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Score-based diffusion models (SDMs) have emerged as a powerful tool for sampling from the posterior distribution in Bayesian inverse problems. However, existing methods often require multiple evaluations of the forward mapping to generate a…

Machine Learning · Statistics 2026-05-07 Fabian Schneider , Duc-Lam Duong , Matti Lassas , Maarten V. de Hoop , Tapio Helin

Diffuse optical tomography (DOT) utilises near-infrared light for imaging spatially distributed optical parameters, typically the absorption and scattering coefficients. The image reconstruction problem of DOT is an ill-posed inverse…

Computational Physics · Physics 2021-12-15 Meghdoot Mozumder , Andreas Hauptmann , Ilkka Nissilä , Simon R. Arridge , Tanja Tarvainen

Score-based diffusion models provide a powerful way to model images using the gradient of the data distribution. Leveraging the learned score function as a prior, here we introduce a way to sample data from a conditional distribution given…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Hyungjin Chung , Jong Chul Ye

We propose a framework to perform Bayesian inference using conditional score-based diffusion models to solve a class of inverse problems in mechanics involving the inference of a specimen's spatially varying material properties from noisy…

Solving ill-posed inverse problems requires careful formulation of prior beliefs over the signals of interest and an accurate description of their manifestation into noisy measurements. Handcrafted signal priors based on e.g. sparsity are…

Machine Learning · Computer Science 2025-08-14 Tristan S. W. Stevens , Hans van Gorp , Faik C. Meral , Junseob Shin , Jason Yu , Jean-Luc Robert , Ruud J. G. van Sloun

Since their initial introduction, score-based diffusion models (SDMs) have been successfully applied to solve a variety of linear inverse problems in finite-dimensional vector spaces due to their ability to efficiently approximate the…

Machine Learning · Statistics 2023-10-31 Lorenzo Baldassari , Ali Siahkoohi , Josselin Garnier , Knut Solna , Maarten V. de Hoop

Score-based methods, such as diffusion models and Bayesian inverse problems, are often interpreted as learning the data distribution in the low-noise limit ($\sigma \to 0$). In this work, we propose an alternative perspective: their success…

Machine Learning · Statistics 2026-03-17 Xiang Li , Zebang Shen , Ya-Ping Hsieh , Niao He

Score-based diffusion models learn to reverse a stochastic differential equation that maps data to noise. However, for complex tasks, numerical error can compound and result in highly unnatural samples. Previous work mitigates this drift…

Machine Learning · Statistics 2023-06-12 Aaron Lou , Stefano Ermon

Score-based diffusion models have recently been extended to infinite-dimensional function spaces, with uses such as inverse problems arising from partial differential equations. In the Bayesian formulation of inverse problems, the aim is to…

Machine Learning · Computer Science 2026-05-12 Elizabeth L. Baker , Alexander Denker , Jes Frellsen

Score-based diffusion modeling is a generative machine learning algorithm that can be used to sample from complex distributions. They achieve this by learning a score function, i.e., the gradient of the log-probability density of the data,…

Machine Learning · Computer Science 2025-12-17 Dibyajyoti Chakraborty , Haiwen Guan , Jason Stock , Troy Arcomano , Guido Cervone , Romit Maulik

Priors are essential for reconstructing images from noisy and/or incomplete measurements. The choice of the prior determines both the quality and uncertainty of recovered images. We propose turning score-based diffusion models into…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Berthy T. Feng , Jamie Smith , Michael Rubinstein , Huiwen Chang , Katherine L. Bouman , William T. Freeman

We propose a surrogate function for efficient yet principled use of score-based priors in Bayesian imaging. We consider ill-posed inverse imaging problems in which one aims for a clean image posterior given incomplete or noisy measurements.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Berthy T. Feng , Katherine L. Bouman

Score-based diffusion models have significantly advanced generative deep learning for image processing. Measurement conditioned models have also been applied to inverse problems such as CT reconstruction. However, the conventional approach,…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Dufan Wu , Quanzheng Li

Diffusion models have recently emerged as a powerful framework for generative modeling. They consist of a forward process that perturbs input data with Gaussian white noise and a reverse process that learns a score function to generate…

Diffuse optical tomography (DOT) is a severely ill-posed nonlinear inverse problem that seeks to estimate optical parameters from boundary measurements. In the Bayesian framework, the ill-posedness is diminished by incorporating {\em a…

Numerical Analysis · Mathematics 2023-12-06 Anssi Manninen , Meghdoot Mozumder , Tanja Tarvainen , Andreas Hauptmann

Diffusion models are widely used in applications ranging from image generation to inverse problems. However, training diffusion models typically requires clean ground-truth images, which are unavailable in many applications. We introduce…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Chicago Y. Park , Shirin Shoushtari , Hongyu An , Ulugbek S. Kamilov

Conventional score-based diffusion models (DMs) may struggle with anisotropic Gaussian diffusion processes due to the required inversion of covariance matrices in the denoising score matching training objective…

Image and Video Processing · Electrical Eng. & Systems 2025-11-18 Jeffrey Alido , Tongyu Li , Yu Sun , Lei Tian

In the field of inverse estimation for systems modeled by partial differential equations (PDEs), challenges arise when estimating high- (or even infinite-) dimensional parameters. Typically, the ill-posed nature of such problems…

Computational Engineering, Finance, and Science · Computer Science 2024-08-30 Yankun Hong , Harshit Bansal , Karen Veroy

Diffusion models are extensively used for modeling image priors for inverse problems. We introduce \emph{Diff-Unfolding}, a principled framework for learning posterior score functions of \emph{conditional diffusion models} by explicitly…

Image and Video Processing · Electrical Eng. & Systems 2025-05-22 Yuanhao Wang , Shirin Shoushtari , Ulugbek S. Kamilov

Score diffusion methods can learn probability densities from samples. The score of the noise-corrupted density is estimated using a deep neural network, which is then used to iteratively transport a Gaussian white noise density to a target…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Zahra Kadkhodaie , Stéphane Mallat , Eero P. Simoncelli
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