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Learning vectorized embeddings is fundamental to many recommender systems for user-item matching. To enable efficient online inference, representation binarization, which embeds latent features into compact binary sequences, has recently…

Information Retrieval · Computer Science 2025-06-04 Yankai Chen , Yue Que , Xinni Zhang , Chen Ma , Irwin King

In this work, we introduce CellxPert, a scalable multimodal foundation model that unifies single-cell and spatial multi-omics within a common representation space. CellxPert jointly encodes transcriptomic (scRNA-seq),…

Genomics · Quantitative Biology 2026-05-05 Andac Demir , Erik W. Anderson , Jeremy L. Jenkins , Srayanta Mukherjee

The rapid advancement of single-cell ATAC sequencing (scATAC-seq) technologies holds great promise for investigating the heterogeneity of epigenetic landscapes at the cellular level. The amplification process in scATAC-seq experiments often…

Genomics · Quantitative Biology 2024-08-28 Lei Huang , Lei Xiong , Na Sun , Zunpeng Liu , Ka-Chun Wong , Manolis Kellis

Adapting Foundation Models (FMs) for downstream tasks through Federated Learning (FL) emerges a promising strategy for protecting data privacy and valuable FMs. Existing methods fine-tune FM by allocating sub-FM to clients in FL, however,…

Machine Learning · Computer Science 2024-04-30 Zhaopeng Peng , Xiaoliang Fan , Yufan Chen , Zheng Wang , Shirui Pan , Chenglu Wen , Ruisheng Zhang , Cheng Wang

Artificial neural network has achieved unprecedented success in the medical domain. This success depends on the availability of massive and representative datasets. However, data collection is often prevented by privacy concerns and people…

Machine Learning · Computer Science 2019-11-18 Rulin Shao , Hongyu He , Hui Liu , Dianbo Liu

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Large-batch SGD is important for scaling training of deep neural networks. However, without fine-tuning hyperparameter schedules, the generalization of the model may be hampered. We propose to use batch augmentation: replicating instances…

Machine Learning · Computer Science 2019-01-29 Elad Hoffer , Tal Ben-Nun , Itay Hubara , Niv Giladi , Torsten Hoefler , Daniel Soudry

Models pre-trained on large-scale datasets are often fine-tuned to support newer tasks and datasets that arrive over time. This process necessitates storing copies of the model over time for each task that the pre-trained model is…

Computer Vision and Pattern Recognition · Computer Science 2023-09-22 Chaitanya Devaguptapu , Samarth Sinha , K J Joseph , Vineeth N Balasubramanian , Animesh Garg

Federated learning (FL) enables collaborative model training across distributed clients while preserving data privacy. However, data and system heterogeneity often cause catastrophic forgetting and unbounded drift in model updates, leading…

Machine Learning · Computer Science 2026-04-28 Taehwan Yoon , Bongjun Choi , Wesley De Neve

Continual learning (CL) seeks to mitigate catastrophic forgetting when models are trained with sequential tasks. A common approach, experience replay (ER), stores past exemplars but only sparsely approximates the data distribution, yielding…

Machine Learning · Computer Science 2025-11-11 Chih-Fan Hsu , Ming-Ching Chang , Wei-Chao Chen

This paper introduces the Single-Cell Perturbation Prediction Diffusion Model (scPPDM), the first diffusion-based framework for single-cell drug-response prediction from scRNA-seq data. scPPDM couples two condition channels,…

Quantitative Methods · Quantitative Biology 2025-10-15 Zhaokang Liang , Shuyang Zhuang , Xiaoran Jiao , Weian Mao , Hao Chen , Chunhua Shen

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

Existing LLMs-post-training techniques are broadly categorized into supervised fine-tuning (SFT) and reinforcement fine-tuning (RFT). Each paradigm presents a distinct trade-off: (1) SFT excels at mimicking demonstration data, but can lead…

Machine Learning · Computer Science 2026-05-18 Zeyu Huang , Tianhao Cheng , Zihan Qiu , Zili Wang , Yinghui Xu , Edoardo M. Ponti , Ivan Titov

Dataset distillation is a newly emerging task that synthesizes a small-size dataset used in training deep neural networks (DNNs) for reducing data storage and model training costs. The synthetic datasets are expected to capture the essence…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Jiawei Du , Qin Shi , Joey Tianyi Zhou

This paper studies power-efficient uplink transmission design for federated learning (FL) that employs over-the-air analog aggregation and multi-antenna beamforming at the server. We jointly optimize device transmit weights and receive…

Information Theory · Computer Science 2025-01-31 Faeze Moradi Kalarde , Min Dong , Ben Liang , Yahia A. Eldemerdash Ahmed , Ho Ting Cheng

Single-cell RNA sequencing (scRNA-seq) technology has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. However, the high-dimensional sparsity, batch effect noise, category…

Machine Learning · Computer Science 2025-03-07 Zhen Yu , Jianan Han , Yang Liu , Qingchao Chen

Model fine-tuning is a widely used transfer learning approach in person Re-identification (ReID) applications, which fine-tuning a pre-trained feature extraction model into the target scenario instead of training a model from scratch. It is…

Computer Vision and Pattern Recognition · Computer Science 2020-11-09 Zhengxu Yu , Dong Shen , Zhongming Jin , Jianqiang Huang , Deng Cai , Xian-Sheng Hua

In cloud ML inference systems, batching is an essential technique to increase throughput which helps optimize total-cost-of-ownership. Prior graph batching combines the individual DNN graphs into a single one, allowing multiple inputs to be…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-10-27 Yujeong Choi , Yunseong Kim , Minsoo Rhu

As the ever-increasing token limits of large language models (LLMs) have enabled long context as input, prompting with single data samples might no longer an efficient way. A straightforward strategy improving efficiency is to batch data…

Computation and Language · Computer Science 2024-07-16 Jianzhe Lin , Maurice Diesendruck , Liang Du , Robin Abraham

Self-supervised methods in vision have been mostly focused on large architectures as they seem to suffer from a significant performance drop for smaller architectures. In this paper, we propose a simple self-supervised distillation…

Computer Vision and Pattern Recognition · Computer Science 2023-01-24 Quentin Duval , Ishan Misra , Nicolas Ballas