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We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Diffusion models have revolutionized high-fidelity image and video synthesis, yet their computational demands remain prohibitive for real-time applications. These models face two fundamental challenges: strict temporal dependencies…

Machine Learning · Computer Science 2025-09-16 Jiacheng Liu , Chang Zou , Yuanhuiyi Lyu , Fei Ren , Shaobo Wang , Kaixin Li , Linfeng Zhang

Deep learning models have made significant advances in histological prediction tasks in recent years. However, for adaptation in clinical practice, their lack of robustness to varying conditions such as staining, scanner, hospital, and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 David Jacob Drexlin , Jonas Dippel , Julius Hense , Niklas Prenißl , Grégoire Montavon , Frederick Klauschen , Klaus-Robert Müller

Latent diffusion models for medical image super-resolution universally inherit variational autoencoders designed for natural photographs. We show that this default choice, not the diffusion architecture, is the dominant constraint on…

Uniform-state discrete diffusion models excel at few-step generation and guidance due to their ability to self-correct, making them preferred over autoregressive or Masked diffusion models in these settings. However, their sampling quality…

Machine Learning · Computer Science 2026-05-19 Justin Deschenaux , Caglar Gulcehre , Subham Sekhar Sahoo

Over the past few years, self-supervised monocular depth estimation that does not depend on ground-truth during the training phase has received widespread attention. Most efforts focus on designing different types of network architectures…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Shuwei Shao , Zhongcai Pei , Weihai Chen , Dingchi Sun , Peter C. Y. Chen , Zhengguo Li

Diffusion-based generative models are extremely effective in generating high-quality images, with generated samples often surpassing the quality of those produced by other models under several metrics. One distinguishing feature of these…

Machine Learning · Computer Science 2022-10-25 Ashwini Pokle , Zhengyang Geng , Zico Kolter

Efficiently identifying accurate correspondences between point clouds is crucial for both rigid and non-rigid point cloud registration. Existing methods usually rely on geometric or semantic feature embeddings to establish correspondences…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Haihua Shi , Qianliang Wu

With the growing interest in foundation models for brain signals, graph-based pretraining has emerged as a promising paradigm for learning transferable representations from connectome data. However, existing contrastive and masked…

Machine Learning · Computer Science 2026-03-10 Xinxu Wei , Rong Zhou , Lifang He , Yu Zhang

Autoregressive models are predominant in natural language generation, while their application in tabular data remains underexplored. We posit that this can be attributed to two factors: 1) tabular data contains heterogeneous data type,…

Machine Learning · Computer Science 2024-10-30 Hengrui Zhang , Liancheng Fang , Qitian Wu , Philip S. Yu

Diffusion models have become the de facto framework for generating new datasets. The core of these models lies in the ability to reverse a diffusion process in time. The goal of this manuscript is to explain, from a PDE perspective, how…

Probability · Mathematics 2025-01-29 Fei Cao , Kimball Johnston , Thomas Laurent , Justin Le , Sébastien Motsch

Multimodal generative models that can understand and generate across multiple modalities are dominated by autoregressive (AR) approaches, which process tokens sequentially from left to right, or top to bottom. These models jointly handle…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Alexander Swerdlow , Mihir Prabhudesai , Siddharth Gandhi , Deepak Pathak , Katerina Fragkiadaki

Social recommendation has emerged as a powerful approach to enhance personalized recommendations by leveraging the social connections among users, such as following and friend relations observed in online social platforms. The fundamental…

Information Retrieval · Computer Science 2024-06-05 Zongwei Li , Lianghao Xia , Chao Huang

Although recent research applying text-to-image (T2I) diffusion models to real-world super-resolution (SR) has achieved remarkable progress, the misalignment of their targets leads to a suboptimal trade-off between inference speed and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Yan Wang , Shijie Zhao , Kexin Zhang , Junlin Li , Li Zhang

Semi-supervised learning utilizes insights from unlabeled data to improve model generalization, thereby reducing reliance on large labeled datasets. Most existing studies focus on limited samples and fail to capture the overall data…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Xiuzhen Guo , Lianyuan Yu , Ji Shi , Na Lei , Hongxiao Wang

Existing diffusion models show great potential for identity-preserving generation. However, personalized portrait generation remains challenging due to the diversity in user profiles, including variations in appearance and lighting…

Computer Vision and Pattern Recognition · Computer Science 2025-02-03 Han Yang , Enis Simsar , Sotiris Anagnostidis , Yanlong Zang , Thomas Hofmann , Ziwei Liu

Denoising diffusion models represent a recent emerging topic in computer vision, demonstrating remarkable results in the area of generative modeling. A diffusion model is a deep generative model that is based on two stages, a forward…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Mubarak Shah

Diffusion Models have become a cornerstone of modern generative AI for their exceptional generation quality and controllability. However, their inherent \textit{multi-step iterations} and \textit{complex backbone networks} lead to…

Prevailing Dataset Distillation (DD) methods leveraging generative models confront two fundamental limitations. First, despite pioneering the use of diffusion models in DD and delivering impressive performance, the vast majority of…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Letian Zhou , Songhua Liu , Xinchao Wang

Spatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a…

Genomics · Quantitative Biology 2024-03-19 Xiaoyu Li , Wenwen Min , Shunfang Wang , Changmiao Wang , Taosheng Xu
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