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Mental and cognitive representations are believed to reside on low-dimensional, non-linear manifolds embedded within high-dimensional brain activity. Uncovering these manifolds is key to understanding individual differences in brain…

Machine Learning · Computer Science 2025-05-02 Eloy Geenjaar , Vince Calhoun

Weakly Supervised Anomaly detection (WSAD) in brain MRI scans is an important challenge useful to obtain quick and accurate detection of brain anomalies when precise pixel-level anomaly annotations are unavailable and only weak labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Bheeshm Sharma , Karthikeyan Jaganathan , Balamurugan Palaniappan

Effective multivariate time series forecasting often benefits from accurately modeling complex inter-variable dependencies. However, existing attention- or graph-based methods face three key issues: (a) strong temporal self-dependencies are…

Machine Learning · Computer Science 2025-12-19 Feng Xiong , Zongxia Xie , Yanru Sun , Haoyu Wang , Jianhong Lin

Understanding the relationships between different properties of data, such as whether a connectome or genome has information about disease status, is becoming increasingly important in modern biological datasets. While existing approaches…

Machine Learning · Statistics 2024-06-27 Joshua T. Vogelstein , Eric Bridgeford , Qing Wang , Carey E. Priebe , Mauro Maggioni , Cencheng Shen

Understanding how the human brain instantiates distinct emotional states is a key challenge in affective neuroscience. While network-based approaches have advanced emotion processing research,they remain largely descriptive,leaving the…

Neurons and Cognition · Quantitative Biology 2026-03-31 Barry Djibrina , Jiajia Li

Functional connectivity network (FCN) data from functional magnetic resonance imaging (fMRI) is increasingly used for the diagnoses of brain disorders. However, state-of-the-art studies used to build the FCN using a single brain…

Image and Video Processing · Electrical Eng. & Systems 2022-09-26 Mianxin Liu , Han Zhang , Feng Shi , Dinggang Shen

Data-driven graph learning models a network by determining the strength of connections between its nodes. The data refers to a graph signal which associates a value with each graph node. Existing graph learning methods either use simplified…

Machine Learning · Computer Science 2020-11-05 Nafiseh Ghoroghchian , David M. Groppe , Roman Genov , Taufik A. Valiante , Stark C. Draper

This paper focuses on the analysis of spatially correlated functional data. The between-curve correlation is modeled by correlating functional principal component scores of the functional data. We propose a Spatial Principal Analysis by…

Statistics Theory · Mathematics 2014-11-19 Chong Liu , Surajit Ray , Giles Hooker

The goal of the present study is to identify autism using machine learning techniques and resting-state brain imaging data, leveraging the temporal variability of the functional connections (FC) as the only information. We estimated and…

Neurons and Cognition · Quantitative Biology 2017-12-22 Ravi Tejwani , Adam Liska , Hongyuan You , Jenna Reinen , Payel Das

Mental disorders such as Autism Spectrum Disorders (ASD) are heterogeneous disorders that are notoriously difficult to diagnose, especially in children. The current psychiatric diagnostic process is based purely on the behavioural…

Machine Learning · Computer Science 2019-04-17 Taban Eslami , Vahid Mirjalili , Alvis Fong , Angela Laird , Fahad Saeed

Modern neuroimaging techniques provide us with unique views on brain structure and function; i.e., how the brain is wired, and where and when activity takes place. Data acquired using these techniques can be analyzed in terms of its network…

Image and Video Processing · Electrical Eng. & Systems 2018-01-31 Weiyu Huang , Thomas A. W. Bolton , John D. Medaglia , Danielle S. Bassett , Alejandro Ribeiro , Dimitri Van De Ville

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

Many existing methods that use functional magnetic resonance imaging (fMRI) classify brain disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), often overlook the integration of spatial and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-08 Wenhao Dong , Yueyang Li , Weiming Zeng , Lei Chen , Hongjie Yan , Wai Ting Siok , Nizhuan Wang

Autism Spectrum Condition (ASC) is a neurodevelopmental condition characterized by impairments in communication, social interaction and restricted or repetitive behaviors. Extensive research has been conducted to identify distinctions…

Quantitative Methods · Quantitative Biology 2024-05-22 F. J. Alcaide , I. A. Illan , J. Ramirez , J. M. Gorriz

Resting-state functional MRI (rs-fMRI) is increasingly employed in multi-site research to aid neurological disorder analysis. Existing studies usually suffer from significant cross-site/domain data heterogeneity caused by site effects such…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Yuqi Fang , Jinjian Wu , Qianqian Wang , Shijun Qiu , Andrea Bozoki , Huaicheng Yan , Mingxia Liu

We consider the problem of extracting features from passive, multi-channel electroencephalogram (EEG) devices for downstream inference tasks related to high-level mental states such as stress and cognitive load. Our proposed method…

Signal Processing · Electrical Eng. & Systems 2022-03-02 Guodong Chen , Hayden S. Helm , Kate Lytvynets , Weiwei Yang , Carey E. Priebe

Accounting for inter-individual variability in brain function is key to precision medicine. Here, by considering functional inter-individual variability as meaningful data rather than noise, we introduce VarCoNet, an enhanced…

Neural and Evolutionary Computing · Computer Science 2025-10-06 Charalampos Lamprou , Aamna Alshehhi , Leontios J. Hadjileontiadis , Mohamed L. Seghier

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by varied social cognitive challenges and repetitive behavioral patterns. Identifying reliable brain imaging-based biomarkers for ASD has been a persistent…

Machine Learning · Computer Science 2024-09-30 Mehul Arora , Chirag Shantilal Jain , Lalith Bharadwaj Baru , Kamalaker Dadi , Bapi Raju Surampudi