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Diffusion MRI imaging and tractography algorithms have enabled the mapping of the macro-scale connectome of the entire brain. At the functional level, probably the simplest way to study the dynamics of macro-scale brain activity is to…

Neurons and Cognition · Quantitative Biology 2022-07-19 Qihang Yao , Manoj Chandrasekaran , Constantine Dovrolis

The human brain has a complex, intricate functional architecture. While many studies primarily emphasize pairwise interactions, delving into high-order associations is crucial for a comprehensive understanding of how functional brain…

Neurons and Cognition · Quantitative Biology 2023-10-30 Qiang Li , Vince D. Calhoun , Adithya Ram Ballem , Shujian Yu , Jesus Malo , Armin Iraji

Major depressive disorder (MDD) is a common neuropsychiatric condition whose accurate diagnosis from resting-state functional magnetic resonance imaging (rs-fMRI) remains difficult. Dynamic functional connectivity (DFC) captures…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Muhammad Asif Hasan , Yanming Zhu , Xuefei Yin , Alan Wee-Chung Liew

The distributed nature of the neural substrate, and the difficulty of establishing necessity from correlative data, combine to render the mapping of brain function a far harder task than it seems. Methods capable of combining connective…

The global functional brain network (graph) is more suitable for characterizing brain states than local analysis of the connectivity of brain regions. Therefore, graph-theoretic approaches are the natural methods to study the brain.…

Analysis of brain connectivity is important for understanding how information is processed by the brain. We propose a novel Bayesian vector autoregression (VAR) hierarchical model for analyzing brain connectivity in a resting-state fMRI…

Applications · Statistics 2021-12-09 Bertil Wegmann , Anders Lundquist , Anders Eklund , Mattias Villani

This article introduces a predictor-dependent joint modeling framework for network data obtained from multiple subjects over a shared set of nodes with spatial co-ordinates and spatially correlated nodal attributes. The framework is highly…

Emerging brain network studies suggest that interactions between various distributed neuronal populations may be characterized by an organized complex topological structure. Many brain diseases are associated with altered topological…

Neurons and Cognition · Quantitative Biology 2016-03-24 Shuo Chen , F. DuBois Bowman , Yishi Xing

Several brain disorders can be detected by observing alterations in the brain's structural and functional connectivities. Neurological findings suggest that early diagnosis of brain disorders, such as mild cognitive impairment (MCI), can…

Neurons and Cognition · Quantitative Biology 2021-10-22 Alpay Tekin , Ahmed Nebli , Islem Rekik

Statistical techniques are needed to analyse data structures with complex dependencies such that clinically useful information can be extracted. Individual-specific networks, which capture dependencies in complex biological systems, are…

Methodology · Statistics 2023-08-30 Mariella Gregorich , Sean L. Simpson , Georg Heinze

This study integrates causal inference, graph analysis, temporal complexity measures, and machine learning to examine whether individual symptom trajectories can reveal meaningful diagnostic patterns. Testing on a longitudinal dataset of…

Applications · Statistics 2025-07-22 Eleonora Vitanza , Pietro DeLellis , Chiara Mocenni , Manuel Ruiz Marin

We introduce Permutation and Structured Perturbation Inference (PSPI), a new problem formulation that abstracts many graph matching tasks that arise in systems biology. PSPI can be viewed as a robust formulation of the permutation inference…

Artificial Intelligence · Computer Science 2021-04-05 Raghvendra Mall , Shameem A. Parambath , Han Yufei , Ting Yu , Sanjay Chawla

Autism spectrum disorder (ASD) is one of the major developmental disorders affecting children. Recently, it has been hypothesized that ASD is associated with atypical brain connectivities. A substantial body of researches use Pearson's…

Neurons and Cognition · Quantitative Biology 2019-03-06 Biwei Huang , Kun Zhang , Ruben Sanchez-Romero , Joseph Ramsey , Madelyn Glymour , Clark Glymour

Psychiatric disorders involve complex neural activity changes, with functional magnetic resonance imaging (fMRI) data serving as key diagnostic evidence. However, data scarcity and the diverse nature of fMRI information pose significant…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Mujie Liu , Mengchu Zhu , Qichao Dong , Ting Dang , Jiangang Ma , Jing Ren , Feng Xia

The primary goal of this paper is to develop a method that quantifies how activity in one brain region can explain future activity in another region. Here, we propose the mixed effects spectral vector-autoregressive (ME-SpecVar) model to…

Applications · Statistics 2022-10-07 Anastasiia Malinovskaia

Divergent brain connectivity is thought to underlie the behavioral and cognitive symptoms observed in many neurodevelopmental disorders. Quantifying divergence from neurotypical connectivity patterns offers a promising pathway to inform…

Neurons and Cognition · Quantitative Biology 2024-11-19 Rui Sherry Shen , Yusuf Osmanlıoğlu , Drew Parker , Darien Aunapu , Benjamin E. Yerys , Birkan Tunç , Ragini Verma

Coherence is a widely used measure to assess linear relationships between time series. However, it fails to capture nonlinear dependencies. To overcome this limitation, this paper introduces the notion of residual spectral density as a…

Statistics Theory · Mathematics 2024-05-21 Yuichi Goto , Xuze Zhang , Benjamin Kedem , Shuo Chen

Recent analyses combining advanced theoretical techniques and high-quality data from thousands of simultaneously recorded neurons provide strong support for the hypothesis that neural dynamics operate near the edge of instability across…

Neurons and Cognition · Quantitative Biology 2024-03-25 Rubén Calvo , Carles Martorell , Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for…

Image and Video Processing · Electrical Eng. & Systems 2020-08-06 Sarah Itani , Dorina Thanou

Electroencephalograms (EEG) are noninvasive measurement signals of electrical neuronal activity in the brain. One of the current major statistical challenges is formally measuring functional dependency between those complex signals. This…

Methodology · Statistics 2021-05-14 Marco Antonio Pinto-Orellana , Peyman Mirtaheri , Hugo L. Hammer , Hernando Ombao