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The emergence of optical circular dichroism in chiral nanoscale and molecular systems provides not only a way for analyzing the sample chirality itself but also additional degrees of freedom in manipulating light. Such manipulation can be…

Mesoscale and Nanoscale Physics · Physics 2026-02-18 Marek Zálešák , Martin Ošmera , Martin Hrtoň , Andrea Konečná

Structure-based virtual screening must address a combinatorial explosion arising from up to 10^60 drug-like molecules, multiple conformations of proteins and ligands, and all possible spatial translations and rotations of ligands within the…

Quantum Physics · Physics 2025-05-14 Pei-Kun Yang

Quantum computational chemistry has emerged as an important application of quantum computing. Hybrid quantum-classical computing methods, such as variational quantum eigensolvers (VQE), have been designed as promising solutions to quantum…

We demonstrate the first end-to-end integration of high-performance computing (HPC), reliable quantum computing, and AI in a case study on catalytic reactions producing chiral molecules. We present a hybrid computation workflow to determine…

Optimally-shaped electromagnetic fields have the capacity to coherently control the dynamics of quantum systems and thus offer a promising means for controlling molecular transformations relevant to chemical, biological, and materials…

Quantum Physics · Physics 2021-06-08 Alicia B. Magann , Matthew D. Grace , Herschel A. Rabitz , Mohan Sarovar

Band structure is a cornerstone to understand electronic properties of materials. Accurate band structure calculations using a high-level quantum-chemistry theory can be computationally very expensive. It is promising to speed up such…

Quantum Physics · Physics 2021-09-13 Yi Fan , Jie Liu , Zhenyu Li , Jinlong Yang

In what has been described as the fourth age of Quantum Chemistry, variational nuclear motion programs are now routinely being used to obtain the vibration-rotation levels and corresponding wavefunctions of small molecules to the sort of…

Chemical Physics · Physics 2016-09-23 Jonathan Tennyson

Understanding the relationship between atomic structure (order) and chemical composition (chemistry) is critical for advancing materials science, yet traditional spectroscopic techniques can be slow and damaging to sensitive samples.…

Materials Science · Physics 2025-08-29 Mridul Kumar , Yevgeny Rakita

An accurate description of strong correlation is quintessential for the exploration of emerging chemical phenomena. While near-term variational quantum algorithms provide a theoretically scalable framework for quantum chemical problems, the…

Quantum Physics · Physics 2025-10-20 Arpan Choudhury , Sonaldeep Halder , Rahul Maitra , Debashree Ghosh

The circular dichroism (ICD) induced from interaction of chiral molecules with achiral plasmonic metal nanostructures has improved sensitivity of molecular chirality detection. Although experimental results have presented several orders…

Quantum computers have been proposed as a solution for efficiently solving non-linear differential equations (DEs), a fundamental task across diverse technological and scientific domains. However, a crucial milestone in this regard is to…

Quantum Physics · Physics 2025-03-31 Annie Paine , Casper Gyurik , Antonio Andrea Gentile

The need to acquire multiple angle-resolved electron energy loss spectra (EELS) is one of the several critical challenges associated with electron magnetic circular dichroism (EMCD) experiments. If the experiments are performed by scanning…

I summarize two recent applications of chiral perturbation theory to electromagnetic reactions on deuterium: elastic electron-deuteron scattering, and Compton scattering on deuterium. Both calculations have now been carried out to three…

Nuclear Theory · Physics 2009-11-11 Daniel R. Phillips

Chirality is a fundamental molecular property that governs stereospecific behavior in chemistry and biology. Capturing chirality in machine learning models remains challenging due to the geometric complexity of stereochemical relationships…

Machine Learning · Computer Science 2026-02-10 Runhan Shi , Zhicheng Zhang , Letian Chen , Gufeng Yu , Yang Yang

In electronic structure theory, variational methods offer a valuable paradigm for approximating electronic ground states. However, for historical reasons, this principle is mostly restricted to model chemistries in pre-defined fixed basis…

Quantum Physics · Physics 2025-11-17 Fabian Langkabel , Stefan Knecht , Jakob S. Kottmann

The near-field interaction of plasmonic nanostructures and chiral molecules induces circular dichroism in achiral nanostructure. The induced circular dichroism (ICD) strength is several orders greater than the molecular inherent CD (MCD),…

Optical chirality is central to many industrial photonic technologies including enantiomer identification, ellipsometry-based tomography and spin multiplexing in optical communication. However, a substantial chiral response requires a…

Optics · Physics 2018-07-11 Longqing Cong , Prakash Pitchappa , Nan Wang , Ranjan Singh

We have analysed a number of experimental geometries (two and three-beam geometry, general systematic row setup, zone axis orientation) for the electron magnetic circular dichroism measurements (EMCD). The effect of asymmetries in those…

Materials Science · Physics 2009-10-21 J. Rusz

The differential response of chiral molecules to incident left- and right- handed circularly polarized light is used for sensing the handedness of molecules. Currently, significant effort is directed towards enhancing weak differential…

Endocrine-disrupting chemicals (EDCs) threaten human health, ecosystems, and biodiversity by interfering with hormonal signaling pathways conserved across vertebrates. Traditional in vivo assays are costly and time-consuming, limiting their…

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