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Generative modeling over discrete data has recently seen numerous success stories, with applications spanning language modeling, biological sequence design, and graph-structured molecular data. The predominant generative modeling paradigm…

Machine Learning · Computer Science 2024-11-01 Oscar Davis , Samuel Kessler , Mircea Petrache , İsmail İlkan Ceylan , Michael Bronstein , Avishek Joey Bose

Generating molecular graphs with desired chemical properties driven by deep graph generative models provides a very promising way to accelerate drug discovery process. Such graph generative models usually consist of two steps: learning…

Machine Learning · Statistics 2020-06-19 Chengxi Zang , Fei Wang

We introduce a new paradigm for generative modeling built on Continuous Normalizing Flows (CNFs), allowing us to train CNFs at unprecedented scale. Specifically, we present the notion of Flow Matching (FM), a simulation-free approach for…

Machine Learning · Computer Science 2023-02-09 Yaron Lipman , Ricky T. Q. Chen , Heli Ben-Hamu , Maximilian Nickel , Matt Le

Distribution Matching Distillation (DMD) distills score-based generative models into efficient one-step generators, without requiring a one-to-one correspondence with the sampling trajectories of their teachers. Yet, the limited capacity of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Xiangyu Fan , Zesong Qiu , Zhuguanyu Wu , Fanzhou Wang , Zhiqian Lin , Tianxiang Ren , Dahua Lin , Ruihao Gong , Lei Yang

Designing metal-organic frameworks (MOFs) with novel chemistries is a longstanding challenge due to their large combinatorial space and complex 3D arrangements of the building blocks. While recent deep generative models have enabled…

Biomolecules · Quantitative Biology 2026-02-05 Nayoung Kim , Seongsu Kim , Sungsoo Ahn

Generative models excel at synthesizing high-fidelity samples from complex data distributions, but they often violate hard constraints arising from physical laws or task specifications. A common remedy is to project intermediate samples…

Machine Learning · Computer Science 2025-09-30 Jinhao Liang , Yixuan Sun , Anirban Samaddar , Sandeep Madireddy , Ferdinando Fioretto

Conventional physically based rendering (PBR) pipelines generate photorealistic images through computationally intensive light transport simulations. Although recent deep learning approaches leverage diffusion model priors with geometry…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Shenghao Zhang , Runtao Liu , Christopher Schroers , Yang Zhang

Discrete diffusion or flow models could enable faster and more controllable sequence generation than autoregressive models. We show that na\"ive linear flow matching on the simplex is insufficient toward this goal since it suffers from…

Biomolecules · Quantitative Biology 2024-06-03 Hannes Stark , Bowen Jing , Chenyu Wang , Gabriele Corso , Bonnie Berger , Regina Barzilay , Tommi Jaakkola

Recently, there has been a surge of interest in incorporating neural networks into particle filters, e.g. differentiable particle filters, to perform joint sequential state estimation and model learning for non-linear non-Gaussian…

Machine Learning · Computer Science 2025-01-07 Xiongjie Chen , Yunpeng Li

Atomic transport underpins the performance of materials in technologies such as energy storage and electronics, yet its simulation remains computationally demanding. In particular, modeling ionic diffusion in solid-state electrolytes (SSEs)…

Materials Science · Physics 2025-10-21 Juno Nam , Sulin Liu , Gavin Winter , KyuJung Jun , Soojung Yang , Rafael Gómez-Bombarelli

Flow Matching has limited ability in achieving one-step generation due to its reliance on learned curved trajectories. Previous studies have attempted to address this limitation by either modifying the coupling distribution to prevent…

Machine Learning · Computer Science 2025-11-25 Chenrui Ma , Xi Xiao , Tianyang Wang , Xiao Wang , Yanning Shen

Recent advances in computational materials science present novel opportunities for structure discovery and optimization, including uncovering of unsuspected compounds and metastable structures, electronic structure, surface, and…

The generation of accurate 3D molecular conformations is a pivotal challenge in computational chemistry and drug discovery. Recently, diffusion and flow matching models have achieved remarkable success. However, there is a critical…

Machine Learning · Computer Science 2026-05-26 Yunqing Liu , Yi Zhou , Wenqi Fan

Virtual instrument generation requires maintaining consistent timbre across different pitches and velocities, a challenge that existing note-level models struggle to address. We present FlowSynth, which combines distributional flow matching…

Sound · Computer Science 2025-10-27 Qihui Yang , Randal Leistikow , Yongyi Zang

Generative models can be categorized into two types: explicit generative models that define explicit density forms and allow exact likelihood inference, such as score-based diffusion models (SDMs) and normalizing flows; implicit generative…

Machine Learning · Statistics 2023-07-06 Jingwei Zhang , Han Shi , Jincheng Yu , Enze Xie , Zhenguo Li

Inorganic crystals are periodic, highly-symmetric arrangements of atoms in three-dimensional space. Their structures are constrained by the symmetry operations of a crystallographic \emph{space group} and restricted to lie in specific…

Machine Learning · Computer Science 2025-09-30 Omri Puny , Yaron Lipman , Benjamin Kurt Miller

Heterogeneous materials consisting of different phases are ideally suited to achieve a broad spectrum of desirable bulk physical properties by combining the best features of the constituents through the strategic spatial arrangement of the…

Materials Science · Physics 2017-10-10 Duyu Chen , Salvatore Torquato

We present SD3.5-Flash, an efficient few-step distillation framework that brings high-quality image generation to accessible consumer devices. Our approach distills computationally prohibitive rectified flow models through a reformulated…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Hmrishav Bandyopadhyay , Rahim Entezari , Jim Scott , Reshinth Adithyan , Yi-Zhe Song , Varun Jampani

Generating molecular dynamics (MD) trajectories using deep generative models has attracted increasing attention, yet remains inherently challenging due to the limited availability of MD data and the complexities involved in modeling…

Machine Learning · Computer Science 2026-04-07 Aniketh Iyengar , Jiaqi Han , Pengwei Sun , Mingjian Jiang , Jianwen Xie , Stefano Ermon

Mass spectrometry (MS) stands as a cornerstone analytical technique for molecular identification, yet de novo structure elucidation from spectra remains challenging due to the combinatorial complexity of chemical space and the inherent…

Machine Learning · Computer Science 2026-03-20 Jianan Nie , Peng Gao