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The LUMIR challenge represents an important benchmark for evaluating deformable image registration methods on large-scale neuroimaging data. While the challenge demonstrates that modern deep learning methods achieve competitive accuracy on…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Rohit Jena , Pratik Chaudhari , James C. Gee

Medical image challenges have played a transformative role in advancing the field, catalyzing innovation and establishing new performance benchmarks. Image registration, a foundational task in neuroimaging, has similarly advanced through…

Deep learning based deformable registration methods have become popular in recent years. However, their ability to generalize beyond training data distribution can be poor, significantly hindering their usability. LUMIR brain registration…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Joel Honkamaa , Pekka Marttinen

Deformable image registration remains a central challenge in medical image analysis, particularly under multi-modal scenarios where intensity distributions vary significantly across scans. While deep learning methods provide efficient…

Image and Video Processing · Electrical Eng. & Systems 2026-03-30 Yi Zhang , Yidong Zhao , Qian Tao

Accurate intraoperative image guidance is critical for achieving maximal safe resection in brain tumor surgery, yet neuronavigation systems based on preoperative MRI lose accuracy during the procedure due to brain shift. Aligning…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Reuben Dorent , Laura Rigolo , Colin P. Galvin , Junyu Chen , Mattias P. Heinrich , Aaron Carass , Olivier Colliot , Demian Wassermann , Alexandra Golby , Tina Kapur , William Wells

Unsupervised learning strategy is widely adopted by the deformable registration models due to the lack of ground truth of deformation fields. These models typically depend on the intensity-based similarity loss to obtain the learning…

Image and Video Processing · Electrical Eng. & Systems 2021-12-21 Luyi Han , Haoran Dou , Yunzhi Huang , Pew-Thian Yap

Recent learning-based approaches have made astonishing advances in calibrated medical imaging like computerized tomography (CT), yet they struggle to generalize in uncalibrated modalities -- notably magnetic resonance (MR) imaging, where…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Peirong Liu , Oula Puonti , Xiaoling Hu , Daniel C. Alexander , Juan E. Iglesias

We introduce a strategy for learning image registration without acquired imaging data, producing powerful networks agnostic to contrast introduced by magnetic resonance imaging (MRI). While classical registration methods accurately estimate…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Malte Hoffmann , Benjamin Billot , Douglas N. Greve , Juan Eugenio Iglesias , Bruce Fischl , Adrian V. Dalca

In clinical practice, well-aligned multi-modal images, such as Magnetic Resonance (MR) and Computed Tomography (CT), together can provide complementary information for image-guided therapies. Multi-modal image registration is essential for…

Computer Vision and Pattern Recognition · Computer Science 2022-04-29 Zekang Chen , Jia Wei , Rui Li

In this paper, we summarize the methods and experimental results we proposed for Task 2 in the learn2reg 2024 Challenge. This task focuses on unsupervised registration of anatomical structures in brain MRI images between different patients.…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Yuxi Zhang , Xiang Chen , Jiazheng Wang , Min Liu , Yaonan Wang , Dongdong Liu , Renjiu Hu , Hang Zhang

Establishing voxelwise semantic correspondence across distinct imaging modalities is a foundational yet formidable computer vision task. Current multi-modality registration techniques maximize hand-crafted inter-domain similarity functions,…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Neel Dey , Jo Schlemper , Seyed Sadegh Mohseni Salehi , Bo Zhou , Guido Gerig , Michal Sofka

Registration of brain scans with pathologies is difficult, yet important research area. The importance of this task motivated researchers to organize the BraTS-Reg challenge, jointly with IEEE ISBI 2022 and MICCAI 2022 conferences. The…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Marek Wodzinski , Artur Jurgas , Niccolo Marini , Manfredo Atzori , Henning Muller

Medical image registration is a fundamental task in medical image analysis, enabling the alignment of images from different modalities or time points. However, intensity inconsistencies and nonlinear tissue deformations pose significant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Eytan Kats , Christoph Grossbroehmer , Ziad Al-Haj Hemidi , Fenja Falta , Wiebke Heyer , Mattias P. Heinrich

Analysis of longitudinal changes in imaging studies often involves both segmentation of structures of interest and registration of multiple timeframes. The accuracy of such analysis could benefit from a tailored framework that jointly…

Computer Vision and Pattern Recognition · Computer Science 2021-02-25 Bo Li , Wiro J. Niessen , Stefan Klein , M. Arfan Ikram , Meike W. Vernooij , Esther E. Bron

Rigid registration aims to determine the translations and rotations necessary to align features in a pair of images. While recent machine learning methods have become state-of-the-art for linear and deformable registration across subjects,…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Jingru Fu , Adrian V. Dalca , Bruce Fischl , Rodrigo Moreno , Malte Hoffmann

The recent application of deep learning technologies in medical image registration has exponentially decreased the registration time and gradually increased registration accuracy when compared to their traditional counterparts. Most of the…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Abdullah Nazib , Clinton Fookes , Olivier Salvado , Dimitri Perrin

Brain imaging classification is commonly approached from two perspectives: modeling the full image volume to capture global anatomical context, or constructing ROI-based graphs to encode localized and topological interactions. Although both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Wei Liang , Lifang He

Deep Learning in Image Registration (DLIR) methods have been tremendously successful in image registration due to their speed and ability to incorporate weak label supervision at training time. However, existing DLIR methods forego many of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Rohit Jena , Pratik Chaudhari , James C. Gee

Multi-modal image registration plays a critical role in precision medicine but faces challenges from non-linear intensity relationships and local optima. While deep learning models enable rapid inference, they often suffer from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-14 Boya Wang , Ruizhe Li , Chao Chen , Xin Chen

Magnetic Resonance (MR) imaging allows the acquisition of images with different contrast properties depending on the acquisition protocol and the magnetic properties of tissues. Many MR brain image processing techniques, such as tissue…

Computer Vision and Pattern Recognition · Computer Science 2018-04-18 Samuel Remedios , Dzung L. Pham , John A. Butman , Snehashis Roy
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