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Large language models (LLMs) have a transformative impact on a variety of scientific tasks across disciplines including biology, chemistry, medicine, and physics. However, ensuring the safety alignment of these models in scientific research…

Safety alignment for large language models (LLMs) aims to reduce harmful or unsafe behavior while preserving general utility. However, recent findings reveal that alignment effects can be fragile: lightweight post-alignment manipulations,…

Artificial Intelligence · Computer Science 2026-05-29 Zhihao Liu , Yifan Wu , Jian Lou , Di Wang , Yuxi Zhou , Yuke Hu

Large Language Models (LLMs) exhibit impressive capabilities but also present risks such as biased content generation and privacy issues. One of the current alignment techniques includes principle-driven integration, but it faces challenges…

Computation and Language · Computer Science 2025-05-30 Yi Luo , Zhenghao Lin , Yuhao Zhang , Jiashuo Sun , Chen Lin , Chengjin Xu , Xiangdong Su , Yelong Shen , Jian Guo , Yeyun Gong

As large language models (LLMs) are overwhelmingly more and more integrated into various applications, ensuring they generate safe responses is a pressing need. Previous studies on alignment have largely focused on general…

Computation and Language · Computer Science 2026-03-16 Jianwei Li , Jung-Eun Kim

Large language models (LLMs) often require fine-tuning (FT) to perform well on downstream tasks, but FT can induce safety-alignment drift even when the training dataset contains only benign data. Prior work shows that introducing a small…

Computation and Language · Computer Science 2026-03-10 Guoli Wang , Haonan Shi , Tu Ouyang , An Wang

Safety alignment of large language models remains brittle under domain shift and noisy preference supervision. Most existing robust alignment methods focus on uncertainty in alignment data, while overlooking optimization-induced fragility…

Machine Learning · Computer Science 2026-05-22 Yonghui Yang , Wenjian Tao , Jilong Liu , Xingyu Zhu , Junfeng Fang , Weibiao Huang , Le Wu , Richang Hong , Tat-Sent Chua

The safety alignment ability of Vision-Language Models (VLMs) is prone to be degraded by the integration of the vision module compared to its LLM backbone. We investigate this phenomenon, dubbed as ''safety alignment degradation'' in this…

Computation and Language · Computer Science 2024-10-14 Qin Liu , Chao Shang , Ling Liu , Nikolaos Pappas , Jie Ma , Neha Anna John , Srikanth Doss , Lluis Marquez , Miguel Ballesteros , Yassine Benajiba

Large language models (LLMs) have achieved remarkable success across many applications, but their ability to generate harmful content raises serious safety concerns. Although safety alignment techniques are often applied during pre-training…

Machine Learning · Computer Science 2026-04-24 Chengcan Wu , Zhixin Zhang , Zeming Wei , Yihao Zhang , Xiaokun Luan , Meng Sun

Large language models (LLMs) and multimodal LLMs are typically safety-aligned before release to prevent harmful content generation. However, recent studies show that safety behaviors are concentrated in a small subset of parameters, making…

Machine Learning · Computer Science 2026-02-13 Zhaoxin Wang , Jiaming Liang , Fengbin Zhu , Weixiang Zhao , Junfeng Fang , Jiayi Ji , Handing Wang , Tat-Seng Chua

Recent advancements in Large Language Models (LLMs) have sparked widespread concerns about their safety. Recent work demonstrates that safety alignment of LLMs can be easily removed by fine-tuning with a few adversarially chosen…

Computation and Language · Computer Science 2025-03-03 Samuele Poppi , Zheng-Xin Yong , Yifei He , Bobbie Chern , Han Zhao , Aobo Yang , Jianfeng Chi

Merging large language models (LLMs) is a practical way to compose capabilities from multiple fine-tuned checkpoints without retraining. Yet standard schemes (linear weight soups, task vectors, and Fisher-weighted averaging) can preserve…

Artificial Intelligence · Computer Science 2025-12-19 Aniruddha Roy , Jyoti Patel , Aman Chadha , Vinija Jain , Amitava Das

Multimodal Large Language Models (MLLMs) pose critical safety challenges, as they are susceptible not only to adversarial attacks such as jailbreaking but also to inadvertently generating harmful content for benign users. While internal…

Machine Learning · Computer Science 2026-03-17 Ming Wen , Kun Yang , Xin Chen , Jingyu Zhang , Dingding Han , Shiwen Cui , Yuedong Xu

With rapid advancement and increasing accessibility of LLMs, fine-tuning aligned models has become a critical step for adapting them to real-world applications, which makes the safety of this fine-tuning process more important than ever.…

Cryptography and Security · Computer Science 2025-07-28 Hao Li , Lijun Li , Zhenghao Lu , Xianyi Wei , Rui Li , Jing Shao , Lei Sha

Low-rank and sparse composite approximation is a natural idea to compress Large Language Models (LLMs). However, such an idea faces two primary challenges that adversely affect the performance of existing methods. The first challenge…

Machine Learning · Computer Science 2026-02-27 Changhai Zhou , Qian Qiao , Yuhua Zhou , Yuxin Wu , Shichao Weng , Weizhong Zhang , Cheng Jin

While fine-tuning services drive the rapid expansion of task capabilities in large language models (LLMs), they are often accompanied by the degradation and reorganization of safety-aligned representations, making models more prone to…

Machine Learning · Computer Science 2026-02-02 Bing Han , Feifei Zhao , Dongcheng Zhao , Guobin Shen , Ping Wu , Yu Shi , Yi Zeng

The application scope of Large Language Models (LLMs) continues to expand, leading to increasing interest in personalized LLMs that align with human values. However, aligning these models with individual values raises significant safety…

Computation and Language · Computer Science 2025-06-10 Sooyung Choi , Jaehyeok Lee , Xiaoyuan Yi , Jing Yao , Xing Xie , JinYeong Bak

This paper presents a comprehensive empirical study on the safety alignment capabilities. We evaluate what matters for safety alignment in LLMs and LRMs to provide essential insights for developing more secure and reliable AI systems. We…

Computation and Language · Computer Science 2026-02-25 Xing Li , Hui-Ling Zhen , Lihao Yin , Xianzhi Yu , Zhenhua Dong , Mingxuan Yuan

Large language models (LLMs) are increasingly prevalent across diverse applications. However, their enormous size limits storage and processing capabilities to a few well-resourced stakeholders. As a result, most applications rely on…

Computation and Language · Computer Science 2025-11-05 Mohammadsajad Alipour , Mohammad Mohammadi Amiri

The emergence of autonomous Large Language Model (LLM) agents capable of tool usage has introduced new safety risks that go beyond traditional conversational misuse. These agents, empowered to execute external functions, are vulnerable to…

Artificial Intelligence · Computer Science 2025-07-14 Zeyang Sha , Hanling Tian , Zhuoer Xu , Shiwen Cui , Changhua Meng , Weiqiang Wang

Large Language Models (LLMs) with safe-alignment training are powerful instruments with robust language comprehension capabilities. These models typically undergo meticulous alignment procedures involving human feedback to ensure the…

Machine Learning · Computer Science 2025-09-22 Maithili Joshi , Palash Nandi , Tanmoy Chakraborty