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Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Recent advances in large language models (LLMs) have substantially improved natural language processing (NLP) applications. However, these models often inherit and amplify biases present in their training data. Although several datasets…

Computation and Language · Computer Science 2026-02-20 Shaina Raza , Mizanur Rahman , Michael R. Zhang

This study introduces a transformative framework for medical education by integrating semi-structured data with Large Language Models (LLMs), primarily OpenAIs ChatGPT3.5, to automate the creation of medical simulation scenarios.…

Computation and Language · Computer Science 2024-05-07 Scott Sumpter

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

We present MedHal, a novel large-scale dataset specifically designed to evaluate if models can detect hallucinations in medical texts. Current hallucination detection methods face significant limitations when applied to specialized domains…

Computation and Language · Computer Science 2025-10-08 Gaya Mehenni , Fabrice Lamarche , Odette Rios-Ibacache , John Kildea , Amal Zouaq

Forensic cause-of-death determination faces systemic challenges, including workforce shortages and diagnostic variability, particularly in high-volume systems like China's medicolegal infrastructure. We introduce FEAT (ForEnsic AgenT), a…

Ensuring the reliability and safety of machine learning models in open-world deployment is a central challenge in AI safety. This thesis develops both algorithmic and theoretical foundations to address key reliability issues arising from…

Machine Learning · Computer Science 2025-05-22 Xuefeng Du

Causal discovery through experimentation and intervention is fundamental to robust problem solving. It requires not just updating beliefs within a fixed framework but revising the hypothesis space itself, a capacity current AI agents lack…

Artificial Intelligence · Computer Science 2026-04-23 John Alderete , Sebastian Benthal , Connie Xu , John Xing

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Pirzada Suhail , Aditya Anand , Amit Sethi

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

The proliferation of Large Language Models (LLMs) has catalyzed a shift towards autonomous agents capable of complex reasoning and tool use. However, current agent architectures are frequently constructed using imperative, ad hoc patterns.…

Artificial Intelligence · Computer Science 2026-01-23 Yifan Zhang , Yang Yuan , Mengdi Wang , Andrew Chi-Chih Yao

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice.…

Artificial Intelligence · Computer Science 2025-11-18 Silas Ruhrberg Estévez , Nicolás Astorga , Mihaela van der Schaar

The limited data availability due to strict privacy regulations and significant resource demands severely constrains biomedical time-series AI development, which creates a critical gap between data requirements and accessibility. Synthetic…

Machine Learning · Computer Science 2025-11-25 Youngjoon Lee , Seongmin Cho , Yehhyun Jo , Jinu Gong , Hyunjoo Jenny Lee , Joonhyuk Kang

\textbf{Background:} Regulatory frameworks for AI in healthcare, including the EU AI Act and FDA guidance on AI/ML-based medical devices, require clinical decision support to demonstrate not only accuracy but auditability. Existing formal…

Artificial Intelligence · Computer Science 2026-04-24 Michael Bouzinier , Sergey Trifonov , Michael Chumack , Eugenia Lvova , Dmitry Etin

With the rapid advancement of tool-use capabilities in Large Language Models (LLMs), Retrieval-Augmented Generation (RAG) is shifting from static, one-shot retrieval toward autonomous, multi-turn evidence acquisition. However, existing…

Artificial Intelligence · Computer Science 2026-02-13 Zhanli Li , Huiwen Tian , Lvzhou Luo , Yixuan Cao , Ping Luo

The effectiveness of artificial intelligence (AI) in healthcare is significantly hindered by unstructured clinical documentation, which results in noisy, inconsistent, and logically fragmented training data. To address this challenge, we…

Machine Learning · Computer Science 2025-10-21 Dun Liu , Qin Pang , Guangai Liu , Hongyu Mou , Jipeng Fan , Yiming Miao , Pin-Han Ho , Limei Peng

Vision-language models (VLMs) have shown potential for automated radiology report generation, yet existing approaches rely on global embedding compression of volumetric data, often leading to hallucinated findings and limited anatomical…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Giuseppe A. Orlando , Paolo Papotti , Maria A. Zuluaga , Olivier Humbert , Marco Lorenzi

Automatic diagnosis is a significant application of AI in healthcare, where diagnoses are generated based on the symptom description of patients. Previous works have approached this task directly by modeling the relationship between the…

Computation and Language · Computer Science 2024-01-30 Haochun Wang , Sendong Zhao , Zewen Qiang , Nuwa Xi , Bing Qin , Ting Liu

Hallucinations in Large Language Models (LLMs), defined as the generation of content inconsistent with facts or context, represent a core obstacle to their reliable deployment in critical domains. Current research primarily focuses on…

Computation and Language · Computer Science 2026-03-20 Yanyi Liu , Qingwen Yang , Tiezheng Guo , Feiyu Qu , Jun Liu , Yingyou Wen