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Disease modifying therapies for Alzheimer's disease demand precise timing decisions, yet current predictive models require longitudinal observations and provide no uncertainty quantification, rendering them impractical at the critical first…

Machine Learning · Computer Science 2026-04-13 Alireza Moayedikia , Sara Fin , Uffe Kock Wiil

Discrete Choice Modelling serves as a robust framework for modelling human choice behaviour across various disciplines. Building a choice model is a semi structured research process that involves a combination of a priori assumptions,…

Econometrics · Economics 2025-06-09 Gabriel Nova , Sander van Cranenburgh , Stephane Hess

Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream…

Machine Learning · Computer Science 2019-10-02 S. Soroush Haj Zargarbashi , Bagher Babaali

The use of neural networks for diagnosis classification is becoming more and more prevalent in the medical imaging community. However, deep learning method outputs remain hard to explain. Another difficulty is to choose among the large…

Image and Video Processing · Electrical Eng. & Systems 2020-02-11 Elina Thibeau Sutre , Olivier Colliot , Didier Dormont , Ninon Burgos

Cooperation and competition between human players in repeated microeconomic games offer a powerful window onto social phenomena such as the establishment, breakdown and repair of trust. This offers the prospect of particular insight into…

Neurons and Cognition · Quantitative Biology 2018-07-04 Andreas Hula , Iris Vilares , Peter Dayan , P. Read Montague

Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological…

Machine Learning · Computer Science 2023-04-20 Nair Bini Balakrishnan , P. S. Sreeja , Jisha Jose Panackal

Games have long been a microcosm for studying planning and reasoning in both natural and artificial intelligence, especially with a focus on expert-level or even super-human play. But real life also pushes human intelligence along a…

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by…

The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the…

Predicting individual cognitive decline in Alzheimer's disease (AD) is difficult due to the heterogeneity of disease progression. Reliable clinical tools require not only high accuracy but also fairness across demographics and robustness to…

Artificial Intelligence · Computer Science 2026-04-27 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

This paper presents a general framework for obtaining interpretable multivariate discriminative models that allow efficient statistical inference for neuroimage analysis. The framework, termed generative discriminative machine (GDM),…

Applications · Statistics 2019-06-04 Erdem Varol , Aristeidis Sotiras , Ke Zeng , Christos Davatzikos

Deep learning has shown significant potential in diagnosing neurodegenerative diseases from MRI data. However, most existing methods rely heavily on large volumes of labeled data and often yield representations that lack interpretability.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Fangqi Cheng , Yingying Zhao , Xiaochen Yang

Parkinson's Disease PD is a progressive neurodegenerative disorder that affects motor and cognitive functions with early diagnosis being critical for effective clinical intervention Electroencephalography EEG offers a noninvasive and…

Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction.…

Neurons and Cognition · Quantitative Biology 2018-09-10 Ming Song , Yi Yang , Jianghong He , Zhengyi Yang , Shan Yu , Qiuyou Xie , Xiaoyu Xia , Yuanyuan Dang , Qiang Zhang , Xinhuai Wu , Yue Cui , Bing Hou , Ronghao Yu , Ruxiang Xu , Tianzi Jiang

Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Wenjie Kang , Lize Jiskoot , Peter De Deyn , Geert Biessels , Huiberdina Koek , Jurgen Claassen , Huub Middelkoop , Wiesje Flier , Willemijn J. Jansen , Stefan Klein , Esther Bron

Timely implementation of interventions to slow cognitive decline among older adults requires accurate monitoring to detect changes in cognitive function. Data gathered using wearable devices that can continuously monitor factors known to be…

Signal Processing · Electrical Eng. & Systems 2024-03-26 Collin Sakal , Tingyou Li , Juan Li , Xinyue Li

We develop a probabilistic graphical model (PGM) for artificially intelligent (AI) agents to infer human beliefs during a simulated urban search and rescue (USAR) scenario executed in a Minecraft environment with a team of three players.…

Machine Learning · Computer Science 2023-10-20 Paulo Soares , Adarsh Pyarelal , Kobus Barnard

Alzheimer's patients gradually lose their ability to think, behave, and interact with others. Medical history, laboratory tests, daily activities, and personality changes can all be used to diagnose the disorder. A series of time-consuming…

Machine Learning · Computer Science 2022-12-02 Md. Sharifur Rahman , Professor Girijesh Prasad

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which…