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Retrieval-augmented generation (RAG) systems have become widely used for enhancing large language model capabilities, but they introduce significant security vulnerabilities through prompt injection attacks. We present a comprehensive…

Cryptography and Security · Computer Science 2025-11-21 Badrinath Ramakrishnan , Akshaya Balaji

Although LLM-based agents, powered by Large Language Models (LLMs), can use external tools and memory mechanisms to solve complex real-world tasks, they may also introduce critical security vulnerabilities. However, the existing literature…

Cryptography and Security · Computer Science 2025-06-02 Hanrong Zhang , Jingyuan Huang , Kai Mei , Yifei Yao , Zhenting Wang , Chenlu Zhan , Hongwei Wang , Yongfeng Zhang

Millions of individuals' well-being are challenged by the harms of substance use. Harm reduction as a public health strategy is designed to improve their health outcomes and reduce safety risks. Some large language models (LLMs) have…

Computation and Language · Computer Science 2025-07-30 Kaixuan Wang , Chenxin Diao , Jason T. Jacques , Zhongliang Guo , Shuai Zhao

While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows.…

Recent work has embodied LLMs as agents, allowing them to access tools, perform actions, and interact with external content (e.g., emails or websites). However, external content introduces the risk of indirect prompt injection (IPI)…

Computation and Language · Computer Science 2024-08-06 Qiusi Zhan , Zhixiang Liang , Zifan Ying , Daniel Kang

Recent advances in Retrieval-Augmented Generation (RAG) have enabled large language models (LLMs) to ground outputs in clinical evidence. However, connecting LLMs with external databases introduces the risk of contextual leakage: a subtle…

Computation and Language · Computer Science 2026-03-17 Shaowei Guan , Yu Zhai , Hin Chi Kwok , Jiawei Du , Xinyu Feng , Jing Li , Harry Qin , Vivian Hui

Recent studies demonstrate that Large Language Models (LLMs) are vulnerable to different prompt-based attacks, generating harmful content or sensitive information. Both closed-source and open-source LLMs are underinvestigated for these…

Cryptography and Security · Computer Science 2025-05-21 Jiawen Wang , Pritha Gupta , Ivan Habernal , Eyke Hüllermeier

Application designers have moved to integrate large language models (LLMs) into their products. However, many LLM-integrated applications are vulnerable to prompt injections. While attempts have been made to address this problem by building…

Cryptography and Security · Computer Science 2025-04-15 Dennis Jacob , Hend Alzahrani , Zhanhao Hu , Basel Alomair , David Wagner

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of applications. However, their practical deployment is often hindered by issues such as outdated knowledge and the tendency to generate…

Cryptography and Security · Computer Science 2026-03-27 Haozhen Wang , Haoyue Liu , Jionghao Zhu , Zhichao Wang , Yongxin Guo , Xiaoying Tang

Large language models (LLMs) are increasingly deployed in medical contexts, raising critical concerns about safety, alignment, and susceptibility to adversarial manipulation. While prior benchmarks assess model refusal capabilities for…

Computation and Language · Computer Science 2025-05-19 Sijia Chen , Xiaomin Li , Mengxue Zhang , Eric Hanchen Jiang , Qingcheng Zeng , Chen-Hsiang Yu

Research on emergency and mass casualty incident (MCI) triage has been limited by the absence of openly usable, reproducible benchmarks. Yet these scenarios demand rapid identification of the patients most in need, where accurate…

Machine Learning · Computer Science 2026-03-31 Joshua Sebastian , Karma Tobden , KMA Solaiman

Large Vision-Language Models (LVLMs) augmented with Retrieval-Augmented Generation (RAG) are increasingly employed in medical AI to enhance factual grounding through external clinical image-text retrieval. However, this reliance creates a…

Machine Learning · Computer Science 2026-01-06 Kaiwen Zuo , Zelin Liu , Raman Dutt , Ziyang Wang , Zhongtian Sun , Fan Mo , Pietro Liò

Large Language Models (LLMs) are increasingly used in a variety of important applications, yet their safety and reliability remain as major concerns. Various adversarial and jailbreak attacks have been proposed to bypass the safety…

Computation and Language · Computer Science 2024-10-18 Leon Zhou , Junfeng Yang , Chengzhi Mao

Prompt injection attacks pose a pervasive threat to the security of Large Language Models (LLMs). State-of-the-art prevention-based defenses typically rely on fine-tuning an LLM to enhance its security, but they achieve limited…

Cryptography and Security · Computer Science 2025-11-17 Yupei Liu , Yanting Wang , Yuqi Jia , Jinyuan Jia , Neil Zhenqiang Gong

Large Language Models (LLMs) excel in processing and generating human language, powered by their ability to interpret and follow instructions. However, their capabilities can be exploited through prompt injection attacks. These attacks…

Artificial Intelligence · Computer Science 2024-03-11 Xiaogeng Liu , Zhiyuan Yu , Yizhe Zhang , Ning Zhang , Chaowei Xiao

Large Language Models (LLMs) have seen rapid adoption in recent years, with industries increasingly relying on them to maintain a competitive advantage. These models excel at interpreting user instructions and generating human-like…

Cryptography and Security · Computer Science 2025-09-09 Andrew Yeo , Daeseon Choi

LLM-integrated applications are vulnerable to prompt injection attacks, where an attacker contaminates the input to inject malicious instructions, causing the LLM to follow the attacker's intent instead of the original user's. Existing…

Cryptography and Security · Computer Science 2026-01-27 Wei Zou , Yupei Liu , Yanting Wang , Ying Chen , Neil Gong , Jinyuan Jia

The rapid identification of medical emergencies through digital communication channels remains a critical challenge in modern healthcare delivery, particularly with the increasing prevalence of telemedicine. This paper presents a novel…

Machine Learning · Computer Science 2024-12-24 Ferit Akaybicen , Aaron Cummings , Lota Iwuagwu , Xinyue Zhang , Modupe Adewuyi

As LLM agents transition from digital assistants to physical controllers in autonomous systems and robotics, they face an escalating threat from indirect prompt injection. By embedding adversarial instructions into the results of tool…

Artificial Intelligence · Computer Science 2026-01-09 Qiang Yu , Xinran Cheng , Chuanyi Liu

Large Language Models (LLMs) are vulnerable to prompt injection attacks, and several defenses have recently been proposed, often claiming to mitigate these attacks successfully. However, we argue that existing studies lack a principled…

Cryptography and Security · Computer Science 2025-05-27 Yuqi Jia , Zedian Shao , Yupei Liu , Jinyuan Jia , Dawn Song , Neil Zhenqiang Gong
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