typically assessed through discrimination and…

Methodology · Statistics 2025-04-25 Wouter A. C. van Amsterdam

Algorithmic recourse provides individuals who receive undesirable outcomes from machine learning systems with minimum-cost improvements to achieve a desirable outcome. However, machine learning models often get updated, so the recourse may…

Machine Learning · Computer Science 2026-04-28 Kshitij Kayastha , Vasilis Gkatzelis , Shahin Jabbari

High-dimensional compositional data are prevalent in many applications. The simplex constraint poses intrinsic challenges to inferring the conditional dependence relationships among the components forming a composition, as encoded by a…

Methodology · Statistics 2024-03-25 Shucong Zhang , Huiyuan Wang , Wei Lin

Most algorithms in classical and contemporary machine learning focus on correlation-based dependence between features to drive performance. Although success has been observed in many relevant problems, these algorithms fail when the…

Machine Learning · Computer Science 2021-10-26 Moritz Willig , Matej Zečević , Devendra Singh Dhami , Kristian Kersting

Uncertainty quantification of causal effects is crucial for safety-critical applications such as personalized medicine. A powerful approach for this is conformal prediction, which has several practical benefits due to model-agnostic…

Machine Learning · Computer Science 2026-02-04 Maresa Schröder , Dennis Frauen , Jonas Schweisthal , Konstantin Heß , Valentyn Melnychuk , Stefan Feuerriegel

Causal inference and model interpretability research are gaining increasing attention, especially in the domains of healthcare and bioinformatics. Despite recent successes in this field, decorrelating features under nonlinear environments…

Machine Learning · Computer Science 2022-09-30 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline Thirukumaran , Addisu Mesfin , Jiebo Luo

Estimating the Conditional Average Treatment Effect (CATE) is often constrained by the high cost of obtaining outcome measurements, making active learning essential. However, conventional active learning strategies suffer from a fundamental…

Machine Learning · Statistics 2025-09-29 Erdun Gao , Jake Fawkes , Dino Sejdinovic

Understanding the dose-response relation between a continuous treatment and the outcome for an individual can greatly drive decision-making, particularly in areas like personalized drug dosing and personalized healthcare interventions.…

Machine Learning · Computer Science 2026-01-07 Jarne Verhaeghe , Jef Jonkers , Sofie Van Hoecke

In text classification tasks, models often rely on spurious correlations for predictions, incorrectly associating irrelevant features with the target labels. This issue limits the robustness and generalization of models, especially when…

Machine Learning · Computer Science 2025-02-04 Yuqing Zhou , Ziwei Zhu

The deployment of multimodal models in high-stakes domains, such as self-driving vehicles and medical diagnostics, demands not only strong predictive performance but also reliable mechanisms for detecting failures. In this work, we address…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Moru Liu , Hao Dong , Olga Fink , Mario Trapp

Causal inference is a critical task across fields such as healthcare, economics, and the social sciences. While recent advances in machine learning, especially those based on the deep-learning architectures, have shown potential in…

Machine Learning · Statistics 2024-12-30 Manqing Liu , David R. Bellamy , Andrew L. Beam

Machine Learning explainability techniques have been proposed as a means of `explaining' or interrogating a model in order to understand why a particular decision or prediction has been made. Such an ability is especially important at a…

Machine Learning · Statistics 2022-02-28 Matthew J. Vowels

Causal structure discovery from observational data is fundamental to the causal understanding of autonomous systems such as medical decision support systems, advertising campaigns and self-driving cars. This is essential to solve well-known…

The conditional average treatment effect (CATE) is widely used in personalized medicine to inform therapeutic decisions. However, state-of-the-art methods for CATE estimation (so-called meta-learners) often perform poorly in the presence of…

Machine Learning · Computer Science 2026-03-12 Valentyn Melnychuk , Dennis Frauen , Jonas Schweisthal , Stefan Feuerriegel
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