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Large language models (LLMs) offer a valuable technology for various applications in healthcare. However, their tendency to hallucinate and the existing reliance on proprietary systems pose challenges in environments concerning critical…

Computation and Language · Computer Science 2025-02-27 Joshua Strong , Qianhui Men , Alison Noble

Large Vision-Language Models (LVLMs) augmented with Retrieval-Augmented Generation (RAG) are increasingly employed in medical AI to enhance factual grounding through external clinical image-text retrieval. However, this reliance creates a…

Machine Learning · Computer Science 2026-01-06 Kaiwen Zuo , Zelin Liu , Raman Dutt , Ziyang Wang , Zhongtian Sun , Fan Mo , Pietro Liò

Misdiagnosis causes significant harm to healthcare systems worldwide, leading to increased costs and patient risks. MedRAG is a smart multimodal healthcare copilot equipped with powerful large language model (LLM) reasoning, designed to…

Artificial Intelligence · Computer Science 2025-06-04 Xuejiao Zhao , Siyan Liu , Su-Yin Yang , Chunyan Miao

Drug development and pharmacovigilance are frequently bottlenecked by legacy clinical reporting pipelines. These monolithic systems encode regulatory-grade logic but resist AI integration by producing opaque output with no machine-readable…

Software Engineering · Computer Science 2026-05-15 Jaime Yan

LLMs are bound to transform healthcare with advanced decision support and flexible chat assistants. However, LLMs are prone to generate inaccurate medical content. To ground LLMs in high-quality medical knowledge, LLMs have been equipped…

Computation and Language · Computer Science 2025-06-10 Qinyue Zheng , Salman Abdullah , Sam Rawal , Cyril Zakka , Sophie Ostmeier , Maximilian Purk , Eduardo Reis , Eric J. Topol , Jure Leskovec , Michael Moor

Globally, disparities in healthcare infrastructure remain stark, leaving countless communities without access to even basic services. Traditional infrastructure planning is often slow and inaccessible, and although many architects are…

Human-Computer Interaction · Computer Science 2025-11-20 Yiming Zhang , Yuejia Xu , Ziyao Wang , Xin Yan , Xiaosai Hao

Medical experts may use Artificial Intelligence (AI) systems with greater trust if these are supported by contextual explanations that let the practitioner connect system inferences to their context of use. However, their importance in…

Machine learning (ML) systems for medical imaging have demonstrated remarkable diagnostic capabilities, but their susceptibility to biases poses significant risks, since biases may negatively impact generalization performance. In this…

Machine Learning · Computer Science 2025-04-29 Haroui Ma , Francesco Quinzan , Theresa Willem , Stefan Bauer

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

Large Language Models (LLMs) promise to accelerate discovery by reasoning across the expanding scientific landscape. Yet, the challenge is no longer access to information but connecting it in meaningful, domain-spanning ways. In materials…

Artificial Intelligence · Computer Science 2026-02-10 Isabella A. Stewart , Tarjei Paule Hage , Yu-Chuan Hsu , Markus J. Buehler

The deployment of Large Language Models (LLMs) for structuring clinical data is critically hindered by their tendency to hallucinate facts and their inability to follow domain-specific rules. To address this, we introduce MedPAO, a novel…

AI-generated health misinformation poses unprecedented threats to patient safety and healthcare system trust globally. This white paper presents an explainable AI framework developed through the EPSRC INDICATE project to combat medical…

Information Retrieval · Computer Science 2025-09-05 Sueun Hong , Shuojie Fu , Ovidiu Serban , Brianna Bao , James Kinross , Francesa Toni , Guy Martin , Uddhav Vaghela

LLMs for clinical decision support often fail under small but clinically meaningful input shifts such as masking a symptom or negating a finding, despite high performance on static benchmarks. These reasoning failures frequently go…

Machine Learning · Computer Science 2025-07-30 Raj Krishnan Vijayaraj

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

While interpretable prototype networks offer compelling case-based reasoning for clinical diagnostics, their raw continuous outputs lack the semantic structure required for medical documentation. Bridging this gap via standard…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Alvaro Lopez Pellicer , Plamen Angelov , Marwan Bukhari , Yi Li , Eduardo Soares , Jemma Kerns

Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference…

Artificial Intelligence · Computer Science 2025-08-27 Karishma Thakrar , Shreyas Basavatia , Akshay Daftardar

We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal hypothesis exploration. The networks represent hypotheses…

Other Quantitative Biology · Quantitative Biology 2025-12-29 David Patrick Duys Montealegre , Alexander Fulton , Mahta Haghighat Ghahfarokhi , Abicumaran Uthamacumaran , Hector Zenil

Systematic reviews are essential for evidence-based medicine, but reviewing 1.5 million+ annual publications manually is infeasible. Current AI approaches suffer from hallucinations in systematic review tasks, with studies reporting rates…

Artificial Intelligence · Computer Science 2026-01-07 Duc Ngo , Arya Rahgoza

Clinical decision making (CDM) is a complex, dynamic process crucial to healthcare delivery, yet it remains a significant challenge for artificial intelligence systems. While Large Language Model (LLM)-based agents have been tested on…

Computation and Language · Computer Science 2025-10-13 Jie Liu , Wenxuan Wang , Zizhan Ma , Guolin Huang , Yihang SU , Kao-Jung Chang , Wenting Chen , Haoliang Li , Linlin Shen , Michael Lyu

Bias in medical artificial intelligence is conventionally viewed as a defect requiring elimination. However, human reasoning inherently incorporates biases shaped by education, culture, and experience, suggesting their presence may be…

Artificial Intelligence · Computer Science 2026-03-05 Farhad Abtahi , Mehdi Astaraki , Fernando Seoane