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Active learning (AL) is a machine learning algorithm that can achieve greater accuracy with fewer labeled training instances, for having the ability to ask oracles to label the most valuable unlabeled data chosen iteratively and…

Machine Learning · Computer Science 2022-09-30 Ruoyu Wang

Large Language Models (LLMs) have recently emerged as effective surrogate models and candidate generators within global optimization frameworks for expensive blackbox functions. Despite promising results, LLM-based methods often struggle in…

Machine Learning · Computer Science 2026-01-28 Andrej Schwanke , Lyubomir Ivanov , David Salinas , Fabio Ferreira , Aaron Klein , Frank Hutter , Arber Zela

The need for analysis of toxicity in new drug candidates and the requirement of doing it fast have asked the consideration of scientists towards the use of artificial intelligence tools to examine toxicity levels and to develop models to a…

Quantitative Methods · Quantitative Biology 2021-01-27 Mriganka Nath , Subhasish Goswami

We propose SLOT (Sample-specific Language Model Optimization at Test-time), a novel and parameter-efficient test-time inference approach that enhances a language model's ability to more accurately respond to individual prompts. Existing…

Computation and Language · Computer Science 2025-05-27 Yang Hu , Xingyu Zhang , Xueji Fang , Zhiyang Chen , Xiao Wang , Huatian Zhang , Guojun Qi

The exponential growth of scientific literature poses unprecedented challenges for researchers attempting to synthesize knowledge across rapidly evolving fields. We present \textbf{Agentic AutoSurvey}, a multi-agent framework for automated…

Information Retrieval · Computer Science 2025-09-24 Yixin Liu , Yonghui Wu , Denghui Zhang , Lichao Sun

Bayesian Optimization (BO) is a key methodology for accelerating molecular discovery by estimating the mapping from molecules to their properties while seeking the optimal candidate. Typically, BO iteratively updates a probabilistic…

Machine Learning · Computer Science 2025-12-17 Qi Chen , Fabio Ramos , Alán Aspuru-Guzik , Florian Shkurti

Automatic software system optimization can improve software speed, reduce operating costs, and save energy. Traditional approaches to optimization rely on manual tuning and compiler heuristics, limiting their ability to generalize across…

We present the first loss agent, dubbed LossAgent, for low-level image processing tasks, e.g., image super-resolution and restoration, intending to achieve any customized optimization objectives of low-level image processing in different…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Bingchen Li , Xin Li , Yiting Lu , Zhibo Chen

Numerous challenges in science and engineering can be framed as optimization tasks, including the maximization of reaction yields, the optimization of molecular and materials properties, and the fine-tuning of automated hardware protocols.…

Optimization and Control · Mathematics 2021-11-19 Matteo Aldeghi , Florian Häse , Riley J. Hickman , Isaac Tamblyn , Alán Aspuru-Guzik

Recent advancements in LLM-powered agents have demonstrated significant potential in generating human-like responses; however, they continue to face challenges in maintaining long-term interactions within complex environments, primarily due…

Molecular optimization is a key challenge in drug discovery and material science domain, involving the design of molecules with desired properties. Existing methods focus predominantly on single-property optimization, necessitating…

Machine Learning · Computer Science 2024-09-13 Aye Phyu Phyu Aung , Jay Chaudhary , Ji Wei Yoon , Senthilnath Jayavelu

Evaluating LLMs and text-to-image models is a computationally intensive task often overlooked. Efficient evaluation is crucial for understanding the diverse capabilities of these models and enabling comparisons across a growing number of…

The code written by developers usually suffers from efficiency problems and contain various performance bugs. These inefficiencies necessitate the research of automated refactoring methods for code optimization. Early research in code…

Software Engineering · Computer Science 2024-08-23 Shuzheng Gao , Cuiyun Gao , Wenchao Gu , Michael Lyu

Prompt engineering is crucial for effective interaction with generative artificial intelligence systems, yet existing optimisation methods often operate over an unstructured and vast prompt space, leading to high computational costs and…

Artificial Intelligence · Computer Science 2026-05-15 Devika Prasad , Luke Gerschwitz , Tong Li , Henry Xiao , Anjin Liu , Coco Wu , Anna Leontjeva , Luiz Pizzato

We are interested in in silico evaluation methodology for molecular optimization methods. Given a sample of molecules and their properties of our interest, we wish not only to train an agent that can find molecules optimized with respect to…

Machine Learning · Computer Science 2022-01-31 Hiroshi Kajino , Kohei Miyaguchi , Takayuki Osogami

Recently, Large Language Models (LLMs) have been applied to scientific equation discovery, leveraging their embedded scientific knowledge for hypothesis generation. However, current methods typically confine LLMs to the role of an equation…

Artificial Intelligence · Computer Science 2026-02-18 Shijie Xia , Yuhan Sun , Pengfei Liu

We introduce LEGOMem, a modular procedural memory framework for multi-agent large language model (LLM) systems in workflow automation. LEGOMem decomposes past task trajectories into reusable memory units and flexibly allocates them across…

Artificial Intelligence · Computer Science 2025-10-07 Dongge Han , Camille Couturier , Daniel Madrigal Diaz , Xuchao Zhang , Victor Rühle , Saravan Rajmohan

Drug discovery remains a formidable challenge: more than 90 percent of candidate molecules fail in clinical evaluation, and development costs often exceed one billion dollars per approved therapy. Disparate data streams, from genomics and…

Artificial Intelligence · Computer Science 2025-04-28 Kevin Song , Andrew Trotter , Jake Y. Chen

Generating a novel and optimized molecule with desired chemical properties is an essential part of the drug discovery process. Failure to meet one of the required properties can frequently lead to failure in a clinical test which is costly.…

Machine Learning · Computer Science 2020-10-28 Bonggun Shin , Sungsoo Park , JinYeong Bak , Joyce C. Ho

Robust optimization (RO) provides a principled framework for decision-making under uncertainty, but its practical use is often limited by the need to manually reformulate uncertain optimization models into tractable deterministic…

Artificial Intelligence · Computer Science 2026-05-13 Jinbiao Chen , Shuang Jin , Guoyun Zhang , Junyu Zhang , Guanyi Wang , Hanzhang Qin