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How DNA-binding proteins locate specific genomic targets remains a central challenge in molecular biology. Traditional protein-centric approaches, which rely on wet-lab experiments and visualization techniques, often lack genome-wide…

Quantitative Methods · Quantitative Biology 2025-09-16 Li Yang , Dongbo Wang

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

Optical Coherence Tomography (OCT) imaging plays an important role in glaucoma diagnosis in clinical practice. Early detection and timely treatment can prevent glaucoma patients from permanent vision loss. However, only a dearth of…

Computer Vision and Pattern Recognition · Computer Science 2019-07-31 Xi Wang , Hao Chen , Luyang Luo , An-ran Ran , Poemen P. Chan , Clement C. Tham , Carol Y. Cheung , Pheng-Ann Heng

A hypercomplex representation of DNA is proposed to facilitate comparison of DNA sequences with fuzzy composition. Using hypercomplex number representation, conventional sequence analysis method, such as, dot matrix analysis, dynamic…

Quantitative Methods · Quantitative Biology 2023-08-03 Jian-Jun Shu , Yajing Li

Object-Centric Learning (OCL) aggregates image or video feature maps into object-level feature vectors, termed \textit{slots}. It's self-supervision of reconstructing the input from slots struggles with complex object textures, thus Vision…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Rongzhen Zhao , Vivienne Wang , Juho Kannala , Joni Pajarinen

Previous researches have demonstrated that the framework of dictionary learning with sparse coding, in which signals are decomposed as linear combinations of a few atoms of a learned dictionary, is well adept to reconstruction issues. This…

Computer Vision and Pattern Recognition · Computer Science 2012-03-06 Shu Kong , Donghui Wang

DNA is a promising medium for digital information storage for its exceptional density and durability. While prior studies advanced coding theory, workflow design, and simulation tools, challenges such as synthesis costs, sequencing errors,…

Emerging Technologies · Computer Science 2025-10-06 Rakesh Thakur , Lavanya Singh , Yashika , Manomay Bundawala , Aruna Kumar

Labeling of DNA molecules is a fundamental technique for DNA visualization and analysis. This process was mathematically modeled in [1], where the received sequence indicates the positions of the used labels. In this work, we develop error…

Information Theory · Computer Science 2025-11-04 Dganit Hanania , Eitan Yaakobi

With the rapid increase of available digital data, DNA storage is identified as a storage media with high density and capability of long-term preservation, especially for archival storage systems. However, the encoding density (i.e., how…

Emerging Technologies · Computer Science 2021-08-26 Bingzhe Li , Li Ou , David Du

Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to…

Genomics · Quantitative Biology 2016-07-26 Yang Liao , Gordon K Smyth , Wei Shi

This paper proposes a novel approach to improve the training efficiency and the generalization performance of Feed Forward Neural Networks (FFNNs) resorting to an optimal rescaling of input features (OFR) carried out by a Genetic Algorithm…

Machine Learning · Computer Science 2024-02-21 Federico Maria Vitrò , Marco Leonesio , Lorenzo Fagiano

For optical coherence tomography angiography (OCTA) images, a limited scanning rate leads to a trade-off between field-of-view (FOV) and imaging resolution. Although larger FOV images may reveal more parafoveal vascular lesions, their…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Weiwen Zhang , Dawei Yang , Haoxuan Che , An Ran Ran , Carol Y. Cheung , Hao Chen

In this review paper, we delve into the nascent field of molecular data storage, focusing on system implementations and code constructions. We start by providing an overview of basic concepts in synthetic and computational biology.…

Emerging Technologies · Computer Science 2023-10-10 Olgica Milenkovic , Chao Pan

Optical neural networks offer a route to low-latency and energy-efficient inference by encoding computation in light propagation. However, most existing implementations rely on planar photonic circuits or discretely spaced diffractive…

Motivation: With the development of third-generation sequencing technologies, people are able to obtain DNA sequences with lengths from 10s to 100s of kb. These long reads allow protein domain annotation without assembly, thus can produce…

Genomics · Quantitative Biology 2021-07-09 Du Nan , Jiayu Shang , Yanni Sun

Optical imaging is commonly used for both scientific and technological applications across industry and academia. In image sensing, a measurement, such as of an object's position, is performed by computational analysis of a digitized image.…

Classifying pages or text lines into font categories aids transcription because single font Optical Character Recognition (OCR) is generally more accurate than omni-font OCR. We present a simple framework based on Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2017-08-15 Chris Tensmeyer , Daniel Saunders , Tony Martinez

This paper presents a complete Optical Character Recognition (OCR) system for camera captured image/graphics embedded textual documents for handheld devices. At first, text regions are extracted and skew corrected. Then, these regions are…

Computer Vision and Pattern Recognition · Computer Science 2011-09-16 Ayatullah Faruk Mollah , Nabamita Majumder , Subhadip Basu , Mita Nasipuri

We developed OmicsMapNet approach to take advantage of existing deep leaning frameworks to analyze high-dimensional omics data as 2-dimensional images. The omics data of individual samples were first rearranged into 2D images in which…

Machine Learning · Statistics 2019-05-27 Shiyong Ma , Zhen Zhang

Object identification is one of the most fundamental and difficult issues in computer vision. It aims to discover object instances in real pictures from a huge number of established categories. In recent years, deep learning-based object…

Computer Vision and Pattern Recognition · Computer Science 2022-03-03 Venkata Beri
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