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The recent shift toward the Health Level Seven Fast Healthcare Interoperability Resources (HL7 FHIR) standard opens a new frontier for clinical AI, demanding LLM agents to navigate complex, resource-based data models instead of conventional…

Computation and Language · Computer Science 2025-11-14 Gyubok Lee , Elea Bach , Eric Yang , Tom Pollard , Alistair Johnson , Edward Choi , Yugang jia , Jong Ha Lee

Healthcare administration accounts for over $1 trillion in annual spending, making it a promising target for LLM-based computer-use agents (CUAs). While clinical applications of LLMs have received significant attention, no benchmark exists…

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

Computation and Language · Computer Science 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

Interactive multi-agent simulation algorithms are used to compute the trajectories and behaviors of different entities in virtual reality scenarios. However, current methods involve considerable parameter tweaking to generate plausible…

Graphics · Computer Science 2018-12-04 Jiaping Ren , Wei Xiang , Yangxi Xiao , Ruigang Yang , Dinesh Manocha , Xiaogang Jin

The rapid growth of ride-sharing services presents a promising solution to urban transportation challenges, such as congestion and carbon emissions. However, developing efficient operational strategies, such as pricing, matching, and fleet…

Systems and Control · Electrical Eng. & Systems 2025-05-26 Wang Chen , Hongzheng Shi , Jintao Ke

The rapid advancement of large language models (LLMs) has accelerated progress toward universal AI assistants. However, existing benchmarks for personalized assistants remain misaligned with real-world user-assistant interactions, failing…

Computation and Language · Computer Science 2026-03-13 Feiyu Duan , Xuanjing Huang , Zhongyu Wei

Doctor-patient consultations require multi-turn, context-aware communication tailored to diverse patient personas. Training or evaluating doctor LLMs in such settings requires realistic patient interaction systems. However, existing…

Artificial Intelligence · Computer Science 2025-10-30 Daeun Kyung , Hyunseung Chung , Seongsu Bae , Jiho Kim , Jae Ho Sohn , Taerim Kim , Soo Kyung Kim , Edward Choi

Artificial intelligence has significantly advanced healthcare, particularly through large language models (LLMs) that excel in medical question answering benchmarks. However, their real-world clinical application remains limited due to the…

Computation and Language · Computer Science 2024-07-01 Zhihao Fan , Jialong Tang , Wei Chen , Siyuan Wang , Zhongyu Wei , Jun Xi , Fei Huang , Jingren Zhou

The recent rapid development of large language models (LLMs) has sparked a new wave of technological revolution in medical artificial intelligence (AI). While LLMs are designed to understand and generate text like a human, autonomous agents…

Artificial Intelligence · Computer Science 2025-01-20 Junkai Li , Yunghwei Lai , Weitao Li , Jingyi Ren , Meng Zhang , Xinhui Kang , Siyu Wang , Peng Li , Ya-Qin Zhang , Weizhi Ma , Yang Liu

Large language model (LLM) agents extend generative models with reasoning, tool use, and persistent memory, thereby enabling the automation of complex tasks. In healthcare, such systems could support documentation, care coordination, and…

Artificial Intelligence · Computer Science 2026-03-24 Wenxian Yang , Hanzheng Qiu , Bangqun Zhang , Chengquan Li , Zhiyong Huang , Xiaobin Feng , Rongshan Yu , Jiahong Dong

The rapid advancement of Large Language Models (LLMs) has stimulated interest in multi-agent collaboration for addressing complex medical tasks. However, the practical advantages of multi-agent collaboration approaches remain insufficiently…

Artificial Intelligence · Computer Science 2025-10-31 Yinghao Zhu , Ziyi He , Haoran Hu , Xiaochen Zheng , Xichen Zhang , Zixiang Wang , Junyi Gao , Liantao Ma , Lequan Yu

Large language models (LLMs) integrated into agent-driven workflows hold immense promise for healthcare, yet a significant gap exists between their potential and practical implementation within clinical settings. To address this, we present…

Federated learning (FL) allows collaborative model training across healthcare sites without sharing sensitive patient data. However, real-world FL deployment is often hindered by complex operational challenges that demand substantial human…

Machine Learning · Computer Science 2025-09-30 Pramit Saha , Joshua Strong , Divyanshu Mishra , Cheng Ouyang , J. Alison Noble

Virtual environments are essential to AI agent research. Existing environments for LLM agent research typically focus on either physical task solving or social simulation, with the former oversimplifying agent individuality and social…

Multiagent Systems · Computer Science 2025-06-17 Dekun Wu , Frederik Brudy , Bang Liu , Yi Wang

Agentic workflows are composed of sequences of interdependent Large Language Model (LLM) calls, and they have become a dominant workload in modern AI systems. These workflows exhibit extensive redundancy from overlapping prompts and…

Multiagent Systems · Computer Science 2026-03-18 Noppanat Wadlom , Junyi Shen , Yao Lu

Background: We present a Patient Simulator that leverages real world patient encounters which cover a broad range of conditions and symptoms to provide synthetic test subjects for development and testing of healthcare agentic models. The…

Computation and Language · Computer Science 2025-06-05 Sina Rashidian , Nan Li , Jonathan Amar , Jong Ha Lee , Sam Pugh , Eric Yang , Geoff Masterson , Myoung Cha , Yugang Jia , Akhil Vaid

Decades' advances in digital health technologies, such as electronic health records, have largely streamlined routine clinical processes. Yet, most these systems are still hard to learn and use: Clinicians often face the burden of managing…

Artificial Intelligence · Computer Science 2025-09-16 Jared Zhu , Junde Wu

Workflows play a crucial role in enhancing enterprise efficiency by orchestrating complex processes with multiple tools or components. However, hand-crafted workflow construction requires expert knowledge, presenting significant technical…

Computation and Language · Computer Science 2025-03-31 Hanchao Liu , Rongjun Li , Weimin Xiong , Ziyu Zhou , Wei Peng

As Large Language Model (LLM) agents transition from single-session tools to persistent systems managing longitudinal healthcare journeys, their memory architectures face a critical challenge: reconciling two imperfect sources of truth. The…

Machine Learning · Computer Science 2026-05-01 Samuel L Pugh , Eric Yang , Alexander Muir Sutherland , Alessandra Breschi
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