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Fluorescence microscopy is essential to study biological structures and dynamics. However, existing systems suffer from a tradeoff between field-of-view (FOV), resolution, and complexity, and thus cannot fulfill the emerging need of…

Optics · Physics 2022-09-09 Yujia Xue , Qianwan Yang , Guorong Hu , Kehan Guo , Lei Tian

Optical microscopy is an essential tool in biology and medicine. Imaging thin, yet non-flat objects in a single shot (without relying on more sophisticated sectioning setups) remains challenging as the shallow depth of field that comes with…

Image and Video Processing · Electrical Eng. & Systems 2020-10-14 Adrian Shajkofci , Michael Liebling

We present a semi-blind, spatially-variant deconvolution technique aimed at optical microscopy that combines a local estimation step of the point spread function (PSF) and deconvolution using a spatially variant, regularized Richardson-Lucy…

Computer Vision and Pattern Recognition · Computer Science 2019-05-21 Adrian Shajkofci , Michael Liebling

Research on multi-view stereo based on remote sensing images has promoted the development of large-scale urban 3D reconstruction. However, remote sensing multi-view image data suffers from the problems of occlusion and uneven brightness…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Yong-Qiang Mao , Hanbo Bi , Liangyu Xu , Kaiqiang Chen , Zhirui Wang , Xian Sun , Kun Fu

This paper demonstrates a practical method that can correct spatial varying blur from a set of images of the same object. The algorithm jointly estimates the object and local point spread functions~(PSF). The method prioritizes sections…

Image and Video Processing · Electrical Eng. & Systems 2020-11-04 Wouter van de Ketterij , Oleg Soloviev , Michel Verhaegen

Lensless cameras replace bulky optics with thin modulation masks, enabling compact imaging systems. However, existing methods rely on an idealized model that assumes a globally shift-invariant point spread function (PSF) and sufficiently…

Image and Video Processing · Electrical Eng. & Systems 2025-12-02 Yu Ren , Xiaoling Zhang , Xu Zhan , Xiangdong Ma , Yunqi Wang , Edmund Y. Lam , Tianjiao Zeng

Due to limited size and imperfect of the optical components in a spectrometer, aberration has inevitably been brought into two-dimensional multi-fiber spectrum image in LAMOST, which leads to obvious spacial variation of the point spread…

Instrumentation and Methods for Astrophysics · Physics 2020-10-28 Jiali Xu , Qian Yin , Ping Guo , Xin Zheng

Defocus blur is a physical consequence of the optical sensors used in most cameras. Although it can be used as a photographic style, it is commonly viewed as an image degradation modeled as the convolution of a sharp image with a…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Ali Karaali , Claudio Rosito Jung

Constrained Spherical Deconvolution (CSD) is widely used to estimate the white matter fiber orientation distribution (FOD) from diffusion MRI data. Its angular resolution depends on the maximum spherical harmonic order ($l_{max}$): low…

Images of near-field SAR contains spatial-variant sidelobes and clutter, subduing the image quality. Current image restoration methods are only suitable for small observation angle, due to their assumption of 2D spatial-invariant…

Signal Processing · Electrical Eng. & Systems 2022-10-06 Wensi Zhang , Xiaoling Zhang , Xu Zhan , Yuetonghui Xu , Jun Shi , Shunjun Wei

We present a physics-informed deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), such as diffraction limited resolution, noise, and undersampling due to low laser power conditions. The…

Materials Science · Physics 2025-01-27 Zaheer Ahmad , Junaid Shabeer , Usman Saleem , Tahir Qadeer , Abdul Sami , Zahira El Khalidi , Saad Mehmood

We present a variational Bayesian method of joint image reconstruction and point spread function (PSF) estimation when the PSF of the imaging device is only partially known. To solve this semi-blind deconvolution problem, prior…

Data Analysis, Statistics and Probability · Physics 2013-03-18 Se Un Park , Nicolas Dobigeon , Alfred O. Hero

We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function (PSF) of a…

In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the Point Spread Function (PSF) and…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Julien Ajdenbaum , Emilie Chouzenoux , Claire Lefort , Ségolène Martin , Jean-Christophe Pesquet

In the rapidly advancing field of image generation, Visual Auto-Regressive (VAR) modeling has garnered considerable attention for its innovative next-scale prediction approach. This paradigm offers substantial improvements in efficiency,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zigeng Chen , Xinyin Ma , Gongfan Fang , Xinchao Wang

We introduce a stop-code tolerant (SCT) approach to training recurrent convolutional neural networks for lossy image compression. Our methods introduce a multi-pass training method to combine the training goals of high-quality…

Computer Vision and Pattern Recognition · Computer Science 2017-05-19 Michele Covell , Nick Johnston , David Minnen , Sung Jin Hwang , Joel Shor , Saurabh Singh , Damien Vincent , George Toderici

In computer-aided diagnosis (CAD) focused on microscopy, denoising improves the quality of image analysis. In general, the accuracy of this process may depend both on the experience of the microscopist and on the equipment sensitivity and…

Image and Video Processing · Electrical Eng. & Systems 2021-05-04 Fabio Hernán Gil Zuluaga , Francesco Bardozzo , Jorge Iván Ríos Patiño , Roberto Tagliaferri

The miniaturization of optics through the use of two-dimensional metalenses has enabled novel applications in imaging. To date, single-lens imaging remains the most common configuration, in part due to the limited focusing efficiency of…

Traditional fluorescence microscopy is constrained by inherent trade-offs among resolution, field-of-view, and system complexity. To navigate these challenges, we introduce a simple and low-cost computational multi-aperture miniature…

Optics · Physics 2024-05-31 Qianwan Yang , Ruipeng Guo , Guorong Hu , Yujia Xue , Yunzhe Li , Lei Tian

The crux of resolving fine-grained visual classification (FGVC) lies in capturing discriminative and class-specific cues that correspond to subtle visual characteristics. Recently, frequency decomposition/transform based approaches have…

Computer Vision and Pattern Recognition · Computer Science 2025-11-14 Qin Xu , Lili Zhu , Xiaoxia Cheng , Bo Jiang
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