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Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

When investigating epidemic dynamics through differential models, the parameters needed to understand the phenomenon and to simulate forecast scenarios require a delicate calibration phase, often made even more challenging by the scarcity…

Numerical Analysis · Mathematics 2023-09-11 Giulia Bertaglia , Chuan Lu , Lorenzo Pareschi , Xueyu Zhu

The current clinical diagnosis framework of Alzheimer's disease (AD) involves multiple modalities acquired from multiple diagnosis stages, each with distinct usage and cost. Previous AD diagnosis research has predominantly focused on how to…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 Yuxiao Liu , Mianxin Liu , Yuanwang Zhang , Kaicong Sun , Dinggang Shen

Parkinson's disease (PD) is a debilitating neurological disorder that necessitates precise and early diagnosis for effective patient care. This study aims to develop a diagnostic model capable of achieving both high accuracy and minimizing…

Machine Learning · Computer Science 2024-01-30 Seyedeh Zahra Seyedi Hosseininian , Ahmadreza Tajari , Mohsen Ghalehnoie , Alireza Alfi

Autism spectrum disorder (ASD) has been associated with structural alterations across cortical and subcortical regions. Quantitative neuroimaging enables large-scale analysis of these neuroanatomical patterns. This project used structural…

Neurons and Cognition · Quantitative Biology 2025-12-30 Ashley Chen

Handwriting is significantly affected by neurological disorders (ND) such as Parkinson's disease (PD) and Alzheimer's disease (AD). Prior works have analyzed handwriting tasks using feature-based approaches or computer-vision techniques,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Gabrielle Chavez , Laureano Moro-Velazquez , Ankur Butala , Najim Dehak , Thomas Thebaud

Early and accurate diagnosis of Alzheimer's disease (AD) remains a critical challenge in neuroimaging-based clinical decision support systems. In this work, we propose a novel hybrid deep learning framework that integrates Topological Data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Faisal Ahmed

Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming traditional statistical techniques. However, to establish ML as a reliable tool in clinical practice, adherence to best practices regarding data…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Rosanna Turrisi , Alessandro Verri , Annalisa Barla

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

Autism spectrum disorder (ASD) affects the brain connectivity at different levels. Nonetheless, non-invasively distinguishing such effects using magnetic resonance imaging (MRI) remains very challenging to machine learning diagnostic…

Machine Learning · Computer Science 2020-04-29 Ismail Bilgen , Goktug Guvercin , Islem Rekik

Accurate diagnosis of Parkinson disease, especially in its early stages, can be a challenging task. The application of machine learning techniques helps improve the diagnostic accuracy of Parkinson disease detection but only few studies…

Machine Learning · Computer Science 2024-12-25 Majid Ali , Hina Shakir , Asia Samreen , Sohaib Ahmed

Structural magnetic resonance imaging (sMRI) combined with deep learning has achieved remarkable progress in the prediction and diagnosis of Alzheimer's disease (AD). Existing studies have used CNN and transformer to build a well-performing…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Zheng Yang , Yanteng Zhang , Xupeng Kou , Yang Liu , Chao Ren

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

Traditional approaches for molecular imaging of Parkinson's disease (PD) in vivo require radioactive isotopes, lengthy scan times, or deliver only low spatial resolution. Recent advances in saturation transfer-based PD magnetic resonance…

Medical Physics · Physics 2025-12-24 Hagar Shmuely , Michal Rivlin , Or Perlman

Alzheimer's Disease (AD) is the most common form of dementia and often difficult to diagnose due to the multifactorial etiology of dementia. Recent works on neuroimaging-based computer-aided diagnosis with deep neural networks (DNNs) showed…

Image and Video Processing · Electrical Eng. & Systems 2022-07-06 Marla Narazani , Ignacio Sarasua , Sebastian Pölsterl , Aldana Lizarraga , Igor Yakushev , Christian Wachinger

Melanoma classification is a serious stage to identify the skin disease. It is considered a challenging process due to the intra-class discrepancy of melanomas, skin lesions low contrast, and the artifacts in the dermoscopy images,…

Computer Vision and Pattern Recognition · Computer Science 2018-07-27 Yanhui Guo , Amira S. Ashour

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Parkinson's disease (PD) shows heterogeneous, evolving brain-morphometry patterns. Modeling these longitudinal trajectories enables mechanistic insight, treatment development, and individualized 'digital-twin' forecasting. However, existing…

Machine Learning · Computer Science 2025-11-10 Xiaoda Wang , Yuji Zhao , Kaiqiao Han , Xiao Luo , Sanne van Rooij , Jennifer Stevens , Lifang He , Liang Zhan , Yizhou Sun , Wei Wang , Carl Yang

Part-level representations are important for robust person re-identification (ReID), but in practice feature quality suffers due to the body part misalignment problem. In this paper, we present a robust, compact, and easy-to-use method…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Changxing Ding , Kan Wang , Pengfei Wang , Dacheng Tao