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Electron microscopes have been improved to achieve ever smaller beam spots, a key parameter that determines the instrument's resolution. The techniques to measure the size of the beam, however, have not progressed to the same degree. There…
Monitoring the activity of the heart is important for diagnosing and preventing cardiovascular diseases. The electrocardiogram (ECG) is the gold standard for diagnosing such diseases. It monitors the heart's electrical activity, and while…
The aim of this paper is to give an introductory review of the cryoelectron microscopy as a complex data source for the most of the system biology branches, including the most perspective non-local approaches known as "localomics" and…
The Electrocardiograph signal represents the heart's electrical activity while blood pressure results from the heart's mechanical activity. Previous studies have investigated how the heart's electrical and mechanical activities are related…
Aberration-corrected scanning transmission electron microscopes (STEM) provide sub-angstrom lateral resolution; however, the large convergence angle greatly reduces the depth of field. For microscopes with a small depth of field,…
Electron and x-ray microscopes allow one to image the entire, unlabeled structure of hydrated materials at a resolution well beyond what visible light microscopes can achieve. However, both approaches involve ionizing radiation, so that…
The physical and chemical environment inside cells is of fundamental importance to all life but has traditionally been difficult to determine on a subcellular basis. Here we combine cutting-edge genomically integrated FRET biosensing to…
In photoelectron circular dichroism (PECD) it is generally difficult to trace how and when the chirality of the molecule is imprinted onto the photoelectron. We present simulations of PECD in a simple model and employ chirality measures to…
We demonstrate the merits of using a neuromorphic, or event-based camera (EBC), for tracking of both passive and active matter. For passive matter, we tracked the Brownian motion of different micro-particles and estimated their diffusion…
Electron energy loss spectroscopy is consolidating as a powerful tool to explore electronic (as well as vibrational) excitations of matter, including molecules. Performed in a scanning transmission electron microscope, this technique is…
Electrochemiluminescence (ECL) produces light through electrochemical reactions and has shown promise for various analytic applications in biomedicine. However, the use of ECL devices (ECLDs) as light sources has been limited due to…
Single molecules that exhibit narrow optical transitions at cryogenic temperatures can be used as local electric-field sensors. We derive the single charge sensitivity of aromatic organic dye molecules, based on first principles. Through…
Bacteria sense a diverse range of environmental analytes with high sensitivity and temporal resolution. Engineering and synthetic biology approaches enabled harnessing this capability through development of whole-cell biosensors that…
Simultaneous electrocardiography (ECG) and phonocardiogram (PCG) provide a comprehensive, multimodal perspective on cardiac function by capturing the heart's electrical and mechanical activities, respectively. However, the distinct and…
Low-light optical imaging refers to the use of cameras to capture images with minimal photon flux. This area has broad application to diverse fields, including optical microscopy for biological studies. In such studies, it is important to…
We describe the characteristics of low-cost ultra-high-power light emitting diodes (LEDs) for use in optical imaging experiments. We use the LEDs in experiments with bullfrog cardiac tissue and find that the signal-to-noise ratio is…
Over the last decade, single-molecule optical microscopy has become the gold-standard approach to decipher complex molecular processes in cellular environments. [1-3] Single-molecule fluorescence microscopy has several advantages such as…
Space-based stellar coronagraph instruments aim to directly image exoplanets that are a fraction of an arcsecond separation and ten billion times fainter than their host star. To achieve this, one or more deformable mirrors (DMs) are used…
Echocardiography (echo), or cardiac ultrasound, is the most widely used imaging modality for cardiac form and function due to its relatively low cost, rapid acquisition time, and non-invasive nature. However, ultrasound acquisitions are…
In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is…