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Explainable AI has become a common term in the literature, scrutinized by computer scientists and statisticians and highlighted by psychological or philosophical researchers. One major effort many researchers tackle is constructing general…

Artificial Intelligence · Computer Science 2025-09-12 Carina Newen , Daniel Bodemer , Sonja Glantz , Emmanuel Müller , Magdalena Wischnewski , Lenka Schnaubert

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

Machine Learning · Computer Science 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

Explainable AI (XAI) aims to provide interpretations for predictions made by learning machines, such as deep neural networks, in order to make the machines more transparent for the user and furthermore trustworthy also for applications in…

Machine Learning · Computer Science 2020-06-17 Kirill Bykov , Marina M. -C. Höhne , Klaus-Robert Müller , Shinichi Nakajima , Marius Kloft

Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…

Image and Video Processing · Electrical Eng. & Systems 2021-01-07 Kuo Yang , Emad A. Mohammed

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Computer Vision, and hence Artificial Intelligence-based extraction of information from images, has increasingly received attention over the last years, for instance in medical diagnostics. While the algorithms' complexity is a reason for…

Human-Computer Interaction · Computer Science 2020-07-14 Christian Meske , Enrico Bunde

This paper surveys uncertainty-aware explainable artificial intelligence (UAXAI), examining how uncertainty is incorporated into explanatory pipelines and how such methods are evaluated. Across the literature, three recurring approaches to…

Artificial Intelligence · Computer Science 2026-03-31 Helena Löfström , Tuwe Löfström , Anders Hjort , Fatima Rabia Yapicioglu

The growing adoption of artificial intelligence in healthcare has raised concerns about the transparency and trustworthiness of AI-driven medical diagnosis systems. Many existing models operate as black boxes, limiting clinicians' ability…

Human-Computer Interaction · Computer Science 2026-04-21 Altynbek Seitenov , Ainur Nurzhanova , Azhar Bekbussinova , Yerassyl Bolatkan

Objectives: The objectives of this narrative review are to summarize the current state of AI applications in neuroimaging for early Alzheimer's disease (AD) prediction and to highlight the potential of AI techniques in improving early AD…

Machine Learning · Computer Science 2024-06-27 Thorsten Rudroff , Oona Rainio , Riku Klén

Uncertainty is a key feature of any machine learning model and is particularly important in neural networks, which tend to be overconfident. This overconfidence is worrying under distribution shifts, where the model performance silently…

Machine Learning · Computer Science 2024-03-18 Arthur Thuy , Dries F. Benoit

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

With the increasing availability of structured and unstructured data and the swift progress of analytical techniques, Artificial Intelligence (AI) is bringing a revolution to the healthcare industry. With the increasingly indispensable role…

Machine Learning · Computer Science 2020-11-09 Devam Dave , Het Naik , Smiti Singhal , Pankesh Patel

Explainable artificial intelligence (XAI) plays an indispensable role in demystifying the decision-making processes of AI, especially within the healthcare industry. Clinicians rely heavily on detailed reasoning when making a diagnosis,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Anna Stubbin , Thompson Chyrikov , Jim Zhao , Christina Chajo

Artificial Intelligence (AI) holds the potential to dramatically improve patient care. However, it is not infallible, necessitating human-AI-collaboration to ensure safe implementation. One aspect of AI safety is the models' ability to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Anna M. Wundram , Christian F. Baumgartner

Reliability in Neural Networks (NNs) is crucial in safety-critical applications like healthcare, and uncertainty estimation is a widely researched method to highlight the confidence of NNs in deployment. In this work, we propose an…

Machine Learning · Computer Science 2020-11-20 Utkarsh Sarawgi , Wazeer Zulfikar , Rishab Khincha , Pattie Maes

Uncertainty is a fundamental challenge in medical practice, but current medical AI systems fail to explicitly quantify or communicate uncertainty in a way that aligns with clinical reasoning. Existing XAI works focus on interpreting model…

Artificial Intelligence · Computer Science 2025-09-24 Xiuyi Fan

This paper addresses the unique challenges associated with uncertainty quantification in AI models when applied to patient-facing contexts within healthcare. Unlike traditional eXplainable Artificial Intelligence (XAI) methods tailored for…

Artificial Intelligence · Computer Science 2024-08-06 Adarsa Sivaprasad , Ehud Reiter

The continuous development of artificial intelligence (AI) theory has propelled this field to unprecedented heights, owing to the relentless efforts of scholars and researchers. In the medical realm, AI takes a pivotal role, leveraging…

Machine Learning · Computer Science 2024-12-04 Qiyang Sun , Alican Akman , Björn W. Schuller
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