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We propose a new multi-scale molecular dynamics simulation method which can achieve high accuracy and high sampling efficiency simultaneously without aforehand knowledge of the coarse grained (CG) potential and test it for a biomolecular…

Biological Physics · Physics 2009-08-05 Wenfei Li , Shoji Takada

Advances in quantum simulator technology is increasingly required because research on quantum algorithms is becoming more sophisticated and complex. State vector simulation utilizes CPU and memory resources in computing nodes exponentially…

Quantum Physics · Physics 2024-09-04 Mikio Morita , Yoshinori Tomita , Junpei Koyama , Koichi Kimura

Text-to-image generation using diffusion models has seen explosive popularity owing to their ability in producing high quality images adhering to text prompts. However, production-grade diffusion model serving is a resource intensive task…

Computer Vision and Pattern Recognition · Computer Science 2023-12-08 Shubham Agarwal , Subrata Mitra , Sarthak Chakraborty , Srikrishna Karanam , Koyel Mukherjee , Shiv Saini

The accurate sampling of protein dynamics is an ongoing challenge despite the utilization of High-Performance Computers (HPC) systems. Utilizing only "brute force" MD simulations requires an unacceptably long time to solution. Adaptive…

Quantitative Methods · Quantitative Biology 2020-09-25 Eugen Hruska , Vivekanandan Balasubramanian , Hyungro Lee , Shantenu Jha , Cecilia Clementi

Novel machine learning methods for tabular data generation are often developed on small datasets which do not match the scale required for scientific applications. We investigate a recent proposal to use XGBoost as the function approximator…

Machine Learning · Computer Science 2024-08-30 Jesse C. Cresswell , Taewoo Kim

The efficacy of drug treatments depends on how tightly small molecules bind to their target proteins. The rapid and accurate quantification of the strength of these interactions (as measured by binding affinity) is a grand challenge of…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-30 Jumana Dakka , Kristof Farkas-Pall , Matteo Turilli , David W Wright , Peter V Coveney , Shantenu Jha

Numerical simulation is one of the mainstream methods in scientific research, typically performed by professional engineers. With the advancement of multi-agent technology, using collaborating agents to replicate human behavior shows…

Multiagent Systems · Computer Science 2026-01-13 Chunwei Yang , Yankai Wang , Jianxiang Tang , Haojie Qu , Ziqiang Zou , YuLiu , Chunrui Deng , Zhifang Qiu , Ming Ding

Computational modelling of diffusion in heterogeneous media is prohibitively expensive for problems with fine-scale heterogeneities. A common strategy for resolving this issue is to decompose the domain into a number of non-overlapping…

Computational Physics · Physics 2021-08-26 Nathan G. March , Elliot J. Carr , Ian W. Turner

Recent advances in fast sampling methods for diffusion models have demonstrated significant potential to accelerate generation on image modalities. We apply these methods to 3-dimensional molecular conformations by building on the recently…

Quantitative Methods · Quantitative Biology 2024-04-23 Romain Lacombe , Neal Vaidya

A simple and efficient algorithm of the molecular-dynamics simulation of the hard disk system based on the Event-Driven method is developed. From the analysis of algorithm, the complexity is O(log N) per 1 event, and the constant…

Computational Physics · Physics 2009-10-31 Masaharu Isobe

We propose a highly versatile computational framework for the simulation of cellular blood flow focusing on extreme performance without compromising accuracy or complexity. The tool couples the lattice Boltzmann solver Palabos for the…

Computational Physics · Physics 2021-07-22 Christos Kotsalos , Jonas Latt , Joel Beny , Bastien Chopard

Current GPU-accelerated supercomputers promise to enable large-scale simulations of turbulent flows. Lattice Boltzmann Methods (LBM) are particularly well-suited to fulfilling this promise due to their intrinsic compatibility with highly…

Computational Physics · Physics 2025-06-30 Adrian Kummerländer , Fedor Bukreev , Yuji Shimojima , Shota Ito , Mathias J. Krause

Mechanistic simulators are an indispensable tool for epidemiology to explore the behavior of complex, dynamic infections under varying conditions and navigate uncertain environments. Agent-based models (ABMs) are an increasingly popular…

LLM-based multi-agent simulations are increasingly adopted across application domains, but remain difficult to scale due to GPU memory pressure. Each agent maintains private GPU-resident states, including models, prefix caches, and…

Artificial Intelligence · Computer Science 2026-01-30 Zaifeng Pan , Yipeng Shen , Zhengding Hu , Zhuang Wang , Aninda Manocha , Zheng Wang , Zhongkai Yu , Yue Guan , Yufei Ding

Recently, task-based programming models have emerged as a prominent alternative among shared-memory parallel programming paradigms. Inherently asynchronous, these models provide native support for dynamic load balancing and incorporate data…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-01 Nicolas Guidotti , Pedro Ceyrat , João Barreto , José Monteiro , Rodrigo Rodrigues , Ricardo Fonseca , Xavier Martorell , Antonio J. Peña

Cell proliferation and cell movement are fundamentally stochastic processes which lead to variability in the growth and spatial structure of cell populations in many biological settings, such as cell invasion, wound healing, and tumour…

Cell Behavior · Quantitative Biology 2026-04-23 John Carlo Dimaculangan , Cameron A. Smith , Christian A. Yates

Scaling test-time computation improves large language model performance without additional training. Recent work demonstrates that techniques such as repeated sampling, self-verification, and self-reflection can significantly enhance task…

Artificial Intelligence · Computer Science 2025-12-15 Dongwon Jung , Peng Shi , Yi Zhang

Recently, a fully implicit, energy- and charge-conserving particle-in-cell method has been proposed for multi-scale, full-f kinetic simulations [G. Chen, et al., J. Comput. Phys. 230,18 (2011)]. The method employs a Jacobian-free…

Plasma Physics · Physics 2015-06-03 Guangye Chen , Luis Chacón , Daniel C. Barnes

Computational Fluid Dynamics (CFD) simulations are essential for analyzing and optimizing fluid flows in a wide range of real-world applications. These simulations involve approximating the solutions of the Navier-Stokes differential…

A model of multicellular systems with several types of cells is developed from the phase field model. The model is presented as a set of partial differential equations of the field variables, each of which expresses the shape of one cell.…

Biological Physics · Physics 2015-05-30 Makiko Nonomura