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The maximum entropy principle from statistical mechanics states that a closed system attains an equilibrium distribution that maximizes its entropy. We first show that for graphs with fixed number of edges one can define a stochastic edge…

Disordered Systems and Neural Networks · Physics 2007-05-23 Jesse S. A. Bridgewater , P. Oscar Boykin , Vwani P. Roychowdhury

While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learned how to extract this information to predict the three--dimensional, biologically active, native conformation of…

Biomolecules · Quantitative Biology 2009-11-10 R. A. Broglia , G. Tiana

Active matter systems, from self-propelled colloids to motile bacteria, are characterized by the conversion of free energy into useful work at the microscopic scale. They involve physics beyond the reach of equilibrium statistical…

Statistical Mechanics · Physics 2024-06-18 Nicholas M. Boffi , Eric Vanden-Eijnden

Motivation: Peptide-protein interactions (PepPIs) are central to cellular regulation and peptide therapeutics, but experimental characterization remains too slow for large-scale screening. Existing methods usually emphasize either…

Machine Learning · Computer Science 2026-04-28 Chupei Tang , Junxiao Kong , Moyu Tang , Di Wang , Jixiu Zhai , Ronghao Xie , Shangkun Sima , Tianchi Lu

Topographical and diffuse interface reconfigurations occur with a change in the solidification rate. In this article we pursue the hypothesis that the interface configuration during solidification is determined by the rate of entropy…

Materials Science · Physics 2017-02-14 Yaw Delali Bensah , J. A. Sekhar

Entropy is a measure of heterogeneity widely used in applied sciences, often when data are collected over space. Recently, a number of approaches has been proposed to include spatial information in entropy. The aim of entropy is to…

Statistics Theory · Mathematics 2019-11-12 Linda Altieri , Daniela Cocchi , Giulia Roli

We present our angle resolved photoelectron spectroscopy (ARPES) and density functional theory results on quaternary topological insulator (TI) BiSbTe1.25Se1.75 (BSTS) confirming the non-trivial topology of the surface state bands (SSBs) in…

Materials Science · Physics 2023-10-31 H. Lohani , P. Mishra , A. Banerjee , K. Majhi , R. Ganesan , U. Manju , D. Topwal , P. S. Anil Kumar , B. R. Sekhar

Accurate prediction of protein-ligand binding affinity is crucial for rapid and efficient drug development. Recently, the importance of predicting binding affinity has led to increased attention on research that models the three-dimensional…

Machine Learning · Computer Science 2024-07-17 Seungyeon Choi , Sangmin Seo , Sanghyun Park

Native electrospray ionization/ion mobility-mass spectrometry (ESI/IM-MS) allows an accurate determination of low-resolution structural features of proteins. Yet, the presence of proton dynamics, observed already by us for DNA in the gas…

Physical systems behave according to their underlying dynamical equations which, in turn, can be identified from experimental data. Explaining data requires selecting mathematical models that best capture the data regularities. Identifying…

Data Analysis, Statistics and Probability · Physics 2014-03-18 Carlo Cafaro

A key challenge in systems biology is the elucidation of the underlying principles, or fundamental laws, which determine the cellular phenotype. Understanding how these fundamental principles are altered in diseases like cancer is important…

Molecular Networks · Quantitative Biology 2014-08-06 Andrew Teschendorff , Peter Sollich , Reimer Kuehn

The entrapment of bacteria near boundary surfaces is of biological and practical importance, yet the underlying physics is still not well understood. We demonstrate that it is crucial to include a commonly neglected entropic effect arising…

Soft Condensed Matter · Physics 2023-07-28 Premkumar Leishangthem , Xinliang Xu

Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especially in the portions where the interaction takes place, turned…

Protein-protein interactions (PPIs) are governed by surface complementarity and hydrophobic interactions at protein interfaces. However, designing diverse and physically realistic protein structure and surfaces that precisely complement…

Machine Learning · Computer Science 2025-11-24 Guanlue Li , Xufeng Zhao , Fang Wu , Sören Laue

Understanding specific ion adsorption within the inner Helmholtz layer remains central to electrochemistry yet experimentally elusive. Here we directly quantify counterion adsorption and extract the associated thermodynamic parameters…

Optics · Physics 2025-10-23 Yuyang Peng , Feng Gu , Chuanshan Tian

We have performed a systematic investigation of the formation of topologically protected boundary states (TPBS) in topological/normal insulators (TI/NI) heterostructures. Using a recently developed scheme to construct {\it ab-initio}…

Materials Science · Physics 2018-03-26 M. Costa , A. T. Costa , Walter A. Freitas , Tome M. Schmidt , M. Buongiorno Nardelli , A. Fazzio

Sample selection improves the efficiency and effectiveness of machine learning models by providing informative and representative samples. Typically, samples can be modeled as a sample graph, where nodes are samples and edges represent…

Machine Learning · Computer Science 2025-03-04 Tianchi Xie , Jiangning Zhu , Guozu Ma , Minzhi Lin , Wei Chen , Weikai Yang , Shixia Liu

Starting from the concept of entropy defect in thermodynamics, we construct the entropy formulation of space plasmas, and then use it to develop a measure of their stationarity. In particular, we show that statistics of this entropy results…

Space Physics · Physics 2025-02-25 George Livadiotis , David J. McComas

The interplay between topology and non-Hermiticity gives rise to exotic dynamic phenomena that challenge conventional wave-packet propagation and entanglement dynamics. While recent studies have established the non-Hermitian skin effect…

Optics · Physics 2026-01-01 Li-Wei Wang , Bolun Hu , Haixiao Zhang , Kefan Sun , Ying Cheng , Jian-Hua Jiang

Ultrafast non-equilibrium dynamics offer a route to study the microscopic interactions that govern macroscopic behavior. In particular, photo-induced phase transitions (PIPTs) in solids provide a test case for how forces, and the resulting…

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