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Combinatorial optimization is essential across numerous disciplines. Traditional metaheuristics excel at exploring complex solution spaces efficiently, yet they often struggle with scalability. Deep learning has become a viable alternative…

Emerging Technologies · Computer Science 2025-04-09 Aitor Morais , Eneko Osaba , Iker Pastor , Izaskun Oregui

Major obstacles remain to the implementation of macroscopic quantum computing: hardware problems of noise, decoherence, and scaling; software problems of error correction; and, most important, algorithm construction. Finding truly quantum…

Quantum Physics · Physics 2020-07-17 Nathan Thompson , James Steck , Elizabeth Behrman

Along with the development of quantum technology, finding useful applications of quantum computers has been a central pursuit. Despite various quantum algorithms have been developed, many of them often require strong input assumptions,…

Quantum Physics · Physics 2026-02-25 Nhat A. Nghiem

Quantum computing has evolved quickly in recent years and is showing significant benefits in a variety of fields, especially in the realm of cybersecurity. The combination of software used to locate the most frequent hashes and $n$-grams…

Quantum Physics · Physics 2022-05-09 Nicholas R. Allgood , Charles K. Nicholas

As quantum computing technology advances, the complexity of quantum algorithms increases, necessitating a shift from low-level circuit descriptions to high-level programming paradigms. This paper addresses the challenges of developing a…

Quantum Physics · Physics 2025-03-04 Israel Reichental , Ravid Alon , Lior Preminger , Matan Vax , Amir Naveh

There is no unique way to encode a quantum algorithm into a quantum circuit. With limited qubit counts, connectivities, and coherence times, circuit optimization is essential to make the best use of near-term quantum devices. We introduce…

De novo DNA assembly is a fundamental task in Bioinformatics, and finding Eulerian paths on de Bruijn graphs is one of the dominant approaches to it. In most of the cases, there may be no one order for the de Bruijn graph that works well…

Data Structures and Algorithms · Computer Science 2018-05-15 Diego Díaz-Domínguez , Djamal Belazzougui , Travis Gagie , Veli Mäkinen , Gonzalo Navarro , Simon J. Puglisi

Deep sequencing has enabled the investigation of a wide range of environmental microbial ecosystems, but the high memory requirements for {\em de novo} assembly of short-read shotgun sequencing data from these complex populations are an…

Genomics · Quantitative Biology 2015-06-03 Jason Pell , Arend Hintze , Rosangela Canino-Koning , Adina Howe , James M. Tiedje , C. Titus Brown

Hyperparameter tuning is a critical yet computationally expensive step in training neural networks, particularly when the search space is high dimensional and nonconvex. Metaheuristic optimization algorithms are often used for this purpose…

Neural and Evolutionary Computing · Computer Science 2026-01-22 Amaras Nazarians , Sachin Kumar

Optical molecular tomographic imaging is to reconstruct the concentration distribution of photon-molecular probes in a small animal from measured photon fluence rates. The localization and quantification of molecular probes is related to…

Biological Physics · Physics 2017-07-18 Wenxiang Cong , Xavier Intes , Ge Wang

The recent emergence of novel computational devices, such as quantum computers, coherent Ising machines, and digital annealers presents new opportunities for hardware-accelerated hybrid optimization algorithms. Unfortunately, demonstrations…

Optimization and Control · Mathematics 2020-10-21 Yuchen Pang , Carleton Coffrin , Andrey Y. Lokhov , Marc Vuffray

High-throughput sequencing (HTS) is revolutionizing biological research by enabling scientists to quickly and cheaply query variation at a genomic scale. Despite the increasing ease of obtaining such data, using these data effectively still…

Genomics · Quantitative Biology 2012-11-09 Sonal Singhal

Quantum search algorithms are considered in the context of protein sequence comparison in biocomputing. Given a sample protein sequence of length m (i.e m residues), the problem considered is to find an optimal match in a large database…

Quantum Physics · Physics 2009-11-06 Lloyd C. L. Hollenberg

This paper presents key enhancements to our previous work~\cite{naghmouchi2024mixed} on a hybrid Benders decomposition (HBD) framework for solving mixed integer linear programs (MILPs). In our approach, the master problem is reformulated as…

Quantum Physics · Physics 2026-01-23 Anna Joliot , M. Yassine Naghmouchi , Wesley Coelho

This paper proposes Genetic Algorithm with Border Trades (GAB), a novel modification of the standard genetic algorithm that enhances exploration by incorporating new chromosome patterns in the breeding process. This approach significantly…

Machine Learning · Computer Science 2025-06-27 Qingchuan Lyu

A new approach to efficient quantum computation with probabilistic gates is proposed and analyzed in both a local and non-local setting. It combines heralded gates previously studied for atom or atom-like qubits with logical encoding from…

Quantum Physics · Physics 2017-04-19 Johannes Borregaard , Anders S. Sørensen , Ignacio Cirac , Mikhail D. Lukin

Machine learning techniques have led to broad adoption of a statistical model of computing. The statistical distributions natively available on quantum processors are a superset of those available classically. Harnessing this attribute has…

Quantum annealing (QA) has emerged as a powerful technique to solve optimization problems by taking advantages of quantum physics. In QA process, a bottleneck that may prevent QA to scale up is minor embedding step in which we embed…

Quantum Physics · Physics 2023-07-06 Hoang M. Ngo , Tamer Kahveci , My T. Thai

Efficient entanglement distribution is the foundational challenge in realizing large-scale Quantum Networks. However, state-of-the-art solutions are frequently limited by restrictive operational assumptions, prohibitive computational…

The thesis deals with Quantum Algorithms for solving Hard Constrained Optimization Problems. It shows how quantum computers can solve difficult everyday problems such as finding the best schedule for social workers or the path of a robot…

Quantum Physics · Physics 2022-03-01 Parfait Atchade-Adelomou