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Large Language Models (LLMs) have seen great advance in both academia and industry, and their popularity results in numerous open-source frameworks and techniques in accelerating LLM pre-training, fine-tuning, and inference. Training and…

Performance · Computer Science 2023-12-04 Longteng Zhang , Xiang Liu , Zeyu Li , Xinglin Pan , Peijie Dong , Ruibo Fan , Rui Guo , Xin Wang , Qiong Luo , Shaohuai Shi , Xiaowen Chu

In this work we introduce an open-ended question benchmark, ALDbench, to evaluate the performance of large language models (LLMs) in materials synthesis, and in particular in the field of atomic layer deposition, a thin film growth…

The rapid advancement of Large Language Models (LLMs) has introduced new possibilities and challenges in physics education, necessitating rigorous evaluation of their capabilities as both problem solvers and automated assessors. This paper…

Physics Education · Physics 2026-05-25 Jonah R. Donaldson , Aliya Navaz , Konstantinos Doran , Alysta Lim , Mario Campanelli

Olympiad-level benchmarks in mathematics and physics are crucial testbeds for advanced AI reasoning, but chemistry, with its unique multimodal symbolic language, has remained an open challenge. We introduce ChemO, a new benchmark built from…

Artificial Intelligence · Computer Science 2025-12-10 Qiang Xu , Shengyuan Bai , Leqing Chen , Zijing Liu , Yu Li

Recent progress has expanded the use of large language models (LLMs) in drug discovery, including synthesis planning. However, objective evaluation of retrosynthesis performance remains limited. Existing benchmarks and metrics typically…

Active learning (AL) accelerates scientific discovery by prioritizing the most informative experiments, but traditional machine learning (ML) models used in AL suffer from cold-start limitations and domain-specific feature engineering,…

Machine Learning · Computer Science 2025-12-05 Hongchen Wang , Rafael Espinosa Castañeda , Jay R. Werber , Yao Fehlis , Edward Kim , Jason Hattrick-Simpers

The startling success of ChatGPT and other large language models (LLMs) using transformer-based generative neural network architecture in applications such as natural language processing and image synthesis has many researchers excited…

Artificial Intelligence · Computer Science 2024-11-05 Venkat Venkatasubramanian , Arijit Chakraborty

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of…

Quantitative Methods · Quantitative Biology 2025-05-14 Fan Zhang , Tianyu Liu , Zhihong Zhu , Hao Wu , Haixin Wang , Donghao Zhou , Yefeng Zheng , Kun Wang , Xian Wu , Pheng-Ann Heng

The integration of artificial intelligence into various domains is rapidly increasing, with Large Language Models (LLMs) becoming more prevalent in numerous applications. This work is included in an overall project which aims to train an…

Computational Physics · Physics 2025-01-09 Christophe Bajan , Guillaume Lambard

Existing benchmarks for large language models (LLMs) are largely restricted to high- or mid-resource languages, and often evaluate performance on higher-order tasks in reasoning and generation. However, plenty of evidence points to the fact…

Computation and Language · Computer Science 2025-12-01 Emily Chang , Niyati Bafna

Large Language Models frequently generate outputs that appear scientifically reasonable yet violate fundamental principles--a phenomenon we characterize as the "plausibility-validity gap." This challenge proves especially acute in…

Machine Learning · Computer Science 2026-01-07 Malikussaid , Hilal Hudan Nuha , Isman Kurniawan

With the rapid advancement of Multimodal Large Language Models (MLLMs), numerous evaluation benchmarks have emerged. However, comprehensive assessments of their performance across diverse industrial applications remain limited. In this…

Computation and Language · Computer Science 2025-01-29 Dongyi Yi , Guibo Zhu , Chenglin Ding , Zongshu Li , Dong Yi , Jinqiao Wang

Retrosynthesis, the process of breaking down a target molecule into simpler precursors through a series of valid reactions, stands at the core of organic chemistry and drug development. Although recent machine learning (ML) research has…

Artificial Intelligence · Computer Science 2026-05-12 Haorui Wang , Jeff Guo , Lingkai Kong , Rampi Ramprasad , Philippe Schwaller , Yuanqi Du , Chao Zhang

Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language, symbolic notations, with emerging extensions to incorporate multi-modal…

Machine Learning · Computer Science 2025-05-23 Ziqing Wang , Kexin Zhang , Zihan Zhao , Yibo Wen , Abhishek Pandey , Han Liu , Kaize Ding

The synthesis of inorganic crystalline materials is essential for modern technology, especially in quantum materials development. However, designing efficient synthesis workflows remains a significant challenge due to the precise…

A well-executed graphic design typically achieves harmony in two levels, from the fine-grained design elements (color, font and layout) to the overall design. This complexity makes the comprehension of graphic design challenging, for it…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Jieru Lin , Danqing Huang , Tiejun Zhao , Dechen Zhan , Chin-Yew Lin

Contemporary large language models (LLMs) have demonstrated remarkable reasoning capabilities, particularly in specialized domains like mathematics and physics. However, their ability to generalize these reasoning skills to more general and…

Computation and Language · Computer Science 2026-04-14 Junlin Liu , Shengnan An , Shuang Zhou , Dan Ma , Shixiong Luo , Ying Xie , Yuan Zhang , Wenling Yuan , Yifan Zhou , Xiaoyu Li , Ziwen Wang , Xuezhi Cao , Xunliang Cai

Formal mathematical reasoning remains a critical challenge for artificial intelligence, hindered by limitations of existing benchmarks in scope and scale. To address this, we present FormalMATH, a large-scale Lean4 benchmark comprising…

Large language model (LLM) simulations of human behavior have the potential to revolutionize the social and behavioral sciences, if and only if they faithfully reflect real human behaviors. Current evaluations of simulation fidelity are…

Computation and Language · Computer Science 2026-04-14 Tiancheng Hu , Joachim Baumann , Lorenzo Lupo , Nigel Collier , Dirk Hovy , Paul Röttger