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The problem of finding longest common subsequence (LCS) is one of the fundamental problems in computer science, which finds application in fields such as computational biology, text processing, information retrieval, data compression etc.…

Computational Complexity · Computer Science 2020-06-25 Amey Bhangale , Diptarka Chakraborty , Rajendra Kumar

Recently, due to the genomic sequence analysis in several types of cancer, the genomic data based on {\em copy number profiles} ({\em CNP} for short) are getting more and more popular. A CNP is a vector where each component is a…

Data Structures and Algorithms · Computer Science 2020-02-13 Manuel Lafond , Binhai Zhu , Peng Zou

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

Correlation Clustering (CC) is a foundational problem in unsupervised learning that models binary similarity relations using labeled graphs. While classical CC has been widely studied, many real-world applications involve more nuanced…

Data Structures and Algorithms · Computer Science 2025-09-23 Chenglin Fan , Dahoon Lee , Euiwoong Lee

Graph Edit Distance (GED) is defined as the minimum cost transformation of one graph into another and is a widely adopted metric for measuring the dissimilarity between graphs. The major problem of GED is that its computation is NP-hard,…

Machine Learning · Computer Science 2026-02-24 Francesco Leonardi , Markus Orsi , Jean-Louis Reymond , Kaspar Riesen

Graph similarity computation (GSC) is to calculate the similarity between one pair of graphs, which is a fundamental problem with fruitful applications in the graph community. In GSC, graph edit distance (GED) and maximum common subgraph…

Machine Learning · Computer Science 2024-12-16 Haoran Zheng , Jieming Shi , Renchi Yang

The Edge Interdiction Clique Problem (EICP) aims to remove at most $k$ edges from a graph so as to minimize the size of the largest clique in the remaining graph. This problem captures a fundamental question in graph manipulation: which…

Data Structures and Algorithms · Computer Science 2026-01-06 Yi Zhou , Haoyu Jiang , Chenghao Zhu , André Rossi

Convolutional Neural Networks (CNNs) have recently led to incredible breakthroughs on a variety of pattern recognition problems. Banks of finite impulse response filters are learned on a hierarchy of layers, each contributing more abstract…

Computer Vision and Pattern Recognition · Computer Science 2017-07-18 Felipe Petroski Such , Shagan Sah , Miguel Dominguez , Suhas Pillai , Chao Zhang , Andrew Michael , Nathan Cahill , Raymond Ptucha

Graph Similarity Computation (GSC) is a fundamental graph related task where Graph Edit Distance (GED) serves as a prevalent metric. GED is determined by an optimal alignment between a pair of graphs that partitions each into aligned…

Machine Learning · Computer Science 2025-11-26 Zhentao Zhan , Xiaoliang Xu , Jingjing Wang , Junmei Wang

Subgraph similarity search, one of the core problems in graph search, concerns whether a target graph approximately contains a query graph. The problem is recently touched by neural methods. However, current neural methods do not consider…

Machine Learning · Computer Science 2022-10-20 Linfeng Liu , Xu Han , Dawei Zhou , Li-Ping Liu

Motivated by the recent rapid growth of research for algorithms to cluster multi-layer and temporal graphs, we study extensions of the classical Cluster Editing problem. In Multi-Layer Cluster Editing we receive a set of graphs on the same…

Discrete Mathematics · Computer Science 2018-12-14 Jiehua Chen , Hendrik Molter , Manuel Sorge , Ondrej Suchy

This study introduces the Multi-Scale Weight-Based Pairwise Coarsening and Contrastive Learning (MPCCL) model, a novel approach for attributed graph clustering that effectively bridges critical gaps in existing methods, including long-range…

Machine Learning · Computer Science 2025-07-29 Binxiong Li , Yuefei Wang , Binyu Zhao , Heyang Gao , Benhan Yang , Quanzhou Luo , Xue Li , Xu Xiang , Yujie Liu , Huijie Tang

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…

Quantitative Methods · Quantitative Biology 2017-10-04 Fereshte Mozafari , Hossein Babashah , Somayyeh Koohi , Zahra Kavehvash

The reconstruction of the history of evolutionary genome-wide events among a set of related organisms is of great biological interest. A simplified model that captures only content modifying operations was introduced recently. It allows the…

Combinatorics · Mathematics 2012-08-15 Stefan Canzar , Sandro Andreotti

The phylogenetic tree construction is to infer the evolutionary relationship between species from the experimental data. However, the experimental data are often imperfect and conflicting each others. Therefore, it is important to extract…

Artificial Intelligence · Computer Science 2007-05-23 Andy Auyeung , Ajith Abraham

Graph Neural Networks (GNNs) have emerged as powerful tools for predicting outcomes in graph-structured data. However, a notable limitation of GNNs is their inability to provide robust uncertainty estimates, which undermines their…

Machine Learning · Computer Science 2024-10-10 S. Akansha

The classic Cluster Editing problem (also known as Correlation Clustering) asks to transform a given graph into a disjoint union of cliques (clusters) by a small number of edge modifications. When applied to vertex-colored graphs (the…

Data Structures and Algorithms · Computer Science 2024-01-29 Vincent Froese , Leon Kellerhals , Rolf Niedermeier

Molecular sequence analysis is crucial for comprehending several biological processes, including protein-protein interactions, functional annotation, and disease classification. The large number of sequences and the inherently complicated…

Genomics · Quantitative Biology 2025-10-10 Sarwan Ali , Prakash Chourasia , Bipin Koirala , Murray Patterson

We introduce GSimCNN (Graph Similarity Computation via Convolutional Neural Networks) for predicting the similarity score between two graphs. As the core operation of graph similarity search, pairwise graph similarity computation is a…

Machine Learning · Computer Science 2018-11-15 Yunsheng Bai , Hao Ding , Yizhou Sun , Wei Wang

Longest common subsequence (LCS) is one of the most fundamental problems in combinatorial optimization. Apart from theoretical importance, LCS has enormous applications in bioinformatics, revision control systems, and data comparison…

Data Structures and Algorithms · Computer Science 2020-03-17 MohammadTaghi Hajiaghayi , Masoud Seddighin , Saeed Seddighin , Xiaorui Sun