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Autonomy is a hallmark of animal intelligence, enabling adaptive and intelligent behavior in complex environments without relying on external reward or task structure. Existing reinforcement learning approaches to exploration in reward-free…

Neurons and Cognition · Quantitative Biology 2025-10-27 Reece Keller , Alyn Kirsch , Felix Pei , Xaq Pitkow , Leo Kozachkov , Aran Nayebi

The cognitive sciences aim to understand intelligence by formalizing underlying operations as computational models. Traditionally, this follows a cycle of discovery where researchers develop paradigms, collect data, and test predefined…

Artificial Intelligence · Computer Science 2026-03-24 Akshay K. Jagadish , Milena Rmus , Kristin Witte , Marvin Mathony , Marcel Binz , Eric Schulz

The tracing of neural pathways through large volumes of image data is an incredibly tedious and time-consuming process that significantly encumbers progress in neuroscience. We are exploring deep learning's potential to automate…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 Ishtar Nyawira , Kristi Bushman , Iris Qian , Annie Zhang

Zebrafish embryos are a valuable model for drug discovery due to their optical transparency and genetic similarity to humans. However, current evaluations rely on manual inspection, which is costly and labor-intensive. While machine…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Sarath Sivaprasad , Hui-Po Wang , Anna-Lisa Jäckel , Jonas Baumann , Carole Baumann , Jennifer Herrmann , Mario Fritz

Neural dynamics underlie behaviors from memory to sleep, yet identifying mechanisms for higher-order phenomena (e.g., social interaction) is experimentally challenging. Existing whole-brain models often fail to scale to single-neuron…

Neurons and Cognition · Quantitative Biology 2025-11-03 Sam Fatehmanesh Vegas , Matt Thomson , James Gornet , David Prober

Despite the recent success of neural network models in mimicking animal performance on visual perceptual tasks, critics worry that these models fail to illuminate brain function. We take it that a central approach to explanation in systems…

Neurons and Cognition · Quantitative Biology 2021-04-13 Rosa Cao , Daniel Yamins

Understanding the complexity of biological neural networks like the human brain is one of the scientific challenges of our century. The organization of the brain can be described at different levels, ranging from small neural networks to…

Neurons and Cognition · Quantitative Biology 2018-05-23 Stefano De Blasi

Despite the success of neural networks at solving concrete physics problems, their use as a general-purpose tool for scientific discovery is still in its infancy. Here, we approach this problem by modelling a neural network architecture…

Quantum Physics · Physics 2020-01-24 Raban Iten , Tony Metger , Henrik Wilming , Lidia del Rio , Renato Renner

Automated methods for discovering mechanistic simulator models from observational data offer a promising path toward accelerating scientific progress. Such methods often take the form of agentic-style iterative workflows that repeatedly…

Machine Learning · Computer Science 2026-02-23 Stefan Wahl , Raphaela Schenk , Ali Farnoud , Jakob H. Macke , Daniel Gedon

Mechanistic models encode scientific knowledge about dynamical systems and are widely used in downstream scientific and policy applications. Recent work has explored LLM-based agentic frameworks to automatically construct mechanistic models…

Machine Learning · Computer Science 2026-02-23 Zihan Guan , Rituparna Datta , Mengxuan Hu , Shunshun Liu , Aiying Zhang , Prasanna Balachandran , Sheng Li , Anil Vullikanti

Data-driven benchmarks have led to significant progress in key scientific modeling domains including weather and structural biology. Here, we introduce the Zebrafish Activity Prediction Benchmark (ZAPBench) to measure progress on the…

Discovering symbolic representations for skills is essential for abstract reasoning and efficient planning in robotics. Previous neuro-symbolic robotic studies mostly focused on discovering perceptual symbolic categories given a pre-defined…

Robotics · Computer Science 2025-05-27 Burcu Kilic , Alper Ahmetoglu , Emre Ugur

Scientific modeling faces a tradeoff between the interpretability of mechanistic theory and the predictive power of machine learning. While existing hybrid approaches have made progress by incorporating domain knowledge into machine…

Machine Learning · Computer Science 2026-04-15 Carson Dudley , Reiden Magdaleno , Christopher Harding , Marisa Eisenberg

*Automated circuit discovery* is a central tool in mechanistic interpretability for identifying the internal components of neural networks responsible for specific behaviors. While prior methods have made significant progress, they…

Machine Learning · Computer Science 2026-02-20 Itamar Hadad , Guy Katz , Shahaf Bassan

Recent works exploring deep learning application to dynamical systems modeling have demonstrated that embedding physical priors into neural networks can yield more effective, physically-realistic, and data-efficient models. However, in the…

Neural and Evolutionary Computing · Computer Science 2020-11-30 Elliott Skomski , Jan Drgona , Aaron Tuor

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and…

Neurons and Cognition · Quantitative Biology 2019-06-10 Francesco Cremonesi , Felix Schürmann

Collective movements are pervasive behaviours among social organisms and have led to the development of many models. However, modelling animal trajectories and social interactions in simple bounded environments remains a challenge.…

Neurons and Cognition · Quantitative Biology 2018-11-28 Leo Cazenille , Nicolas Bredeche , José Halloy

Recent studies on reasoning in language models (LMs) have sparked a debate on whether they can learn systematic inferential principles or merely exploit superficial patterns in the training data. To understand and uncover the mechanisms…

Computation and Language · Computer Science 2025-06-24 Geonhee Kim , Marco Valentino , André Freitas

Delineating how animal behavior arises from neural activity is a foundational goal of neuroscience. However, as the computations underlying behavior unfold in networks of thousands of individual neurons across the entire brain, this…

Neurons and Cognition · Quantitative Biology 2025-07-04 Jacob J. Morra , Kaitlyn E. Fouke , Kexin Hang , Zichen He , Owen Traubert , Timothy W. Dunn , Eva A. Naumann

Better understanding the natural world is a crucial task with a wide range of applications. In environments with close proximity between humans and animals, such as zoos, it is essential to better understand the causes behind animal…

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