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While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual…

Machine Learning · Computer Science 2026-03-17 Jungwoo Oh , Hyunseung Chung , Junhee Lee , Min-Gyu Kim , Hangyul Yoon , Ki Seong Lee , Youngchae Lee , Muhan Yeo , Edward Choi

Electrocardiogram (ECG) interpretation requires specialized expertise, often involving synthesizing insights from ECG signals with complex clinical queries posed in natural language. The scarcity of labeled ECG data coupled with the diverse…

Machine Learning · Computer Science 2025-05-09 Jialu Tang , Tong Xia , Yuan Lu , Cecilia Mascolo , Aaqib Saeed

Electrocardiogram (ECG) monitoring is one of the most powerful technique of cardiovascular disease (CVD) early identification, and the introduction of intelligent wearable ECG devices has enabled daily monitoring. However, due to the need…

Signal Processing · Electrical Eng. & Systems 2024-03-08 Hongxiang Gao , Xingyao Wang , Zhenghua Chen , Min Wu , Jianqing Li , Chengyu Liu

The electrocardiogram (ECG) is an essential non-invasive diagnostic tool for assessing cardiac conditions. Existing automatic interpretation methods suffer from limited generalizability, focusing on a narrow range of cardiac conditions, and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Ruoqi Liu , Yuelin Bai , Xiang Yue , Ping Zhang

While recent multimodal large language models (MLLMs) have advanced automated ECG interpretation, they still face two key limitations: (1) insufficient multimodal synergy between time series signals and visual ECG representations, and (2)…

Computation and Language · Computer Science 2025-10-21 Xiang Lan , Feng Wu , Kai He , Qinghao Zhao , Shenda Hong , Mengling Feng

Recent advances have increasingly applied large language models (LLMs) to electrocardiogram (ECG) interpretation, giving rise to Electrocardiogram-Language Models (ELMs). Conditioned on an ECG and a textual query, an ELM autoregressively…

Artificial Intelligence · Computer Science 2025-05-27 William Han , Chaojing Duan , Zhepeng Cen , Yihang Yao , Xiaoyu Song , Atharva Mhaskar , Dylan Leong , Michael A. Rosenberg , Emerson Liu , Ding Zhao

Automated interpretation of electrocardiograms (ECG) has garnered significant attention with the advancements in machine learning methodologies. Despite the growing interest, most current studies focus solely on classification or regression…

Signal Processing · Electrical Eng. & Systems 2023-11-07 Jielin Qiu , Jiacheng Zhu , Shiqi Liu , William Han , Jingqi Zhang , Chaojing Duan , Michael Rosenberg , Emerson Liu , Douglas Weber , Ding Zhao

Electroencephalography (EEG) interpretation using multimodal large language models (MLLMs) offers a novel approach for analyzing brain signals. However, the complex nature of brain activity introduces critical challenges: EEG signals…

Signal Processing · Electrical Eng. & Systems 2025-10-02 Ziyi Zeng , Zhenyang Cai , Yixi Cai , Xidong Wang , Junying Chen , Rongsheng Wang , Yipeng Liu , Siqi Cai , Benyou Wang , Zhiguo Zhang , Haizhou Li

Electrocardiography (ECG) offers critical cardiovascular insights, such as identifying arrhythmias and myocardial ischemia, but enabling automated systems to answer complex clinical questions directly from ECG signals (ECG-QA) remains a…

Signal Processing · Electrical Eng. & Systems 2025-05-13 Hung Manh Pham , Jialu Tang , Aaqib Saeed , Dong Ma

Multimodal large language models (MLLMs) are increasingly being applied in the medical field, particularly in medical imaging. However, developing MLLMs for ECG signals, which are crucial in clinical settings, has been a significant…

Computation and Language · Computer Science 2024-11-25 Haitao Li , Ziyu Li , Yiheng Mao , Ziyi Liu , Zhoujian Sun , Zhengxing Huang

The advent of multimodal large language models (MLLMs) has sparked interest in their application to electrocardiogram (ECG) analysis. However, existing ECG-focused MLLMs primarily focus on report generation tasks, often limited to single…

Computation and Language · Computer Science 2025-11-13 Haitao Li , Ziyu Li , Yiheng Mao , Ziyi Liu , Zhoujian Sun , Zhengxing Huang

Electrocardiography (ECG) plays a central role in cardiovascular diagnostics, yet existing automated approaches often struggle to generalize across clinical tasks and offer limited support for open-ended reasoning. We present HeartLLM, a…

Artificial Intelligence · Computer Science 2026-01-27 Jinning Yang , Wenjie Sun , Wen Shi

Electrocardiogram (ECG) is widely used in healthcare applications, such as arrhythmia detection and sleep monitoring, making accurate ECG analysis critically essential. Traditional deep learning models for ECG are task-specific, with…

Signal Processing · Electrical Eng. & Systems 2025-10-14 Yu Han , Vittorio Murino , Xiaofeng Liu , Xiang Zhang , Cheng Ding

The electrocardiogram (ECG) is an essential and effective tool for diagnosing heart diseases. However, its effectiveness can be compromised by noise or unavailability of one or more leads of the standard 12-lead recordings, resulting in…

Machine Learning · Computer Science 2025-10-07 Huynh Dang Nguyen , Trong-Thang Pham , Ngan Le , Van Nguyen

Electrocardiogram (ECG) is a widely used tool for assessing cardiac function due to its low cost and accessibility. Emergent research shows that ECGs can help make predictions on key outcomes traditionally derived from more complex…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Chris McIntosh

Large Language Models (LLMs) hold significant promise for electrocardiogram (ECG) analysis, yet challenges remain regarding transferability, time-scale information learning, and interpretability. Current methods suffer from model-specific…

Artificial Intelligence · Computer Science 2025-09-17 Yong Xia , Jingxuan Li , YeTeng Sun , Jiarui Bu

High-fidelity ECG interpretation is increasingly reliant on massive foundation models, yet their deployment in clinical edge-care remains hindered by extreme computational demands. While knowledge distillation (KD) is a promising solution,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Dang Hong Nguyen , Nhi Ngoc-Yen Nguyen , Huy-Hieu Pham

Electrocardiogram (ECG) interpretation is a cornerstone of cardiac diagnostics. This paper explores a practical approach to enhance ECG image interpretation using the multimodal LLaMA 3.2 model. We used a parameter-efficient fine-tuning…

Computer Vision and Pattern Recognition · Computer Science 2025-02-03 Nandakishor M , Anjali M

Electrocardiogram (ECG) signals, profiling the electrical activities of the heart, are used for a plethora of diagnostic applications. However, ECG systems require multiple leads or channels of signals to capture the complete view of the…

Signal Processing · Electrical Eng. & Systems 2024-05-31 Nabil Ibtehaz , Masood Mortazavi

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan
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