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Understanding AI systems' inner workings is critical for ensuring value alignment and safety. This review explores mechanistic interpretability: reverse engineering the computational mechanisms and representations learned by neural networks…

Artificial Intelligence · Computer Science 2024-08-27 Leonard Bereska , Efstratios Gavves

In light of the recent widespread adoption of AI systems, understanding the internal information processing of neural networks has become increasingly critical. Most recently, machine vision has seen remarkable progress by scaling neural…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Roland S. Zimmermann , Thomas Klein , Wieland Brendel

The last decade of machine learning has seen drastic increases in scale and capabilities. Deep neural networks (DNNs) are increasingly being deployed in the real world. However, they are difficult to analyze, raising concerns about using…

Machine Learning · Computer Science 2023-08-22 Tilman Räuker , Anson Ho , Stephen Casper , Dylan Hadfield-Menell

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Mechanistic interpretability (MI) is an emerging framework for interpreting neural networks. Given a task and model, MI aims to discover a succinct algorithmic process, an interpretation, that explains the model's decision process on that…

Machine Learning · Computer Science 2026-04-01 Alan Sun , Mariya Toneva

Mechanistic interpretability aims to understand the computational mechanisms underlying neural networks' capabilities in order to accomplish concrete scientific and engineering goals. Progress in this field thus promises to provide greater…

Interpretable insights from predictive models remain critical in bio-statistics, particularly when assessing causality, where classical statistical and machine learning methods often provide inherent clarity. While Neural Networks (NNs)…

Applications · Statistics 2025-05-02 Jean-Baptiste A. Conan

As deep learning systems are scaled up to many billions of parameters, relating their internal structure to external behaviors becomes very challenging. Although daunting, this problem is not new: Neuroscientists and cognitive scientists…

Deep learning methods have become very popular for the processing of natural images, and were then successfully adapted to the neuroimaging field. As these methods are non-transparent, interpretability methods are needed to validate them…

Computer Vision and Pattern Recognition · Computer Science 2022-04-15 Elina Thibeau-Sutre , Sasha Collin , Ninon Burgos , Olivier Colliot

With the growing pervasiveness of artificial intelligence, the ability to explain the inferences made by machine learning models has become increasingly important. Numerous techniques for model explainability have been proposed, with…

Human-Computer Interaction · Computer Science 2026-04-08 Nicola Rossberg , Bennett Kleinberg , Barry O'Sullivan , Luca Longo , Andrea Visentin

Despite variations in architecture and pretraining strategies, recent studies indicate that large-scale AI models often converge toward similar internal representations that also align with neural activity. We propose that scale-invariance,…

Neurons and Cognition · Quantitative Biology 2025-06-17 Junjie Yu , Wenxiao Ma , Jianyu Zhang , Haotian Deng , Zihan Deng , Yi Guo , Quanying Liu

Machine learning methods can be a valuable aid in the scientific process, but they need to face challenging settings where data come from inhomogeneous experimental conditions. Recent meta-learning methods have made significant progress in…

Machine Learning · Computer Science 2024-03-21 Matthieu Blanke , Marc Lelarge

Machine learning is increasingly transforming various scientific fields, enabled by advancements in computational power and access to large data sets from experiments and simulations. As artificial intelligence (AI) continues to grow in…

Computational Physics · Physics 2025-04-01 Sebastian Johann Wetzel , Seungwoong Ha , Raban Iten , Miriam Klopotek , Ziming Liu

Interpretability of artificial intelligence (AI) methods, particularly deep neural networks, is of great interest. This heightened focus stems from the widespread use of AI-backed systems. These systems, often relying on intricate neural…

Quantum Physics · Physics 2024-11-11 Lirandë Pira , Chris Ferrie

Mechanistic interpretability is an emerging diagnostic approach for neural models that has gained traction in broader natural language processing domains. This paradigm aims to provide attribution to components of neural systems where…

Information Retrieval · Computer Science 2025-01-20 Andrew Parry , Catherine Chen , Carsten Eickhoff , Sean MacAvaney

Machine learning algorithms often assume that training samples are independent. When data points are connected by a network, the induced dependency between samples is both a challenge, reducing effective sample size, and an opportunity to…

Machine Learning · Statistics 2025-09-22 Tiffany M. Tang , Elizaveta Levina , Ji Zhu

Computationally explicit hypotheses of brain function derived from machine learning (ML)-based models have recently revolutionized neuroscience. Despite the unprecedented ability of these artificial neural networks (ANNs) to capture…

Neurons and Cognition · Quantitative Biology 2023-12-12 Kohitij Kar , Simon Kornblith , Evelina Fedorenko

Mechanistic Interpretability (MI) promises a path toward fully understanding how neural networks make their predictions. Prior work demonstrates that even when trained to perform simple arithmetic, models can implement a variety of…

Machine Learning · Computer Science 2024-05-28 Ouail Kitouni , Niklas Nolte , Víctor Samuel Pérez-Díaz , Sokratis Trifinopoulos , Mike Williams

In recent years, Artificial Intelligence has become a powerful partner for complex tasks such as data analysis, prediction, and problem-solving, yet its lack of transparency raises concerns about its reliability. In sensitive domains such…

Machine Learning · Computer Science 2026-03-10 Jesús Sánchez Ochoa , Enrique Tomás Martínez Beltrán , Alberto Huertas Celdrán

Deep neural networks have been well-known for their superb handling of various machine learning and artificial intelligence tasks. However, due to their over-parameterized black-box nature, it is often difficult to understand the prediction…

Machine Learning · Computer Science 2022-07-18 Xuhong Li , Haoyi Xiong , Xingjian Li , Xuanyu Wu , Xiao Zhang , Ji Liu , Jiang Bian , Dejing Dou
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