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We propose an online false discovery rate (FDR) controlling method based on conditional local FDR (LIS), designed for infectious disease datasets that are discrete and exhibit complex dependencies. Unlike existing online FDR methods, which…

Methodology · Statistics 2026-02-23 Seohwa Hwang , Junyong Park

Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing $n$ hypotheses when test statistics are dependent. In this paper we…

Statistics Theory · Mathematics 2007-10-18 Helmut Finner , Thorsten Dickhaus , Markus Roters

This paper extends the theory of false discovery rates (FDR) pioneered by Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 57 (1995) 289-300]. We develop a framework in which the False Discovery Proportion (FDP)--the number of false…

Statistics Theory · Mathematics 2007-06-13 Christopher Genovese , Larry Wasserman

This paper investigates sequential change-point detection in reconfigurable sensor networks. In this problem, data from multiple sensors are observed sequentially. Each sensor can have a unique change point, and the data distribution…

Methodology · Statistics 2025-04-10 Seungwon Lee , Yunxiao Chen , Xiaoou Li

Model-X knockoffs is a flexible wrapper method for high-dimensional regression algorithms, which provides guaranteed control of the false discovery rate (FDR). Due to the randomness inherent to the method, different runs of model-X…

Methodology · Statistics 2023-09-01 Zhimei Ren , Rina Foygel Barber

MaxT is a highly popular resampling-based multiple testing procedure, which controls the Familywise Error Rate (FWER) and is powerful under dependence. This paper generalizes maxT to what we term ``multi-resolution'' False Discovery…

Methodology · Statistics 2026-05-05 Jesse Hemerik

Inequalities are key tools to prove FDR control of a multiple test. The present paper studies upper and lower bounds for the FDR under various dependence structures of p-values, namely independence, reverse martingale dependence and…

Statistics Theory · Mathematics 2015-02-18 Philipp Heesen , Arnold Janssen

Bayesian networks can represent directed gene regulations and therefore are favored over co-expression networks. However, hardly any Bayesian network study concerns the false discovery control (FDC) of network edges, leading to low…

Methodology · Statistics 2018-03-29 Lingfei Wang , Tom Michoel

When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate (FDR) assume that all p-values are available at the time point of test…

Methodology · Statistics 2021-12-21 Sonja Zehetmayer , Martin Posch , Franz Koenig

Recently, the scheme of model-X knockoffs was proposed as a promising solution to address controlled feature selection under high-dimensional finite-sample settings. However, the procedure of model-X knockoffs depends heavily on the…

Methodology · Statistics 2022-03-10 Xuebin Zhao , Hong Chen , Yingjie Wang , Weifu Li , Tieliang Gong , Yulong Wang , Feng Zheng

There is recent interest in estimating the false discovery rate (FDR) with published p-values. However, there is little formal research that addresses the manner and extent to which the presumed selection, or publication, bias model impacts…

Methodology · Statistics 2026-03-03 Tianyu Cao , Sangyoon Yi , Joshua Habiger

In the online multiple testing problem, p-values corresponding to different null hypotheses are observed one by one, and the decision of whether or not to reject the current hypothesis must be made immediately, after which the next p-value…

Methodology · Statistics 2017-10-03 Aaditya Ramdas , Fanny Yang , Martin J. Wainwright , Michael I. Jordan

Testing composite null hypotheses arises in various applications, such as mediation and replicability analyses. The problem becomes more challenging in high-throughput experiments where tens of thousands of features are examined…

Methodology · Statistics 2025-04-29 Pengfei Lyu , Xianyang Zhang , Hongyuan Cao

We present false discovery rate smoothing, an empirical-Bayes method for exploiting spatial structure in large multiple-testing problems. FDR smoothing automatically finds spatially localized regions of significant test statistics. It then…

Methodology · Statistics 2016-11-15 Wesley Tansey , Oluwasanmi Koyejo , Russell A. Poldrack , James G. Scott

Multiple testing adjustments, such as the Benjamini and Hochberg (1995) step-up procedure for controlling the false discovery rate (FDR), are typically applied to families of tests that control significance level in the classical sense: for…

Methodology · Statistics 2025-05-19 Timothy B. Armstrong

With the rapid growth of crowdsourcing platforms it has become easy and relatively inexpensive to collect a dataset labeled by multiple annotators in a short time. However due to the lack of control over the quality of the annotators, some…

Machine Learning · Statistics 2016-06-17 Qianqian Xu , Jiechao Xiong , Xiaochun Cao , Yuan Yao

Recent tools for interactive data exploration significantly increase the chance that users make false discoveries. The crux is that these tools implicitly allow the user to test a large body of different hypotheses with just a few clicks…

Databases · Computer Science 2016-12-06 Zheguang Zhao , Lorenzo De Stefani , Emanuel Zgraggen , Carsten Binnig , Eli Upfal , Tim Kraska

The local false discovery rate (lfdr) of Efron et al. (2001) enjoys major conceptual and decision-theoretic advantages over the false discovery rate (FDR) as an error criterion in multiple testing, but is only well-defined in Bayesian…

Statistics Theory · Mathematics 2025-02-25 Daniel Xiang , Jake A. Soloff , William Fithian

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one…

Statistics Theory · Mathematics 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

Two major research tasks lie at the heart of high dimensional data analysis: accurate parameter estimation and correct support recovery. The existing literature mostly aims for either the best parameter estimation or the best model…

Statistics Theory · Mathematics 2022-06-24 Qifan Song , Guang Cheng